ChemicalBook > CAS DataBase List > N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride

N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride

Product Name
N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride
CAS No.
189061-11-8
Chemical Name
N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride
Synonyms
N-(4-(4-(2,3-DICHLOROPHENYL)PIPERAZIN-1-YL)BUTYL)-9H-FLUORENE-2-CARBOXAMIDE HCL;9H-Fluorene-2-carboxamide,N-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyl]-, monohydrochloride
CBNumber
CB12750474
Molecular Formula
C28H30Cl3N3O
Formula Weight
530.9163
MOL File
189061-11-8.mol
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N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride Property

storage temp. 
2-8°C
solubility 
DMSO: ≥25mg/mL
form 
powder
color 
white to tan
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0066
Product name
NGB 2904 hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$133
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0066
Product name
NGB 2904 hydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$514
Updated
2025/07/31
Cayman Chemical
Product number
21457
Product name
NGB 2904 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$39
Updated
2024/03/01
Cayman Chemical
Product number
21457
Product name
NGB 2904 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
21457
Product name
NGB 2904 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$210
Updated
2024/03/01
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N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride Chemical Properties,Usage,Production

Uses

NGB 2904 Hydrochloride is a dopamine D3 receptor antagonist that inhibits cocaine’s rewarding effects and cocaine-induced reinstatement of drug seeking behavior in rats.

Biological Activity

Inhibition of dopamine D3 receptor function by NGB 2904 increases spontaneous locomotor activity in rodents.', 'NGB 2904 is a potent and selective dopamine D3 receptor antagonist with a D3/D2 ratio of 800 for r at and high binding affinity (1.4 nM) at the hD3 receptor with 150-fold selectivity for primate D3 receptors over primate D2L receptors. It attenuates the rewarding effects of cocaine and methamphetamine.

in vivo

NGB 2904 (26 μg/kg; a single s.c.) enhances amphetamine (26 mg/kg)-stimulated locomotion in wild-type mice[3].
NGB 2904 (0.026 μg-1 mg/kg; a single s.c. or once daily for 7 d) stimulates spontaneous locomotion in wild-type mice[3].

IC 50

D3 Receptor: 1.4 (Ki)

storage

Desiccate at +4°C

N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride Suppliers

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189061-11-8, N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochlorideRelated Search:


  • N-(4-(4-(2,3-DICHLOROPHENYL)PIPERAZIN-1-YL)BUTYL)-9H-FLUORENE-2-CARBOXAMIDE HCL
  • 9H-Fluorene-2-carboxamide,N-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyl]-, monohydrochloride
  • 189061-11-8