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2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE

Product Name
2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE
CAS No.
5028-17-1
Chemical Name
2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE
Synonyms
AKOS B034160;2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE;1-(3-amino-2-pyridyl)-4-methyl-piperazin;1-(3-amino-2-pyridyl)-4-methylpiperazine;2-(4-METHYL-1-PIPERAZINYL)-3-PYRIDINAMINE;3-Pyridinamine, 2-(4-methyl-1-piperazinyl)-;2-(4-methyl-piperazin-1-yl)-pyridin-3-ylamine
CBNumber
CB9693676
Molecular Formula
C10H16N4
Formula Weight
192.26
MOL File
5028-17-1.mol
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2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE Property

Melting point:
112-114°C
Boiling point:
361.6±42.0 °C(Predicted)
Density 
1.142±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
9.35±0.29(Predicted)
Appearance
Off-white to pink Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific
Product number
044239
Product name
2-(4-Methylpiperazino)-3-pyridinamine
Purity
>95%
Packaging
1g
Price
$454
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0018844
Product name
2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE
Purity
95.00%
Packaging
1G
Price
$866.13
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-1-MG
Product name
2-(4-Methylpiperazin-1-yl)pyridin-3-amine
Purity
95%
Packaging
5G
Price
$912
Updated
2021/12/16
Matrix Scientific
Product number
044239
Product name
2-(4-Methylpiperazino)-3-pyridinamine
Purity
>95%
Packaging
5g
Price
$1040
Updated
2021/12/16
AK Scientific
Product number
4382AE
Product name
2-(4-Methylpiperazino)-3-pyridinamine
Packaging
10g
Price
$1091
Updated
2021/12/16
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2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE Chemical Properties,Usage,Production

Synthesis

5028-15-9

5028-17-1

General procedure for the synthesis of 2-(4-methylpiperazinyl)-3-aminopyridine from 1-methyl-4-(3-nitro-2-pyridinyl)piperazine: preparation of 2-(4-methylpiperazin-1-yl)-3-nitropyridine (PP26, 0.50 g, 2.25 mmol), ammonium formate (1.00 g, 15.85 mmol) and 10% Pd/C (0.050 g) ) solution in methanol (20 mL). The reaction mixture was stirred at room temperature for 1 h. The filtrate was subsequently filtered through diatomaceous earth (Celite?) and concentrated. The residue was dissolved in ethyl acetate, washed sequentially with aqueous potassium carbonate and brine, dried over anhydrous magnesium sulfate and concentrated to give 0.35 g (81% yield) of 2-(4-methylpiperazinyl)-3-aminopyridine (PP24) as a violet oil, which was used directly in the next reaction without further purification. The product was confirmed by NMR hydrogen spectroscopy (CDCl3): δ 7.77 (dd, J = 4.6, 1.7 Hz, 1H), 6.90 (dd, J = 7.5, 1.7 Hz, 1H), 6.79 (dd, J = 7.9, 5.0 Hz, 1H), 3.71 (br s, 2H), 3.15 (br s, 4H), 2.57 (br s, 4H) , 2.34 (s, 3H).

References

[1] Patent: WO2006/48727, 2006, A1. Location in patent: Page/Page column 72-73
[2] Patent: WO2013/40215, 2013, A1. Location in patent: Paragraph 00304
[3] Patent: WO2018/75858, 2018, A1. Location in patent: Paragraph 0335; 0337

2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE Suppliers

China 29 Germany 2 India 2 The Netherlands 1 United Kingdom 1 United States 5 Global 40
AKos Consulting & Solutions GmbH
Tel
--
Fax
--
Email
akos@akosgmbh.de
Country
Germany
ProdList
6717
Advantage
72
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75

5028-17-1, 2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINERelated Search:

DELAVIRDINE 1-Benzyl-4-(3-nitropyridin-2-yl)piperazine atevirdine DELAVIRDINE, MESYLATE 2-[4-(3-NITRO-2-PYRIDYL)PIPERAZINO]ETHAN-1-OL 2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE N-(2-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)-3-PYRIDINYL)-4-FLUOROBENZENECARBOXAMIDE 2-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)-3-PYRIDINAMINIUM CHLORIDE 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-4-[3-(1H-PYRROL-1-YL)-2-PYRIDINYL]PIPERAZINE N-(2-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)-3-PYRIDINYL)-4-METHYLBENZENECARBOXAMIDE 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-4-(3-NITRO-2-PYRIDINYL)PIPERAZINE N-(2-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)-3-PYRIDINYL)-2-THIOPHENECARBOXAMIDE N-(2-(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)-3-PYRIDINYL)(TRIFLUORO)METHANESULFONAMIDE ETHYL 4-(3-NITRO-2-PYRIDINYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE 1-(3-nitro-2-pyridinyl)-4-phenylpiperazine AKOS B034172 METHYL 3-NITRO-4-[4-(3-NITRO-2-PYRIDINYL)PIPERAZINO]BENZENECARBOXYLATE 1,4-BIS(3-NITRO-2-PYRIDINYL)PIPERAZINE

  • 1-(3-amino-2-pyridyl)-4-methyl-piperazin
  • AKOS B034160
  • 2-(4-methyl-piperazin-1-yl)-pyridin-3-ylamine
  • 1-(3-amino-2-pyridyl)-4-methylpiperazine
  • 2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE
  • 2-(4-METHYL-1-PIPERAZINYL)-3-PYRIDINAMINE
  • 3-Pyridinamine, 2-(4-methyl-1-piperazinyl)-
  • 5028-17-1