BIS(METHYLTHIO)GLIOTOXIN

Product Name: BIS(METHYLTHIO)GLIOTOXIN
CAS No.: 74149-38-5
Chemical Name: BIS(METHYLTHIO)GLIOTOXIN
Synonyms: FR-49175;BIS(METHYLTHIO)GLIOTOXIN;Bis(methylthio)gliotoxin (FR-49175);bis-dethio-bis(methylthio)gliotoxin;gliotoxin, bis-dethio-bis(methylthio)-;2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione;(3R)-2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3α,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione;Pyrazino[1,2-a]indole-1,4-dione, 2,3,5a,6,10,10a-hexahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-3,10a-bis(methylthio)-, (3R,5aS,6S,10aR)-
CBNumber: CB1288191
Molecular Formula: C15H20N2O4S2
Formula Weight: 356.46
MOL File: 74149-38-5.mol

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BIS(METHYLTHIO)GLIOTOXIN Property

Boiling point:: 669.6±55.0 °C(Predicted)
Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: White solid.
pka: 12.69±0.60(Predicted)
color: Off-White to Yellow

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J67499
Product name: Bis(methylthio)gliotoxin, 99%
Packaging: 1mg
Price: $290
Updated: 2023/06/20

Cayman Chemical

Product number: 26271
Product name: Bis(methylthio)gliotoxin
Purity: ≥95%
Packaging: 500μg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 26271
Product name: Bis(methylthio)gliotoxin
Purity: ≥95%
Packaging: 1mg
Price: $161
Updated: 2024/03/01

TRC

Product number: B485948
Product name: Bis(methylthio)gliotoxin(FR-49175)
Packaging: 1mg
Price: $215
Updated: 2021/12/16

TRC

Product number: B485948
Product name: Bis(methylthio)gliotoxin(FR-49175)
Packaging: 2.5mg
Price: $525
Updated: 2021/12/16

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BIS(METHYLTHIO)GLIOTOXIN Chemical Properties,Usage,Production

Description

Bis(methylthio)gliotoxin is a fungal metabolite originally isolated from G. deliquescens that has diverse biological activities. It inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC₅₀s = 8.4 and 84.2 μM, respectively) but has no effect on arachidonic acid- or ADP-induced platelet aggregation (IC₅₀s = >400 μM). Bis(methylthio)gliotoxin inhibits growth of HCT116 colon cancer cells (IC₅₀ = 23.56 μM). It inhibits PAF-induced bronchoconstriction in guinea pigs when administered at a dose of 0.1 mg/kg and is less toxic to mice (LD₅₀ = >500 mg/kg) than gliotoxin . Bis(methylthio)gliotoxin has been used as a serum biomarker in patients infected with invasive aspergillosis.

Uses

Bis(methylthio)gliotoxin (FR-49175) is an antiphagocytic metabolite.

Enzyme inhibitor

This naturally occurring indole derivative (FW = 356.47 g/mol; CAS 74149- 38-5), also known as bis(methylthio)gliotoxin and dimethylgliotoxin, is a platelet-acivating factor (PAF) antagonist that inhibits PAF-induced platelet aggregation. The parent compound, gliotoxin is a dual inhibitor of famesyltransferase and geranylgeranyl-transferase. Bisdethiobis(methylthio)gliotoxin is a minor metabolite of Gliocladium deliquescens, Radiocarbon tracer experiments showed it is formed, apparently irreversibly, from gliotoxin. It has also been synthesized from gliotoxin by reduction and methylation. Bisdethio-bis(methylthio)gliotoxin also binds Cu+ and Ag+ ions.

BIS(METHYLTHIO)GLIOTOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

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BIS(METHYLTHIO)GLIOTOXIN Suppliers

China 19 Germany 2 Switzerland 1 United States 8 Global 30

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
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Country: China
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Country: United States
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Shanghai YuanYe Biotechnology Co., Ltd.

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Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Energy Chemical

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cjbscvictory

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Beijing PUXI Technology Co., Ltd

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Shanghai Moqi Biological Technology Co., LTD

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74149-38-5, BIS(METHYLTHIO)GLIOTOXINRelated Search:

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gliotoxin, bis-dethio-bis(methylthio)-

(3R)-2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3α,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione

2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione

Bis(methylthio)gliotoxin (FR-49175)

BIS(METHYLTHIO)GLIOTOXIN

FR-49175

bis-dethio-bis(methylthio)gliotoxin

Pyrazino[1,2-a]indole-1,4-dione, 2,3,5a,6,10,10a-hexahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-3,10a-bis(methylthio)-, (3R,5aS,6S,10aR)-

74149-38-5

C15H20N2O4S2