Health Benifits Tomatine Toxin Symptoms
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TOMATINE

Health Benifits Tomatine Toxin Symptoms
Product Name
TOMATINE
CAS No.
17406-45-0
Chemical Name
TOMATINE
Synonyms
TOMATIN;omatine;Tomatie;TOMATINE;NSC 9223;a-Tomatine;NSC 234440;LYOCPERSICIN;LYCOPERSICIN;LYCOPERISCIN
CBNumber
CB1292394
Molecular Formula
C50H83NO21
Formula Weight
1034.19
MOL File
17406-45-0.mol
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TOMATINE Property

Melting point:
300-305°C
alpha 
D20 -18° (c = 0.55 in pyridine)
Boiling point:
806.69°C (rough estimate)
Density 
1.48±0.1 g/cm3 (20 ºC 760 Torr)
refractive index 
1.5280 (estimate)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly)
pka
12.77±0.70(Predicted)
form 
Solid
color 
White to Off-White
Merck 
14,9545
LogP
2.220 (est)
CAS DataBase Reference
17406-45-0
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Safety

Hazard Codes 
Xn
Risk Statements 
23/25-22
Safety Statements 
45-24/25-22
RIDADR 
1544
RTECS 
XW1050000
HS Code 
29329990
Hazardous Substances Data
17406-45-0(Hazardous Substances Data)
Toxicity
LD orally in rats: 900-1000 mg/kg (Wilson)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
T3636
Product name
Tomatine from Tomato
Purity
>80.0%(HPLC)
Packaging
100mg
Price
$222
Updated
2024/03/01
TRC
Product number
T538510
Product name
Tomatine(85%)
Packaging
5mg
Price
$150
Updated
2021/12/16
Usbiological
Product number
297817
Product name
Tomatine
Packaging
25mg
Price
$355
Updated
2021/12/16
Usbiological
Product number
301067
Product name
Tomatine
Packaging
10mg
Price
$490
Updated
2021/12/16
Biosynth Carbosynth
Product number
OT07656
Product name
Tomatine
Packaging
25mg
Price
$60
Updated
2021/12/16
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TOMATINE Chemical Properties,Usage,Production

Health Benifits

Tomatine (sometimes called tomatin or lycopersicin) is a glycoalkaloid, found in the stems and leaves of tomato plants, and in the fruits at much lower concentrations. It has fungicidal, antimicrobial, and insecticidal properties. Chemically pure tomatine is a white crystalline solid at standard temperature and pressure. Tomatine, as well as the closely related aglycon (or aglycone) derivative tomatidine have been shown to have multiple health benefits.
Tomatine is a steroid alkaloid that is tomatidine in which the hydroxy group at position 3 is linked to lycotetraose, a tetrasaccharide composed of two units of D-glucose, one unit of D-xylose, and one unit of D-galactose. It has a role as an immunological adjuvant, a phytotoxin and an antifungal agent. It is a steroid alkaloid, a tetrasaccharide derivative, an alkaloid antibiotic and a glycoside. It derives from a tomatidine.

Tomatine Toxin Symptoms

The possible risks of tomatine for humans have not been formally studied, so no NOAEL can be deduced. The toxicity of tomatine has only been studied on laboratory animals. The symptoms of acute tomatine poisoning in animals are similar to the symptoms of poisoning by solanine, a potato glycoalkaloid. These symptoms include vomiting, diarrhea, abdominal pain, drowsiness, confusion, weakness, and depression. Generally, tomatine is regarded to cause less toxic effect to mammals than other alkaloids such as solanine. The amount of tomatine absorbed by the human body as well as the possible metabolism is unknown. There is no evidence that consumption of tomatoes causes acute toxic or genotoxic effects.

Description

This glycosidic alkaloid has been obtained from the dried leaves of Lycopersicum pimpinelli/olium (Syn. Solanum racemigerum) and also occurs in L. esculentum; L. hirsutum; L. peruvianum; L. peruvianum var. chutatum and L. putatum. The alkaloid forms colourless needles from MeOH and has a somewhat indefinite melting point about 270°C. It is laevorotatory with [α]20D - 30° (pyridine) and on hydrolysis with H2S04 yields tomatidine, I mole of galactose, 2 moles of glucose and 1 mole of xylose. The tetrasaccharide unit is known as lycotetraose. Partial hydrolysis with acid yields a series of products depending upon which, and how many, of the sugar residues are split off from the molecule. Those which have been isolated are: tomatidine lycotriose I (galactose-glucose-glucose); tomatidine lycotriose II (galactose-glucose-xylose); tomatidine lycobiose (galactose-glucose) and tomatidine-galactose.

Chemical Properties

Faintly beige powder

Uses

Tomatine is used as an antiproliferatice agent used in the suppression of breast adenocarcinoma cells.

Uses

Precipitating agent for steroids.

Definition

ChEBI: A steroid alkaloid that is tomatidine in which the hydroxy group at position 3 is linked to lycotetraose, a tetrasaccharide composed of two units of D-glucose, one unit of D-xylose, and one unit of D-galac ose.

target

NF-kB | PI3K | Akt | ERK | MMP(e.g.TIMP) | AP-1 | ROS | Calcium Channel

Purification Methods

Tomatine is recrystallised from MeOH, EtOH, aqueous EtOH or dioxane/NH3. It is almost insoluble in pet ether, Et2O or H2O. [Reichstein Angew Chem 74 887 1962, Beilstein 27 III/IV 1954.]

References

Fontaine et al., Arch. Biochem., 18,467 (1948)
Kuhn, Low., Ber., 81, 552 (1948)
Kuhn, Low, Gauhe., ibid, 83,448 (1950)
Fontaine et al., Arch. Biochem., 27,461 (1950)
Fontaine et al., J. Amer. Chern. Soc., 73, 878 (1951)
Kuhn, Low, Trischmann., Angew. Chern., 68, 212 (1956)
Kuhn et al., Ber., 90, 203 (1957)

TOMATINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from TOMATINE manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
TOMATINE 17406-45-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-15
Hebei Mojin Biotechnology Co., Ltd
Product
TOMATINE 17406-45-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg/monnth
Release date
2023-08-10
Shanghai Standard Technology Co., Ltd.
Product
Tomatine 17406-45-0
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-03-18

17406-45-0, TOMATINERelated Search:

DI(PROPYLENE GLYCOL) BUTYL ETHER 2-heptyltetrahydrofuran 2-(OCTADECYLOXY)ETHANOL PROPYLENE GLYCOL BUTYL ETHER 12-AMINO-1-DODECANOL Dulcitol 1,12-OCTADECANEDIOL TOMATINE Dihydrocholesterol 2,6,8-TRIMETHYL-4-NONANOL PHYTANE 5α-Cholestane 2-(DODECYLOXY)ETHANOL Triethylene glycol TOMATIDINE 3-O-HEXADECYL-SN-GLYCEROL 1-BUTOXYETHOXY-2-PROPANOL 3-BUTOXY-PROPIONALDEHYDE DIETHYL ACETAL

  • TOMATIN
  • TOMATINE
  • a’’-tomatidine
  • alpha-tomatine
  • beta-d-galactopyranoside,(3beta,5alpha,22beta,25s)-spirosolan-3-ylo-beta-d-gl
  • tomatidine,glycoside
  • ucopyranosyl-(1-2)-o-(beta-d-xylopyranosyl-(1-3))-o-beta-d-glucopyranosyl-(1-4
  • LYCOPERISCIN
  • LYCOPERSICIN
  • LYOCPERSICIN
  • 22S,25S,5ALPHA-TOMATANIN-3BETA-OL 3-O-BETA-D-GLUCOPYRANOSYL-(1->2)-O-BETA-D-[3-O-BETA-D-XYLOPYRANOSYL GLUCOPYRANOSYL]-(1->4)-O-BETA-D-GALACTOPYRANOSIDE
  • .beta.-D-Galactopyranoside, (3.beta.,5.alpha.,22.beta.,25S)-spirosolan-3-yl O-.beta.-D-glucopyranosyl-(1?2)-O-.beta.-D-xylopyranosyl-(1?3)-O-.beta.-D-glucopyranosyl-(1?4)-
  • LYCOPERSICIN(TOMATINE)(RG)
  • TOMATINE(ST)
  • TOMATINE (SYN. LYCOPERSICIN)
  • Tomatine [for Cholesterol assay]
  • spirosolan-3-ylO-β-D-glucopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)]-O-β-D-glucopyranosyl-(1→4)-
  • β-D-Galactopyranoside,(3β,5α,22β,25S)-
  • [(22S,25S)-5α-Spirosolan-3β-yl]4-O-[2-O-(β-D-glucopyranosyl)-3-O-(β-D-xylopyranosyl)-β-D-glucopyranosyl]-β-D-galactopyranoside
  • LYCOPERSICIN(SEE TOMATINE)(RG)
  • TOMATINE(RG)
  • Tomatine ,95%
  • [for Cholesterol assay]
  • ToMatine&nbsp
  • ToMatine (85%)
  • a-Tomatine
  • b-D-galactopyranoside deriv
  • Tomatine hydrate
  • Tomatine from Tomato
  • LYCOPERISCIN tlc
  • NSC 234440
  • NSC 9223
  • β-D-Galactopyranoside, (3β,5α,22β,25S)-spirosolan-3-yl O-β-D-glucopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)]-O-β-D-glucopyranosyl-(1→4)-
  • omatine
  • LICOPERSICIN
  • Tomatie
  • (2S,3R,4S,5S,6R)-2-(((2S,3R,4S,5R,6R)-2-(((2R,3R,4R,5R,6R)-4,5-Dihydroxy-2-(hydroxymethyl)-6-(((2aS,4S,5'S,6aS,6bS,8aS,8bR,9S,10S,11aS,12aS,12bR)-5',6a,8a,9-tetramethyloctadecahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-piperidin]-4-yl)oxy)tetra
  • TOMATINE(P) 10mg
  • TOMATINE(P) 25mg
  • TOMATINE(P) 50mg
  • 17406-45-0
  • C50H83NO21
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