2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE

Product Name: 2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE
CAS No.: 5028-17-1
Chemical Name: 2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE
Synonyms: AKOS B034160;2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE;1-(3-amino-2-pyridyl)-4-methyl-piperazin;1-(3-amino-2-pyridyl)-4-methylpiperazine;2-(4-METHYL-1-PIPERAZINYL)-3-PYRIDINAMINE;3-Pyridinamine, 2-(4-methyl-1-piperazinyl)-;2-(4-methyl-piperazin-1-yl)-pyridin-3-ylamine
CBNumber: CB9693676
Molecular Formula: C10H16N4
Formula Weight: 192.26
MOL File: 5028-17-1.mol

More

Less

2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE Property

Melting point:: 112-114°C
Boiling point:: 361.6±42.0 °C(Predicted)
Density: 1.142±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 9.35±0.29(Predicted)
Appearance: Off-white to pink Solid

More

Less

Safety

HazardClass: IRRITANT
HS Code: 2933599590

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

SynQuest Laboratories

Product number: 3H30-1-MG
Product name: 2-(4-Methylpiperazin-1-yl)pyridin-3-amine
Purity: 95%
Packaging: 1g
Price: $328
Updated: 2021/12/16

Matrix Scientific

Product number: 044239
Product name: 2-(4-Methylpiperazino)-3-pyridinamine
Purity: >95%
Packaging: 500mg
Price: $362
Updated: 2021/12/16

Matrix Scientific

Product number: 044239
Product name: 2-(4-Methylpiperazino)-3-pyridinamine
Purity: >95%
Packaging: 1g
Price: $454
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0018844
Product name: 2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE
Purity: 95.00%
Packaging: 1G
Price: $866.13
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-1-MG
Product name: 2-(4-Methylpiperazin-1-yl)pyridin-3-amine
Purity: 95%
Packaging: 5G
Price: $912
Updated: 2021/12/16

More

Less

2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE Chemical Properties,Usage,Production

Synthesis

5028-15-9

5028-17-1

General procedure for the synthesis of 2-(4-methylpiperazinyl)-3-aminopyridine from 1-methyl-4-(3-nitro-2-pyridinyl)piperazine: preparation of 2-(4-methylpiperazin-1-yl)-3-nitropyridine (PP26, 0.50 g, 2.25 mmol), ammonium formate (1.00 g, 15.85 mmol) and 10% Pd/C (0.050 g) ) solution in methanol (20 mL). The reaction mixture was stirred at room temperature for 1 h. The filtrate was subsequently filtered through diatomaceous earth (Celite?) and concentrated. The residue was dissolved in ethyl acetate, washed sequentially with aqueous potassium carbonate and brine, dried over anhydrous magnesium sulfate and concentrated to give 0.35 g (81% yield) of 2-(4-methylpiperazinyl)-3-aminopyridine (PP24) as a violet oil, which was used directly in the next reaction without further purification. The product was confirmed by NMR hydrogen spectroscopy (CDCl3): δ 7.77 (dd, J = 4.6, 1.7 Hz, 1H), 6.90 (dd, J = 7.5, 1.7 Hz, 1H), 6.79 (dd, J = 7.9, 5.0 Hz, 1H), 3.71 (br s, 2H), 3.15 (br s, 4H), 2.57 (br s, 4H) , 2.34 (s, 3H).

References

[1] Patent: WO2006/48727, 2006, A1. Location in patent: Page/Page column 72-73
[2] Patent: WO2013/40215, 2013, A1. Location in patent: Paragraph 00304
[3] Patent: WO2018/75858, 2018, A1. Location in patent: Paragraph 0335; 0337

2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE Suppliers

China 29 Germany 2 India 2 The Netherlands 1 United Kingdom 1 United States 5 Global 40

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

ShangHai KenEn Chemical Technology Co., Ltd.

Tel: 13120367189
Fax: 021-50315529
Email: mychess007@163.com
Country: China
ProdList: 1994
Advantage: 55

ShangHai AmK Pharmaceutical Technology Co., Ltd.

Tel: 微信 17321281695 18019252918
Fax: 17321281695
Email: sale@amkchem.com
Country: China
ProdList: 15136
Advantage: 55

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Shanghai Brain Biotechnology Co., Ltd.

Tel: 13564638271
Fax: 021-68948280
Email: shhjiang1977@163.com
Country: China
ProdList: 2987
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Sichuan BaiPeng Biotechnology Co., Ltd.

Tel: 028-65791793 18140026355
Fax: QQ568470422
Email: 568470422@qq.com
Country: China
ProdList: 9997
Advantage: 58

Wuxi AppTec

Tel: 022-59987777 13552403979
Email: jia_guoqiang@wuxiapptec.com
Country: China
ProdList: 22345
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: (5)02557626880
Email: dt3@aikonchem.com
Country: China
ProdList: 15493
Advantage: 58

5028-17-1, 2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINERelated Search:

DELAVIRDINE 1-Benzyl-4-(3-nitropyridin-2-yl)piperazine atevirdine DELAVIRDINE, MESYLATE 2-[4-(3-NITRO-2-PYRIDYL)PIPERAZINO]ETHAN-1-OL 2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE N-(2-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)-3-PYRIDINYL)-4-FLUOROBENZENECARBOXAMIDE 2-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)-3-PYRIDINAMINIUM CHLORIDE 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-4-[3-(1H-PYRROL-1-YL)-2-PYRIDINYL]PIPERAZINE N-(2-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)-3-PYRIDINYL)-4-METHYLBENZENECARBOXAMIDE 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-4-(3-NITRO-2-PYRIDINYL)PIPERAZINE N-(2-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)-3-PYRIDINYL)-2-THIOPHENECARBOXAMIDE N-(2-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)-3-PYRIDINYL)(TRIFLUORO)METHANESULFONAMIDE ETHYL 4-(3-NITRO-2-PYRIDINYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE 1-(3-nitro-2-pyridinyl)-4-phenylpiperazine AKOS B034172 METHYL 3-NITRO-4-[4-(3-NITRO-2-PYRIDINYL)PIPERAZINO]BENZENECARBOXYLATE 1,4-BIS(3-NITRO-2-PYRIDINYL)PIPERAZINE

1-(3-amino-2-pyridyl)-4-methyl-piperazin

AKOS B034160

2-(4-methyl-piperazin-1-yl)-pyridin-3-ylamine

1-(3-amino-2-pyridyl)-4-methylpiperazine

2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE

2-(4-METHYL-1-PIPERAZINYL)-3-PYRIDINAMINE

3-Pyridinamine, 2-(4-methyl-1-piperazinyl)-

5028-17-1