ChemicalBook > CAS DataBase List > Choline kinase alpha
Choline kinase alpha
- Product Name
- Choline kinase alpha
- Chemical Name
- Choline kinase alpha
- Synonyms
- CKI;CHK;CTK;Ntk;CHKA;MATK;CKIe;CK1-ω;KC1AL;CK1G1
- CBNumber
- CB12895980
- Formula Weight
- 0
- MOL File
- Mol file
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Choline kinase alpha Property
- storage temp.
- -70°C
- form
- buffered aqueous glycerol solution
- biological source
- rabbit
- Specific Activity
- 102-138nmol/min·mg
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Safety
- WGK Germany
- 1
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SRP5314
- Product name
- CK1γ1, active, GST tagged human
- Purity
- PRECISIO<SUP>®</SUP>, recombinant, expressed in baculovirus infected <I>Sf</I>9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
- Packaging
- 10 μg
- Price
- $401
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- SAB4502222
- Product name
- Anti-CKI-γ1 antibody produced in rabbit
- Purity
- affinity isolated antibody
- Packaging
- 100 μg
- Price
- $392
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- SAB4500511
- Product name
- Anti-CKI-ε antibody produced in rabbit
- Purity
- affinity isolated antibody
- Packaging
- 100μG
- Price
- $392
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- SAB4500317
- Product name
- Anti-CKI-α1 antibody produced in rabbit
- Purity
- affinity isolated antibody
- Packaging
- 100μG
- Price
- $522
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- HPA066547
- Product name
- Anti-MATK antibody produced in rabbit
- Purity
- Prestige Antibodies<SUP>®</SUP> Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
- Packaging
- 100 μL
- Price
- $598
- Updated
- 2025/07/31
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Choline kinase alpha Chemical Properties,Usage,Production
Uses
GST tagged active CK1α1 has been used in downstream coprecipitation and mass spectrometry to demonstrate the phosphorylation of the Wnt regulator, Jade-1, by CK1α1.
General Description
Casein kinase 1 α1 (CK1α1) is a member of the CK1 family of serine/threonine protein kinases, which play an important role in diverse cell processes. CK1α1 can regulate Smo cell surface accumulation and activity in response to hedgehog. CK1α1 phosphorylates Smo at several sites and phosphorylation-deficient forms of Smo fail to accumulate on the cell surface and are unable to transduce the hedgehog signal. CK1α1 dynamically associates with the CARMA1-BCL10-MALT1 (CBM) complex on T cell receptor engagement to participate in cytokine production and lymphocyte proliferation. CK1α1 can form complex with the E3 ubiquitin-protein ligase MDM2, which then regulates the stability of p53 and E2F-1 transcription factors.
Biological Activity
MATK (megakaryocyte-associated tyrosine kinase) is involved in the development of the central nervous system (CNS) through MAPK signaling pathway. In neural cells, it triggers the MAPK activity via Ras-mediated signaling in a Src-independent manner. Studies have been reported th at MATK may have impact on the tumorigenesis and in the terminal differentiation of neurons within the CNS.
Choline kinase alpha Preparation Products And Raw materials
Raw materials
Preparation Products
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