BIS(METHYLTHIO)GLIOTOXIN
- Product Name
- BIS(METHYLTHIO)GLIOTOXIN
- CAS No.
- 74149-38-5
- Chemical Name
- BIS(METHYLTHIO)GLIOTOXIN
- Synonyms
- FR-49175;BIS(METHYLTHIO)GLIOTOXIN;Bis(methylthio)gliotoxin (FR-49175);bis-dethio-bis(methylthio)gliotoxin;gliotoxin, bis-dethio-bis(methylthio)-;2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione;(3R)-2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3α,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione;Pyrazino[1,2-a]indole-1,4-dione, 2,3,5a,6,10,10a-hexahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-3,10a-bis(methylthio)-, (3R,5aS,6S,10aR)-
- CBNumber
- CB1288191
- Molecular Formula
- C15H20N2O4S2
- Formula Weight
- 356.46
- MOL File
- 74149-38-5.mol
BIS(METHYLTHIO)GLIOTOXIN Property
- Boiling point:
- 669.6±55.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- White solid.
- pka
- 12.69±0.60(Predicted)
- color
- Off-White to Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P403Store in a well-ventilated place.
N-Bromosuccinimide Price
- Product number
- J67499
- Product name
- Bis(methylthio)gliotoxin, 99%
- Packaging
- 1mg
- Price
- $290
- Updated
- 2023/06/20
- Product number
- 26271
- Product name
- Bis(methylthio)gliotoxin
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 26271
- Product name
- Bis(methylthio)gliotoxin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- B485948
- Product name
- Bis(methylthio)gliotoxin(FR-49175)
- Packaging
- 1mg
- Price
- $215
- Updated
- 2021/12/16
- Product number
- B485948
- Product name
- Bis(methylthio)gliotoxin(FR-49175)
- Packaging
- 2.5mg
- Price
- $525
- Updated
- 2021/12/16
BIS(METHYLTHIO)GLIOTOXIN Chemical Properties,Usage,Production
Description
Bis(methylthio)gliotoxin is a fungal metabolite originally isolated from G. deliquescens that has diverse biological activities. It inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC50s = 8.4 and 84.2 μM, respectively) but has no effect on arachidonic acid- or ADP-induced platelet aggregation (IC50s = >400 μM). Bis(methylthio)gliotoxin inhibits growth of HCT116 colon cancer cells (IC50 = 23.56 μM). It inhibits PAF-induced bronchoconstriction in guinea pigs when administered at a dose of 0.1 mg/kg and is less toxic to mice (LD50 = >500 mg/kg) than gliotoxin . Bis(methylthio)gliotoxin has been used as a serum biomarker in patients infected with invasive aspergillosis.
Uses
Bis(methylthio)gliotoxin (FR-49175) is an antiphagocytic metabolite.
Enzyme inhibitor
This naturally occurring indole derivative (FW = 356.47 g/mol; CAS 74149- 38-5), also known as bis(methylthio)gliotoxin and dimethylgliotoxin, is a platelet-acivating factor (PAF) antagonist that inhibits PAF-induced platelet aggregation. The parent compound, gliotoxin is a dual inhibitor of famesyltransferase and geranylgeranyl-transferase. Bisdethiobis(methylthio)gliotoxin is a minor metabolite of Gliocladium deliquescens, Radiocarbon tracer experiments showed it is formed, apparently irreversibly, from gliotoxin. It has also been synthesized from gliotoxin by reduction and methylation. Bisdethio-bis(methylthio)gliotoxin also binds Cu+ and Ag+ ions.
BIS(METHYLTHIO)GLIOTOXIN Preparation Products And Raw materials
Raw materials
Preparation Products
BIS(METHYLTHIO)GLIOTOXIN Suppliers
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