MLS-0315848 hydrochloride
- Product Name
- MLS-0315848 hydrochloride
- CAS No.
- 1135318-57-8
- Chemical Name
- MLS-0315848 hydrochloride
- Synonyms
- ML095;ML095 HCL;MLS-0315848 hcl;ML095 hydrochloride;MLS-0315848 hydrochloride;CID-25067483 hydrochloride;1-(3,4-dihydroxyphenyl)-2-(2-ethylimidazol-1-yl)ethanone;1-(3,4-Dihydroxyphenyl)-2-(3-ethyl-1H-pyrazol-1-yl)ethanone Hydrochloride;1-(3,4-Dihydroxyphenyl)-2-(2-ethyl-1H-imidazol-1-yl)-Ethanone hydrochloride;CID-25067483,ML-095,ML 095,ML095 hydrochloride,ML095,inhibit,ML 095 hydrochloride,CID25067483,Inhibitor,CID 25067483
- CBNumber
- CB12750702
- Molecular Formula
- C13H15ClN2O3
- Formula Weight
- 282.72
- MOL File
- 1135318-57-8.mol
MLS-0315848 hydrochloride Property
- storage temp.
- 2-8°C
- solubility
- H2O: soluble5mg/mL, clear
- form
- powder
- color
- white to beige
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 15173
- Product name
- ML-095 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 15173
- Product name
- ML-095 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- 15173
- Product name
- ML-095 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 15173
- Product name
- ML-095 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $374
- Updated
- 2024/03/01
- Product number
- D454515
- Product name
- 1-(3,4-Dihydroxyphenyl)-2-(3-ethyl-1H-pyrazol-1-yl)ethanoneHydrochloride
- Packaging
- 1mg
- Price
- $50
- Updated
- 2021/12/16
MLS-0315848 hydrochloride Chemical Properties,Usage,Production
Uses
1-(3,4-Dihydroxyphenyl)-2-(3-ethyl-1H-pyrazol-1-yl)ethanone Hydrochloride is a biochemical inhibitor of placental alkaline phosphatase (PLAP) and is used to elucidate the key biological functions and natural substrates of human PLAP.
Biological Activity
ml-095 (hydrochloride) is a specific plap inhibitor [1].alkaline phosphatases are hydrolase enzymes responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. there are three isozymes of alkaline phosphatases: placental alkaline phosphatase (plap), intestinal alkaline phosphatase (iap), and tissue non-specific alkaline phosphatase (tnap). placental alkaline phosphatase (plap) is highly expressed in primate placental tissue and the biological function is still unknown. however, plap-like enzymes are detected in serum of patients with primary testicular tumors, in particular seminoma and other cancers [1].ml-095 (cid-25067483) is a biochemical inhibitor of plap and will be useful to elucidate the key biological functions and natural substrates of human plap. ml095 is a specific plap inhibitor and inhibited plap, tnap and iap with ic50 values of 2.1, >100 and 53 μm, respectively. ml095 exhibited greater than 25-fold selectivity over tissue non-specific alkaline phosphatase (tnap) and intestinal alkaline phosphatase (iap) [1].
References
[1]. lanier m, cashman j, sergienko e, et al. placental alkaline phosphatase (plap) luminescent hts assay - probe 2.