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atevirdine

Product Name
atevirdine
CAS No.
136816-75-6
Chemical Name
atevirdine
Synonyms
atevirdine;[4-[3-(ethylamino)pyridin-2-yl]piperazin-1-yl]-(5-methoxy-1H-indol-2-yl)methanone;Methanone, [4-[3-(ethylaMino)-2-pyridinyl]-1-piperazinyl](5-Methoxy-1H-indol-2-yl)-
CBNumber
CB91074739
Molecular Formula
C21H25N5O2
Formula Weight
379.46
MOL File
136816-75-6.mol
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atevirdine Property

Melting point:
153-154°
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0010741
Product name
ATEVIRDINE
Purity
95.00%
Packaging
5MG
Price
$504.6
Updated
2021/12/16
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atevirdine Chemical Properties,Usage,Production

Originator

Atevirdine,Upjohn

Uses

Antiviral.

Manufacturing Process

1-[5-Methoxyindolyl-2-carbonyl]-4-[3-(ethylamino)-2-pyridinyl]piperazine:
1,1'-Carbonyldiimidazole (0.55 g) is added to a 20°-25°C solution of 5- methoxyindole-2-carboxylic acid (0.59 g) in tetrahydrofuran (7.0 ml). After stirring 1 hour, the reaction is transferred via cannnula into a solution of 1-(3- N-ethylamino-2-pyridinyl)piperazine (0.70 g) in tetrahydrofuran (7 ml) at - 12°C (ice/acetone bath). The reaction is stirred at -10°C for 30 minutes, then slowly warmed to 20°-25°C and stirred a further 18 hours. After diluting with ether (60 ml), the mixture is washed with saturated aqueous sodium bicarbonate (70 ml), saline (70 ml) and dried over anhydrous sodium sulfate. The mixture is concentrated under reduced pressure to a residue which is purified by flash chromatography (2 cm x 20 cm) eluting with methanol/chloroform (2/98) to give the title compound, mp 153°-154°C.
1-[5-Methoxyindolyl-2-carbonyl]-4-[3-(ethylamino)-2-pyridinyl]piperazine hydrochloride:
1-(Ethyl)-3-(dimethylaminopropyl)carbodiimide (1.25 g) is added to a solution of 1-(3-ethyl-2-pyridinyl)piperazine (1.12 g) in THF (15 ml). The reaction is stirred at 20°-25°C for 3 hr, then it is dissolved in chloroform (50 ml) and extracted with saturated aqueous sodium bicarbonate, saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification by flash column chromatography (200 g silica) eluting with ethyl acetate/hexane (50/50), the appropriate fractions are pooled and concentrated to give the title compound, The product is dissolved in methanol (150 ml) with heating, cooled to 20°-25°C and chlorotrimethylsilane (4.70 mmol) is added. The mixture is concentrated to half-volume, ether is added until cloudy and the flask is stored at 0°C overnight. Filtration gives the hydrochloride salt, MP: 194°-195°C.
The mesylate salt is formed by dissolving the free base in methanol and by adding methanesulfonic acid (1 eq). The solution is diluted with diethyl ether until the salt crystallizes out of solution. The crystals are collected and dried to afford the mesyl salt of the title compound, MP: 215°-216°C.

Therapeutic Function

Antiviral

atevirdine Preparation Products And Raw materials

Raw materials

Preparation Products

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atevirdine Suppliers

LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
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Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
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58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ:65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7266
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Wuxi Donghe Pharmaceutical Technology Co., Ltd.
Tel
63313187 15358055255
Fax
QQ:63313187
Email
63313187@qq.com
Country
China
ProdList
1988
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
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58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11974
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58
Shanghai Juankai Biopharma Co., Ltd
Tel
15052267297 15052267297
Email
630819472@qq.com
Country
China
ProdList
64
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ATK CHEMICAL COMPANY LIMITED
Tel
+undefined-21-51877795
Fax
+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
Country
China
ProdList
32957
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136816-75-6, atevirdineRelated Search:


  • atevirdine
  • Methanone, [4-[3-(ethylaMino)-2-pyridinyl]-1-piperazinyl](5-Methoxy-1H-indol-2-yl)-
  • [4-[3-(ethylamino)pyridin-2-yl]piperazin-1-yl]-(5-methoxy-1H-indol-2-yl)methanone
  • 136816-75-6