ChemicalBook > CAS DataBase List > 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea

1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea

Product Name
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
CAS No.
1384424-80-9
Chemical Name
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
Synonyms
A-1070722;A 1070722, 10 mM in DMSO;N-(7-Methoxy-4-quinolinyl)-N’-[6-(trifluoromethyl)-2-pyridinyl]urea;1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea;N-(7-Methoxy-4-quinolinyl)-N'-[6-(trifluoromethyl)-2-pyridinyl]urea;Urea, N-(7-methoxy-4-quinolinyl)-N'-[6-(trifluoromethyl)-2-pyridinyl]-;A 1070722,Glycogen synthase kinase-3,inhibit,A1070722,Inhibitor,GSK-3,Glycogen synthase kinase 3,A-1070722
CBNumber
CB12751082
Molecular Formula
C17H13F3N4O2
Formula Weight
362.31
MOL File
1384424-80-9.mol
More
Less

1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Property

Boiling point:
412.5±45.0 °C(Predicted)
Density 
1.461±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble15mg/mL, clear
pka
11.57±0.43(Predicted)
form 
powder
color 
white to beige
More
Less

Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
36/37/39-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0863
Product name
A-1070722
Purity
≥98% (HPLC)
Packaging
5mg
Price
$88.2
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0863
Product name
A-1070722
Purity
≥98% (HPLC)
Packaging
25mg
Price
$425
Updated
2022/05/15
Cayman Chemical
Product number
29783
Product name
A-1070722
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
29783
Product name
A-1070722
Packaging
25mg
Price
$343
Updated
2024/03/01
Cayman Chemical
Product number
29783
Product name
A-1070722
Packaging
1mg
Price
$32
Updated
2024/03/01
More
Less

1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Chemical Properties,Usage,Production

Description

A-1070722 is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = <100 nM).

Uses

N-(7-Methoxy-4-quinolinyl)-N''-[6-(trifluoromethyl)-2-pyridinyl]urea is a neuroprotective agent and a glycogen synthase kinase-3 (GSK-3) inhibitor. GSK-3 is a conserved signaling enzyme that regulates a wide range of biological events (apoptosis, synaptic plasticity, axon formation, and neurogenesis). The enzyme has a conserved catalytic domain for binding ATP and a C-terminal domain with a conserved activation loop for the kinase activity. GSK-3 is a therapeutic target for treating neurodegenerative and psychiatric disorders.

in vivo

A 1070722 (10-20 mg/kg, 30 min before cocaine injection or 30 min prior to injection with saline (test day)) decreases spontaneous locomotion, inhibits the expression of conditioned activities but not the acquisition of conditioned activities in Cocaine-paired rats[2].

IC 50

GSK-3α: 0.6 nM (Ki); GSK-3β: 0.6 nM (Ki)

storage

Store at RT

References

[1] CHANTALLE MOOLMAN . Exploration of benzofuran-based compounds as potent and selective Plasmodium falciparum glycogen synthase kinase-3 (PfGSK-3) inhibitors[J]. Bioorganic Chemistry, 2021, 112: Article 104839. DOI: 10.1016/j.bioorg.2021.104839

1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Suppliers

China 41 United Kingdom 1 United States 11 USA 1 Global 54
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4989
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Abmole Bioscience Inc.
Tel
021-50967598 02150967598
Email
sales@abmole.cn
Country
China
ProdList
4494
Advantage
58

1384424-80-9, 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]ureaRelated Search:


  • 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
  • A-1070722
  • Urea, N-(7-methoxy-4-quinolinyl)-N'-[6-(trifluoromethyl)-2-pyridinyl]-
  • -[6-(trifluoromethyl)-2-pyridinyl]urea
  • N-(7-Methoxy-4-quinolinyl)-N&rsquo
  • N-(7-Methoxy-4-quinolinyl)-N'-[6-(trifluoromethyl)-2-pyridinyl]urea
  • A 1070722,Glycogen synthase kinase-3,inhibit,A1070722,Inhibitor,GSK-3,Glycogen synthase kinase 3,A-1070722
  • A 1070722, 10 mM in DMSO
  • 1384424-80-9