ChemicalBook > CAS DataBase List > MLS-0315848 hydrochloride

MLS-0315848 hydrochloride

Product Name
MLS-0315848 hydrochloride
CAS No.
1135318-57-8
Chemical Name
MLS-0315848 hydrochloride
Synonyms
ML095;ML095 HCL;MLS-0315848 hcl;ML095 hydrochloride;MLS-0315848 hydrochloride;CID-25067483 hydrochloride;1-(3,4-dihydroxyphenyl)-2-(2-ethylimidazol-1-yl)ethanone;1-(3,4-Dihydroxyphenyl)-2-(3-ethyl-1H-pyrazol-1-yl)ethanone Hydrochloride;1-(3,4-Dihydroxyphenyl)-2-(2-ethyl-1H-imidazol-1-yl)-Ethanone hydrochloride;CID-25067483,ML-095,ML 095,ML095 hydrochloride,ML095,inhibit,ML 095 hydrochloride,CID25067483,Inhibitor,CID 25067483
CBNumber
CB12750702
Molecular Formula
C13H15ClN2O3
Formula Weight
282.72
MOL File
1135318-57-8.mol
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MLS-0315848 hydrochloride Property

storage temp. 
2-8°C
solubility 
H2O: soluble5mg/mL, clear
form 
powder
color 
white to beige
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Safety

Hazard Codes 
Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-39
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15173
Product name
ML-095 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
15173
Product name
ML-095 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
15173
Product name
ML-095 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
15173
Product name
ML-095 (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$374
Updated
2024/03/01
TRC
Product number
D454515
Product name
1-(3,4-Dihydroxyphenyl)-2-(3-ethyl-1H-pyrazol-1-yl)ethanoneHydrochloride
Packaging
1mg
Price
$50
Updated
2021/12/16
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MLS-0315848 hydrochloride Chemical Properties,Usage,Production

Uses

1-(3,4-Dihydroxyphenyl)-2-(3-ethyl-1H-pyrazol-1-yl)ethanone Hydrochloride is a biochemical inhibitor of placental alkaline phosphatase (PLAP) and is used to elucidate the key biological functions and natural substrates of human PLAP.

Biological Activity

ml-095 (hydrochloride) is a specific plap inhibitor [1].alkaline phosphatases are hydrolase enzymes responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. there are three isozymes of alkaline phosphatases: placental alkaline phosphatase (plap), intestinal alkaline phosphatase (iap), and tissue non-specific alkaline phosphatase (tnap). placental alkaline phosphatase (plap) is highly expressed in primate placental tissue and the biological function is still unknown. however, plap-like enzymes are detected in serum of patients with primary testicular tumors, in particular seminoma and other cancers [1].ml-095 (cid-25067483) is a biochemical inhibitor of plap and will be useful to elucidate the key biological functions and natural substrates of human plap. ml095 is a specific plap inhibitor and inhibited plap, tnap and iap with ic50 values of 2.1, >100 and 53 μm, respectively. ml095 exhibited greater than 25-fold selectivity over tissue non-specific alkaline phosphatase (tnap) and intestinal alkaline phosphatase (iap) [1].

References

[1]. lanier m, cashman j, sergienko e, et al. placental alkaline phosphatase (plap) luminescent hts assay - probe 2.

MLS-0315848 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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MLS-0315848 hydrochloride Suppliers

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