ChemicalBook > CAS DataBase List > MONO-BENZYL MALONATE

MONO-BENZYL MALONATE

Product Name
MONO-BENZYL MALONATE
CAS No.
40204-26-0
Chemical Name
MONO-BENZYL MALONATE
Synonyms
MONO-BENZYL MALONATE;Mono-Benzyl Malonate 95%;Mono-benzyl malonate, 95%,;MALONIC ACID MONO-BENZYL ESTER;3-oxo-3-phenylmethoxypropanoate;3-(benzyloxy)-3-oxopropanoic acid;3-oxo-3-phenylmethoxypropanoic acid;Propanedioic acid, 1-(phenylmethyl) ester;Propanedioic acid, Mono(phenylMethyl) ester
CBNumber
CB1273234
Molecular Formula
C10H10O4
Formula Weight
194.18
MOL File
40204-26-0.mol
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MONO-BENZYL MALONATE Property

Melting point:
47-51 °C (lit.)
Boiling point:
352.3±25.0 °C(Predicted)
Density 
1.0737 g/cm3
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
2.82±0.32(Predicted)
form 
Powder or Crystalline Powder
color 
White to off-white
InChIKey
CFLAHQSWDKNWPW-UHFFFAOYSA-N
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Safety

WGK Germany 
3
HS Code 
2917399590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
460656
Product name
mono-Benzyl malonate
Purity
95%
Packaging
10g
Price
$20.8
Updated
2025/07/31
TRC
Product number
M524880
Product name
mono-Benzyl malonate
Packaging
50g
Price
$575
Updated
2021/12/16
Usbiological
Product number
456515
Product name
Monobenzyl Malonate
Packaging
1g
Price
$319
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CRB0002079
Product name
MONO-BENZYL MALONATE
Purity
95.00%
Packaging
1G
Price
$637.3
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
60426
Product name
mono-Benzyl malonate
Packaging
10g
Price
$875
Updated
2021/12/16
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MONO-BENZYL MALONATE Chemical Properties,Usage,Production

Uses

Monobenzyl Malonate is a useful synthetic intermediate. It was used to synthesize constrained cyclic agonists of the cholecystokinin CCK-B receptor. It was also used to prepare aspartate transcarbamoylase inhibitors.

Definition

ChEBI: A dicarboxylic acid monoester obtained by the formal condensation of one of the carboxy groups of malonic acid with benzyl alcohol.

General Description

mono-Benzyl malonate can be synthesized by the reaction of Meldrum′s acid (2,2-dimethyl- 1,3-dioxane-4,6-dione) with benzyl alcohol.

Synthesis

2033-24-1

100-51-6

40204-26-0

Meldrum acid (2.00 g, 13.8 mmol) and anhydrous acetonitrile (40 mL) were added to a flame-dried 150 mL pressure tube under argon protection. Benzyl alcohol (1.44 mL, 13.8 mmol) was added to the resulting solution and the reaction tube was sealed. The reaction mixture was refluxed overnight. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure and the product was purified by column chromatography (eluent: 70/30 hexane/ethyl acetate) to afford the target product, monophenylmethyl malonate (1.28 g, 6.59 mmol), as a colorless oil in 48% yield.

References

[1] Helvetica Chimica Acta, 2002, vol. 85, # 1, p. 288 - 319
[2] Heterocycles, 1993, vol. 35, # 2, p. 1205 - 1235
[3] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 3, p. 1143 - 1148
[4] Journal of Organometallic Chemistry, 2001, vol. 619, # 1-2, p. 179 - 193
[5] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 21, p. 4933 - 4936

MONO-BENZYL MALONATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from MONO-BENZYL MALONATE manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
mono-benzyl malonate 40204-26-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-28
Career Henan Chemical Co
Product
MONO-BENZYL MALONATE 40204-26-0
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200kg
Release date
2018-12-24

40204-26-0, MONO-BENZYL MALONATERelated Search:

BENZYL TERT-BUTYL MALONATE BENZYL ETHYL MALONATE PHENYLMALONIC ACID MONOBENZYL ESTER MONO-BENZYL MALONATE MALONIC ACID MONO-4-NITROBENZYL ESTER MAGNESIUM SALT Anhydrous Magnesium Mono-Benzyl Malonate 4-Nitrobenzyl hydrogen malonate BENZYL METHYL MALONATE DIBENZYL MALONATE Malonic acid MALONIC ACID BIS(4-NITROBENZYL) ESTER MONO-BENZYL MALONATE FMOC-DL-GLA(OBZL)2-OH BOC-DL-GLA(OBZL)2-OH 5-METHYL-2-OXO-5-PHENYL-2,5-DIHYDROFURAN-3-CARBOXYLIC ACID METHYL ESTER BOC-L-GLA(OBZL)2-OH FMOC-L-GLA(OBZL)2-OH 2,5-DIHYDRO-2-OXO-5-PHENYL-5-(2-PROPENYL)-3-FURANCARBOXYLIC ACID, METHYL ESTER

  • MONO-BENZYL MALONATE
  • MALONIC ACID MONO-BENZYL ESTER
  • Propanedioic acid, Mono(phenylMethyl) ester
  • Mono-Benzyl Malonate 95%
  • 3-(benzyloxy)-3-oxopropanoic acid
  • 3-oxo-3-phenylmethoxypropanoate
  • Propanedioic acid, 1-(phenylmethyl) ester
  • 3-oxo-3-phenylmethoxypropanoic acid
  • Mono-benzyl malonate, 95%,
  • 40204-26-0
  • C6H5CH2O2CCH2CO2H
  • Organic Building Blocks
  • Esters
  • Building Blocks
  • Carbonyl Compounds
  • C10 to C11
  • C10 to C11
  • Carbonyl Compounds
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