ChemicalBook > CAS DataBase List > 2-(HYDROXYMETHYL)BENZO[B]THIOPHENE

2-(HYDROXYMETHYL)BENZO[B]THIOPHENE

Product Name
2-(HYDROXYMETHYL)BENZO[B]THIOPHENE
CAS No.
17890-56-1
Chemical Name
2-(HYDROXYMETHYL)BENZO[B]THIOPHENE
Synonyms
BUTTPARK 36\18-21;RARECHEM AL BD 0483;BENZOTHIOPHENE-2-METHANOL;1-Benzothien-2-ylmethanol;1-BENZOTHIOPHEN-2-YLMETHANOL;Benzo[b]thiophene-2-methanol;1-BENZOTHIOPHENE-2-YLMETHANOL;Benzo[b]thiophen-2-ylmethanol;2-(HYDROXYMETHYL)BENZOTHIOPHENE;Benzo[b]thiophene-2-methanol,97%
CBNumber
CB1274392
Molecular Formula
C9H8OS
Formula Weight
164.22
MOL File
17890-56-1.mol
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2-(HYDROXYMETHYL)BENZO[B]THIOPHENE Property

Melting point:
98-101°C
Boiling point:
108-110 °C(Press: 4 Torr)
Density 
1.294±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
13.89±0.10(Predicted)
color 
White to Orange to Green
CAS DataBase Reference
17890-56-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
679542
Product name
Benzothiophene-2-methanol
Purity
97%
Packaging
1g
Price
$80
Updated
2023/01/07
TCI Chemical
Product number
B4628
Product name
Benzo[b]thiophene-2-methanol
Purity
>98.0%(GC)
Packaging
1g
Price
$57
Updated
2025/07/31
TCI Chemical
Product number
B4628
Product name
Benzo[b]thiophene-2-methanol
Purity
>98.0%(GC)
Packaging
5g
Price
$192
Updated
2025/07/31
TRC
Product number
H999793
Product name
2-(Hydroxymethyl)benzo[b]thiophene
Packaging
100mg
Price
$75
Updated
2021/12/16
TRC
Product number
H999793
Product name
2-(Hydroxymethyl)benzo[b]thiophene
Packaging
50mg
Price
$60
Updated
2021/12/16
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2-(HYDROXYMETHYL)BENZO[B]THIOPHENE Chemical Properties,Usage,Production

Chemical Properties

White to yellow solid

Uses

Benzo[b]thiophene-2-methano is an important intermediates and reagents in organic synthesis.

Synthesis

17890-55-0

17890-56-1

The general procedure for the synthesis of 1-benzothiophene-2-methanol using ethyl benzo[b]thiophene-2-carboxylate as a starting material was as follows: lithium aluminum hydride (712 mg) was suspended in dry tetrahydrofuran (15 mL) and cooled to 0°C in an ice bath. At this temperature, a solution of ethyl benzo[b]thiophene-2-carboxylate (2.06 g, 10 mmol) in tetrahydrofuran (15 mL) was slowly added dropwise. After the dropwise addition was completed, the reaction was kept at 0°C and stirring was continued for 1 hour. Subsequently, the reaction was quenched by careful addition of 1N hydrochloric acid (150 mL) and stirring was continued for 15 minutes. The reaction mixture was extracted with ethyl acetate, the organic layers were combined and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give the white crystalline product 1-benzothiophene-2-methanol (1.51 g, 92% yield). The product was characterized by 1H-NMR (CDCl3, 270 MHz) with chemical shifts of δ= 7.86-7.67 (m, 2H), 7.42-7.20 (m, 3H), 4.91 (s, 2H), 2.02 (bs, 1H).

References

[1] Patent: US2003/109570, 2003, A1
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 3, p. 457 - 465
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 8, p. 2922 - 2926
[4] Organic Letters, 2016, vol. 18, # 8, p. 1828 - 1831
[5] Synlett, 2017, vol. 28, # 1, p. 133 - 137

2-(HYDROXYMETHYL)BENZO[B]THIOPHENE Preparation Products And Raw materials

Raw materials

Thianaphthene N,N-Dimethylformamide Tetrahydrofuran Lithium Aluminum Hydride n-Butyllithium

Preparation Products

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2-(HYDROXYMETHYL)BENZO[B]THIOPHENE Suppliers

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View Lastest Price from 2-(HYDROXYMETHYL)BENZO[B]THIOPHENE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-(HYDROXYMETHYL)BENZO[B]THIOPHENE 17890-56-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2024-12-03
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-(HYDROXYMETHYL)BENZO[B]THIOPHENE 17890-56-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
2-(HYDROXYMETHYL)BENZO[B]THIOPHENE 17890-56-1
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-10

17890-56-1, 2-(HYDROXYMETHYL)BENZO[B]THIOPHENERelated Search:

Thianaphthene-2-carboxylic acid METHYL BENZO[B]THIOPHENE-2-CARBOXYLATE 3-CHLOROBENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL 3-CHLOROBENZO[B]THIOPHENE-2-CARBOXYLATE 5-METHYLBENZO[B]THIOPHENE-2-METHANOL Thianaphthene METHYL 3-HYDROXYBENZO[B]THIOPHENE-2-CARBOXYLATE 3-BROMOBENZOTHIOPHENE-2-CARBOXYLIC ACID& ETHYL BENZO[B]THIOPHENE-2-CARBOXYLATE 3-CHLORO-6-NITRO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL 6-CHLORO-3-HYDROXYBENZO[B]THIOPHENE-2-CARBOXYLATE 3,7-DICHLORO-6-METHOXY-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID 3-CHLORO-6-FLUOROBENZO(B)THIOPHENE-2-CA& METHYL 3-AMINOBENZO[B]THIOPHENE-2-CARBOXYLATE METHYL 3-AMINO-5-NITROBENZO[B]THIOPHENE-2-CARBOXYLATE 3-Chloro-6-methoxybenzo[b]thiophene-2-carboxylicacid METHYL 3-CHLORO-6-FLUOROBENZO(B)THIOPHE& 7-(Hydroxymethyl)benzo[b]thiophene,7-(Hydroxymethyl)benzo[b]thiophene 97%

  • 1-Benzothiophen-2-ylmethanol ,98%
  • 2-(HYDROXYMETHYL)BENZO[B]THIOPHENE(BTP-OH)
  • 1-Benzothien-2-ylmethanol
  • Benzo[b]thiophene-2-methanol,97%
  • RARECHEM AL BD 0483
  • 1-BENZOTHIOPHEN-2-YLMETHANOL
  • 1-BENZOTHIOPHENE-2-YLMETHANOL
  • 2-(HYDROXYMETHYL)BENZO[B]THIOPHENE
  • 2-(HYDROXYMETHYL)BENZOTHIOPHENE
  • BUTTPARK 36\18-21
  • BENZOTHIOPHENE-2-METHANOL
  • Benzo[b]thiophene-2-methanol, 98%
  • 2-(Hydroxymethyl)benzo[b]thiophene, Benzo[b]thiophen-2-yl-methanol
  • Benzo[b]thiophen-2-ylmethanol
  • Benzo[b]thiophene-2-methanol &gt
  • 2-(HYDROXYMETHYL)BENZO[B]THIOPHENE ISO 9001：2015 REACH
  • Benzo[b]thiophene-2-methanol
  • 17890-56-1
  • C9H8OS
  • Building Blocks
  • Benzothiophenes
  • Heterocyclic Building Blocks