TOMATIDINE

ChemicalBook > CAS DataBase List > TOMATIDINE

Definition Pharmaceutical Properties

Product Name: TOMATIDINE
CAS No.: 77-59-8
Chemical Name: TOMATIDINE
Synonyms: Tomatidin;omatidine;TOMATADINE;TOMATIDINE;NSC 226903;TOMATIDINE(RG);Spirosolan-3-ol;Tomatidine, >98%;5alpha-Tomatidan-3beta-ol;Spirosolan-3-ol,(3β,5α,22β,25S)-
CBNumber: CB3774922
Molecular Formula: C27H45NO2
Formula Weight: 415.65
MOL File: 77-59-8.mol

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TOMATIDINE Property

Melting point:: 210.5℃
alpha: D25 +8° (chloroform)
Boiling point:: 534.2°C (rough estimate)
Density: 1.0048 (rough estimate)
refractive index: 1.6840 (estimate)
storage temp.: Store at -20°C
solubility: DMSO : 2.86 mg/mL (6.88 mM);Water : < 0.1 mg/mL (insoluble)
pka: 15.14±0.70(Predicted)
form: Solid
color: White to off-white
LogP: 6.150 (est)

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Safety

Risk Statements: 23/25
Safety Statements: 1-45
RIDADR: 1544

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological

Product number: 301066
Product name: Tomatidine
Packaging: 10mg
Price: $490
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb594522
Product name: Tomatidine
Packaging: 100mg
Price: $778.6
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PXT0015864
Product name: TOMATIDINE
Purity: 95.00%
Packaging: 10MG
Price: $782.23
Updated: 2021/12/16

ChemScene

Product number: CS-5821
Product name: Tomatidine
Purity: >98.0%
Packaging: 25mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-5821
Product name: Tomatidine
Purity: >98.0%
Packaging: 50mg
Price: $96
Updated: 2021/12/16

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TOMATIDINE Chemical Properties,Usage,Production

Definition

Tomatidine is the aglycone derivative of tomatine. Tomatidine belongs to the chemical family known as Spirosolanes and Derivatives. These are steroidal alkaloids whose structure contains a spirosolane skeleton. Tomatine (the glycosylated form of tomatidine) is a mildly toxic glycoalkaloid or glycospirosolane found in the stems and leaves of tomato plants as well as in the fruit of unripened (green) tomatoes (up to 500 mg/kg).

Pharmaceutical Properties

Red, ripe tomatoes have somewhat reduced amounts of tomatine and tomatidine. Both tomatine and tomatidine possess antimicrobial, antifungal and antiviral properties. Tomatidine has been shown to exhibit anti-virulence activity against normal strains of Staphylococcus aureus as well as the ability to potentiate the effect of aminoglycoside antibiotics. Recent studies have shown that tomatidine stimulates mTORC1 signaling and anabolism, leading to accumulation of protein and mitochondria, and ultimately, cell growth. Furthermore, in mice, tomatidine has been shown to increase skeletal muscle mTORC1 signaling, reduce skeletal muscle atrophy, enhance recovery from skeletal muscle atrophy, stimulate skeletal muscle hypertrophy, and increase strength and exercise capacity. Tomatidine has also been shown to significantly inhibit cholesterol ester accumulation induced by acetylated LDL in human monocyte-derived macrophages in a dose-dependent manner. Tomatidine also inhibits cholesterol ester formation in Chinese hamster ovary cells overexpressing acyl-CoA:cholesterol acyl-transferase (ACAT)-1 or ACAT-2, suggesting that tomatidine suppresses both ACAT-1 and ACAT-2 activities. The oral administration of tomatidine to apoE-deficient mice significantly reduces levels of serum cholesterol, LDL-cholesterol, and the size of atherosclerotic lesions.

Chemical Properties

Crystals. Decomposes at 275–280C.

Definition

ChEBI: A 3beta-hydroxy steroid resulting from the substitution of the 3beta-hydrogen of tomatidane by a hydroxy group.

Purification Methods

Tomatidine forms plates from EtOAc. It is also purified by dissolving 80mg in *C6H6 and applying to an Al2O3 column (3.0g) and eluting with *C6H6, evaporating and recrystallising the residue three times from EtOAc. The hydrochloride has m 265-270o from EtOH and [] D 25 -5o (MeOH). [IR: Uhle J Am Chem Soc 83 1460 1961, Kessar et al. Tetrahedron 27 2869 1971, Schreiber & Adams Experientia 17 13 1961, Beilstein 27 III/IV 1950.]

TOMATIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from TOMATIDINE manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: Tomatidine 77-59-8
Price: US $10.50/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-20

Shanghai Standard Technology Co., Ltd.

Product: Tomatidine 77-59-8
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-03-23

Zhuozhou Wenxi import and Export Co., Ltd

Product: tomatidine 77-59-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

77-59-8, TOMATIDINERelated Search:

veratramine 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one VERATRINE Lycopene CONIINE, D/L-(RG) TOMATIDINE a’’-tomatidin Cyclopentamine 2-CYCLOPENTYL-ETHYLAMINE Dihydrocholesterol 2-PIPERIDINOL 5α-Cholestane 3-PIPERIDIN-2-YL-PROPAN-1-OL 2-(1-methylethyl)piperidine 2-AMINONONADECANE Tomatidine hydrochloride TOMATIDINE HCL(SH) N-propylisononylamine

SPIRPSOLAN-3-OL-(3beta,5alpha,22beta,25delta)

22S,25S,5ALPHA-TOMATANIN-3BETA-OL

SPIROSOLAN-3-OL-(3BETA,5ALPHA,22BETA,25ALPHA)

SPIRPSOLAN-3-OL-(3BETA,5ALPHA,22BETA,25ALPHA)

TOMATIDINE

5alpha-Tomatidan-3beta-ol

Spirosolan-3-ol

Spirosolan-3-ol, (3beta,5alpha,22beta,25S)-

Tomatidin

TOMATADINE

Spirosolan-3-ol,(3β,5α,22β,25S)-

TOMATIDINE(RG)

Tomatidine, >98%

NSC 226903

Tomatidine, 98%, from Lycopersicon esculentum Mill.

omatidine

77-59-8

C27H45NO2

Alkaloids