ChemicalBook > CAS DataBase List > DELAVIRDINE, MESYLATE

DELAVIRDINE, MESYLATE

Product Name: DELAVIRDINE, MESYLATE
CAS No.: 147221-93-0
Chemical Name: DELAVIRDINE, MESYLATE
Synonyms: C08087;U-90152S;U 90152 (mesylate);elavirdinemesylate;Seebio Delavirdine;Delavirdine Mesylat;Delavirdine mesilate;BHAP-U 90152 (mesylate);Delavirdine methane sulfonate;DELAVIRDINE (MESYLATE);U 90152
CBNumber: CB1292152
Molecular Formula: C23H32N6O6S2
Formula Weight: 552.67
MOL File: 147221-93-0.mol

Less

DELAVIRDINE, MESYLATE Property

Melting point:: 118-120°C
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO: >5mg/mL
form: powder
color: white to tan
CAS DataBase Reference: 147221-93-0

Less

Safety

WGK Germany: 3
Hazardous Substances Data: 147221-93-0(Hazardous Substances Data)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0180
Product name: Delavirdine mesylate
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $154
Updated: 2025/07/31

Sigma-Aldrich

Product number: PZ0180
Product name: Delavirdine mesylate
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $408.1
Updated: 2025/07/31

Cayman Chemical

Product number: 24026
Product name: Delavirdine (mesylate)
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 24026
Product name: Delavirdine (mesylate)
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 24026
Product name: Delavirdine (mesylate)
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Less

DELAVIRDINE, MESYLATE Chemical Properties,Usage,Production

Description

Rescriptor was launched in the US for HIV positive individuals. It can be prepared in seven steps from 2-chloro-3-nitropyridine and piperazine. Rescriptor is a member of the bis(heteroaryl)piperazine (BHAP) class of non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs) of which it is a second generation drug. It acts exclusively as an allosteric mixed inhibitor of both RNA- and DNA-directed polymerase domains of RT and has a much higher binding affintiy for the enzymesubstrate complex than for the free enzyme. Rescriptor does not inhibit RNase H activity of RT. It prevented the spread of HIV significantly longer than AZT. Development of resistance to Rescriptor can occur, however the mutated strain becomes more vulnerable to other members of the NNRTIs. It is metabolized in the liver by CYP3A.

Chemical Properties

Light Brown Solid

Originator

Pharmacia ＆ Upjohn (US)

Uses

A bisheteroarylpiperazine (BHAP) reverse transcriptase inhibitor.

Definition

ChEBI: The monomethanesulfonic acid salt of delavirdine, a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. Viral resistance emerges rapidly when delavirdine is used alone, so it is therefore used (as the methanesulfonic acid salt) with other antiretrovirals for combination therapy of HIV infection.

Manufacturing Process

5-Nitroindole-2-carboxylic acid (0.86 g), 1-[3-(N-isopropyl)amino-2- pyridinyl]piperazine (0.43 g), 1-(ethyl)-3-(dimethylaminopropyl)carbodiimide (0.45 g) and THF (4 ml), were stirred at 20-25°C for 3 hr; then the reaction mixture was dissolved in chloroform (50 ml) and extracted with saturated aqueous sodium bicarbonate, saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification by flash column chromatography (200 g silica) eluting with ethyl acetate/hexane (50/50), the appropriate fractions were pooled and concentrated to give 1-[5-nitroindolyl2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine, mp 153°- 154°C.
1-[5-Nitroindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2- pyridinyl]piperazine (1.0 g) was dissolved in ethanol (60 ml) and THF (60 ml) and palladium on carbon (10%, 0.15 g) was added. The reaction mixture was hydrogenated at 40 psi for 14 hr, then filtered through celite and concentrated under reduced pressure. Purification by flash chromatography, eluting with ethyl acetate/hexane (50/50) pooling and concentrating the appropriate fractions gave 1-[5-aminoindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2- pyridinyl]piperazine, mp 212°-214°C.
1-[5-Aminoindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2- pyridinyl]piperazine (0.075 mg) was dissolved in methylene chloride (0.4 ml) and pyridine (0.016 g) was added and the reaction is cooled to 0°C. Then methanesulfonyl chloride (0.023 g) was added. After 2.5 hr of stirring, the reaction was diluted with chloroform and washed with saturated aqueous sodium bicarbonate, saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The concentrate was dissolved in the minimum amount of chloroform and passed through a small plug of silica gel and then it is recrystallized with ethyl acetate/hexane to provide the 1-[5- methansulfoneamidolyl-2-carbonyl]-4-[3-(1-methylethylenamino)-2- pyridinyl]piperazine, mp 226°-228°C.
The mesylate salt may be formed by dissolving the free base in methanol and methanesulfonic acid (1 eq) is added.

brand name

Rescriptor (Agouron).

Therapeutic Function

Antiviral, Anti-HIV virus agent

DELAVIRDINE, MESYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

DELAVIRDINE, MESYLATE Suppliers

Canada 1 China 90 Europe 2 Germany 1 India 2 United Kingdom 5 United States 17 Global 118

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8065
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Nanjing Chalf-Pharm Technology Co., Ltd.

Tel: 025-57018978 18251899859
Fax: 025-57018008
Email: sales@chalf-pharm.com
Country: China
ProdList: 5674
Advantage: 50

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 984
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12475
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29759
Advantage: 68

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Henan Anky Chemical Technology Co., Ltd.

Tel: 17836913271
Fax: 0374-8348899
Email: 3224305243@qq.com
Country: China
ProdList: 2944
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3277
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Aishilun biotechnology (Shanghai) co., LTD

Tel: 021-50676523 18019098996
Email: info@acelybio.com
Country: China
ProdList: 3960
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55055611 18137792234
Fax: QQ：3002694073
Email: 3002694073@qq.com
Country: China
ProdList: 9987
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Labnetwork lnc.

Tel: +86-27-50766799 +8618062016861
Email: contact@labnetwork.com
Country: China
ProdList: 19987
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

HUNAN CHEMFISH SCIENTIFIC CO.,LTD

Tel: +86-0731-85567275 13298656710
Fax: QQ:3554193828
Email: sales05@chemfish.com
Country: China
ProdList: 7448
Advantage: 58

Beijing xinyanhui pharmaceutical research and development co., LTD

Tel: 13969155946
Email: 1461866103@qq.com
Country: China
ProdList: 16111
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 18438616290
Email: lanwu@univ-bio.com
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Nanjing shengyilai Chemical Co., Ltd

Tel: 19951936396
Email: 3158688292@qq.com
Country: China
ProdList: 4856
Advantage: 58

Cangzhou Pintuo Biotechnology Co., Ltd.

Tel: 15231732623
Email: 1979763395@qq.com
Country: China
ProdList: 187
Advantage: 58

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4195
Advantage: 58

Zhende Chemical Technology (Shanghai) Co., Ltd.

Tel: 15601952568
Fax: 3004479441
Email: sales4@myuchem.com
Country: China
ProdList: 2988
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7986
Advantage: 58

cjbscvictory

Tel: 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10503
Advantage: 58

Hubei Wande Chemical Co., Ltd

Tel: 027-027-59210159 15377098680
Fax: 027-59210159
Email: 1148280011@qq.com
Country: China
ProdList: 9835
Advantage: 58

Abmole Bioscience Inc.

Tel: 021-50967598 02150967598
Email: sales@abmole.cn
Country: China
ProdList: 4494
Advantage: 58

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 7938
Advantage: 58

ChemeGen

Tel: 18818260767
Fax: QQ 3610331285
Email: 2625930290@qq.com
Country: China
ProdList: 6973
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9960
Advantage: 58

Hubei Weideli Chemical Reagent Co.，Ltd.

Tel: 133-3998-5473 13339985473
Email: C13339985473@163.com
Country: China
ProdList: 4991
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Hubei Wanye Zhongcheng Chemical Reagent Co., Ltd.

Tel: 18671296875
Email: 1205035102@qq.com
Country: China
ProdList: 4302
Advantage: 58

Xianning Shen Lan Biomedical Research and Development Co., Ltd.

Tel: 18171815831
Email: 1341138380@qq.com
Country: China
ProdList: 4310
Advantage: 58

Less

View Lastest Price from DELAVIRDINE, MESYLATE manufacturers

Career Henan Chemical Co

Product: DELAVIRDINE, MESYLATE 147221-93-0
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

147221-93-0, DELAVIRDINE, MESYLATERelated Search:

DELAVIRDINE 2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE 3-PYRIDYLAMINE, N-(1-METHYLETHYL)-2-(1-PIPERAZINYL)-,DIHYDROCHLORIDE MONOHYDRATE 3-Pyridinamine,2-(1-piperazinyl)-(9CI) 3-(Ethylamino)-2-(1-piperazinyl)pyridine DELAVIRDINE, MESYLATE

DELAVIRDINE (MESYLATE);U 90152

1-[3-[(1-Methylethyl)amino]-2-pyridinyl]-4-[[5-[(methylsulfonyl)amino]-1H-indol-2-yl]carbonyl]-piperazine monomethanesulfonate

DELAVIRDINE MESYLATE (U 90152 MESYLATE)

C08087

Delavirdine mesilate

MethanesulfonaMide, N-[2-[[4-[3-[(1-Methylethyl)aMino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]-, Methanesulfonate

N-[2-[[4-[3-[(1-Methylethyl)aMino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]MethanesulfonaMide Methanesulfonate

Delavirdine methane sulfonate

N-[2-[[4-[3-[(1-Methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]methanesulfonamide mesylate

U-90152S

BHAP-U 90152 (mesylate)

U 90152 (mesylate)

Delavirdine Mesylat

N-(2-(4-(3-(Isopropylamino)pyridin-2-yl)piperazine-1-carbonyl)-1H-indol-5-yl)methanesulfonamide methanesulfonate

elavirdinemesylate

Delavirdine mesylate, 10 mM in DMSO

Seebio Delavirdine

147221-93-0

C22H28N6O3SCH4SO3

C22H28N6O3SCH4O3S

C23H32N6O6S2

Anti-viral Compounds

Anti-virals

Inhibitors

Intermediates & Fine Chemicals

Non-nucleoside Reverse Transcriptase

Pharmaceuticals