2-Methoxy-5-(trifluoromethyl)aniline

Product Name: 2-Methoxy-5-(trifluoromethyl)aniline
CAS No.: 349-65-5
Chemical Name: 2-Methoxy-5-(trifluoromethyl)aniline
Synonyms: 3-AMINO-4-METHOXYBENZOTRIFLUORIDE;BUTTPARK 50\01-75;Letermovir Intermediate 2;5-trifluoromethyl-o-anisidine;2-AMINO-4-TRIFLUOROMETHYLANISOLE;2-METHOXY-5-(TRIFLUOROMETHYL)ANILINE;6-methoxy-α,α,α-trifluoro-m-toluidine;2-METHOXY-5-TRIFLUOROMETHYL-PHENYLAMINE;2-Methoxy-5-(trifluoromethyl)aniline>2-Methoxy-5-(trifluoromethyl)aniline 96%
CBNumber: CB1277045
Molecular Formula: C8H8F3NO
Formula Weight: 191.15
MOL File: 349-65-5.mol

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2-Methoxy-5-(trifluoromethyl)aniline Property

Melting point:: 58-60 °C (lit.)
Boiling point:: 230.1±40.0 °C(Predicted)
Density: 1.2645 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 3.31±0.10(Predicted)
form: Crystalline Powder
color: Beige-gray to brown
BRN: 2835713
InChI: InChI=1S/C8H8F3NO/c1-13-7-3-2-5(4-6(7)12)8(9,10)11/h2-4H,12H2,1H3
InChIKey: RKUSRLUGUVDNKP-UHFFFAOYSA-N
SMILES: C1(N)=CC(C(F)(F)F)=CC=C1OC
CAS DataBase Reference: 349-65-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36-36/37/39
RIDADR: UN2811
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29222990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 336599
Product name: 2-Methoxy-5-(trifluoromethyl)aniline
Purity: 96%
Packaging: 5g
Price: $63.4
Updated: 2023/06/20

TCI Chemical

Product number: M2212
Product name: 2-Methoxy-5-(trifluoromethyl)aniline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $46
Updated: 2025/07/31

TCI Chemical

Product number: M2212
Product name: 2-Methoxy-5-(trifluoromethyl)aniline
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $182
Updated: 2025/07/31

TRC

Product number: M332478
Product name: 2-Methoxy-5-(trifluoromethyl)aniline
Packaging: 250mg
Price: $45
Updated: 2021/12/16

Oakwood

Product number: 003998
Product name: 3-Amino-4-methoxybenzotrifluoride
Purity: 97%
Packaging: 1g
Price: $10
Updated: 2021/12/16

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2-Methoxy-5-(trifluoromethyl)aniline Chemical Properties,Usage,Production

Chemical Properties

Beige-greyish to brownish crystalline powder

Uses

2-Methoxy-5-(trifluoromethyl)aniline may be used in chemical synthesis.

Definition

ChEBI: 2-Methoxy-5-(trifluoromethyl)aniline is a member of (trifluoromethyl)benzenes.

Synthesis

394-25-2

349-65-5

Example 51 General procedure for the synthesis of 4-(8-methoxy-5-(trifluoromethyl)quinazolin-2-ylamino)phenyl)(morpholino)methanone (Compound 500) PP028218.0002: Step 1. Prepare a mixture of 2-methoxy-5-(trifluoromethyl)aniline A. A methanolic solution of 4-methoxy-3-nitrobenzotrifluoride and 10% Pd/C catalyst (10% loading) was stirred overnight at room temperature in a hydrogen atmosphere. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad to remove the catalyst, and the filtrate was concentrated under reduced pressure and dried under vacuum to afford the target product 2-methoxy-5-(trifluoromethyl)aniline A in 99% yield as an off-white solid.ESI-MS m/z: 192.1 (MH+).

References

[1] Synthesis, 2006, # 19, p. 3316 - 3340
[2] Patent: WO2007/117607, 2007, A2. Location in patent: Page/Page column 363-364
[3] Journal of the American Chemical Society, 1952, vol. 74, p. 3011,3012
[4] Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1955, vol. 28, p. 969,972
[5] Chem.Abstr., 1956, p. 4880

2-Methoxy-5-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methoxy-5-(trifluoromethyl)aniline Suppliers

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View Lastest Price from 2-Methoxy-5-(trifluoromethyl)aniline manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 2-Methoxy-5-(trifluoromethyl)aniline
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-22

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Methoxy-5-(trifluoromethyl)aniline 349-65-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-22

Henan Fengda Chemical Co., Ltd

Product: 2-Methoxy-5-(trifluoromethyl)aniline 349-65-5
Price: US $10.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-28

349-65-5, 2-Methoxy-5-(trifluoromethyl)anilineRelated Search:

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Letermovir Intermediate 2

2-Methoxy-5-(trifluoromethyl)aniline&gt

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349-65-5

349-65-3

CH3OC6H3CF3NH2

C8H8F3NO

C8

Building Blocks

Amines

Organic Building Blocks

Nitrogen Compounds

Anilines, Aromatic Amines and Nitro Compounds

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