Definition Pharmaceutical Properties
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TOMATIDINE

Definition Pharmaceutical Properties
Product Name
TOMATIDINE
CAS No.
77-59-8
Chemical Name
TOMATIDINE
Synonyms
Tomatidin;omatidine;TOMATADINE;TOMATIDINE;NSC 226903;TOMATIDINE(RG);Spirosolan-3-ol;Tomatidine, >98%;5alpha-Tomatidan-3beta-ol;Spirosolan-3-ol,(3β,5α,22β,25S)-
CBNumber
CB3774922
Molecular Formula
C27H45NO2
Formula Weight
415.65
MOL File
77-59-8.mol
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TOMATIDINE Property

Melting point:
210.5℃
alpha 
D25 +8° (chloroform)
Boiling point:
534.2°C (rough estimate)
Density 
1.0048 (rough estimate)
refractive index 
1.6840 (estimate)
pka
15.14±0.70(Predicted)
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Safety

Risk Statements 
23/25
Safety Statements 
1-45
RIDADR 
1544
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
301066
Product name
Tomatidine
Packaging
10mg
Price
$490
Updated
2021/12/16
Biorbyt Ltd
Product number
orb594522
Product name
Tomatidine
Packaging
100 mg
Price
$778.6
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PXT0015864
Product name
TOMATIDINE
Purity
95.00%
Packaging
10MG
Price
$782.23
Updated
2021/12/16
ChemScene
Product number
CS-5821
Product name
Tomatidine
Purity
>98.0%
Packaging
25mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-5821
Product name
Tomatidine
Purity
>98.0%
Packaging
50mg
Price
$96
Updated
2021/12/16
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TOMATIDINE Chemical Properties,Usage,Production

Definition

Tomatidine is the aglycone derivative of tomatine. Tomatidine belongs to the chemical family known as Spirosolanes and Derivatives. These are steroidal alkaloids whose structure contains a spirosolane skeleton. Tomatine (the glycosylated form of tomatidine) is a mildly toxic glycoalkaloid or glycospirosolane found in the stems and leaves of tomato plants as well as in the fruit of unripened (green) tomatoes (up to 500 mg/kg).

Pharmaceutical Properties

Red, ripe tomatoes have somewhat reduced amounts of tomatine and tomatidine. Both tomatine and tomatidine possess antimicrobial, antifungal and antiviral properties. Tomatidine has been shown to exhibit anti-virulence activity against normal strains of Staphylococcus aureus as well as the ability to potentiate the effect of aminoglycoside antibiotics. Recent studies have shown that tomatidine stimulates mTORC1 signaling and anabolism, leading to accumulation of protein and mitochondria, and ultimately, cell growth. Furthermore, in mice, tomatidine has been shown to increase skeletal muscle mTORC1 signaling, reduce skeletal muscle atrophy, enhance recovery from skeletal muscle atrophy, stimulate skeletal muscle hypertrophy, and increase strength and exercise capacity. Tomatidine has also been shown to significantly inhibit cholesterol ester accumulation induced by acetylated LDL in human monocyte-derived macrophages in a dose-dependent manner. Tomatidine also inhibits cholesterol ester formation in Chinese hamster ovary cells overexpressing acyl-CoA:cholesterol acyl-transferase (ACAT)-1 or ACAT-2, suggesting that tomatidine suppresses both ACAT-1 and ACAT-2 activities. The oral administration of tomatidine to apoE-deficient mice significantly reduces levels of serum cholesterol, LDL-cholesterol, and the size of atherosclerotic lesions.

Chemical Properties

Crystals. Decomposes at 275–280C.

Definition

ChEBI: A 3beta-hydroxy steroid resulting from the substitution of the 3beta-hydrogen of tomatidane by a hydroxy group.

Purification Methods

Tomatidine forms plates from EtOAc. It is also purified by dissolving 80mg in *C6H6 and applying to an Al2O3 column (3.0g) and eluting with *C6H6, evaporating and recrystallising the residue three times from EtOAc. The hydrochloride has m 265-270o from EtOH and [] D 25 -5o (MeOH). [IR: Uhle J Am Chem Soc 83 1460 1961, Kessar et al. Tetrahedron 27 2869 1971, Schreiber & Adams Experientia 17 13 1961, Beilstein 27 III/IV 1950.]

TOMATIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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TOMATIDINE Suppliers

Shanghai Boyle Chemical Co., Ltd.
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2926
Advantage
55
BOC Sciences
Email
info@bocsci.com
Country
United States
ProdList
21113
Advantage
65
Chengdu Biopurify Phytochemicals Ltd.
Tel
028-82633397-
Fax
+86-28-82633165
Email
daisy@biopurify.cn
Country
China
ProdList
2040
Advantage
60
Shanghai Winherb Medical Technology Co., Ltd.
Tel
136-81877033- ;
Fax
QQ:190129269
Email
winherb@126.com;2702713455@qq.com
Country
China
ProdList
1010
Advantage
58
MedChemexpress LLC
Tel
609-228-6898
Fax
609-228-5909
Email
sales@medchemexpress.com
Country
United States
ProdList
4788
Advantage
58
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
4041
Advantage
66
Shanghai Yaocheng Pharmaceutical Technology Co., Ltd.
Email
zhy@yaohuikj.com
Country
China
ProdList
270
Advantage
55
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366-
Email
sales@chem-strong.com
Country
China
ProdList
26481
Advantage
56
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785-
Fax
051085625359
Email
sales@reading-chemicals.com;
Country
China
ProdList
15200
Advantage
58
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8151
Advantage
55
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View Lastest Price from TOMATIDINE manufacturers

Hebei Crovell Biotech Co Ltd
Product
Tomatidine 77-59-8
Price
US $10.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2021-07-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
tomatidine 77-59-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26
Shanghai Standard Technology Co., Ltd.
Product
Tomatidine 77-59-8
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-03-23

77-59-8, TOMATIDINERelated Search:


  • SPIRPSOLAN-3-OL-(3beta,5alpha,22beta,25delta)
  • 22S,25S,5ALPHA-TOMATANIN-3BETA-OL
  • SPIROSOLAN-3-OL-(3BETA,5ALPHA,22BETA,25ALPHA)
  • SPIRPSOLAN-3-OL-(3BETA,5ALPHA,22BETA,25ALPHA)
  • TOMATIDINE
  • 5alpha-Tomatidan-3beta-ol
  • Spirosolan-3-ol
  • Spirosolan-3-ol, (3beta,5alpha,22beta,25S)-
  • Tomatidin
  • TOMATADINE
  • Spirosolan-3-ol,(3β,5α,22β,25S)-
  • TOMATIDINE(RG)
  • Tomatidine, >98%
  • NSC 226903
  • Tomatidine, 98%, from Lycopersicon esculentum Mill.
  • omatidine
  • 77-59-8
  • C27H45NO2
  • Alkaloids