Tomatidine hydrochloride
- Product Name
- Tomatidine hydrochloride
- CAS No.
- 6192-62-7
- Chemical Name
- Tomatidine hydrochloride
- Synonyms
- TOMATIDINE HCL;TOMATIDINE HCL(RG);TOMATIDINE HYDROCHLORIDE;ToMatidin Hydrochloride, >85%;Tomatidine Hydrochloride, >5alpha-Tomatidan-3beta-ol HCl;Tomatidine, Hydrochloride, >85%;5α-Tomatidan-3β-ol hydrochloride;SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL;3β-Hydroxy-5α-tomatidane hydrochloride
- CBNumber
- CB6774105
- Molecular Formula
- C27H46ClNO2
- Formula Weight
- 452.11
- MOL File
- 6192-62-7.mol
Tomatidine hydrochloride Property
- Melting point:
- 281-284°C (dec.)
- storage temp.
- 2-8°C
- solubility
- Methanol (Slightly)
- form
- Off-white solid
- color
- White to Off-White
- BRN
- 3920740
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T2909
- Product name
- Tomatidine hydrochloride
- Purity
- ≥85%
- Packaging
- 25mg
- Price
- $75.2
- Updated
- 2024/03/01
- Product number
- PHL80003
- Product name
- Tomatidine hydrochloride
- Purity
- phyproof? Reference Substance
- Packaging
- 20MG
- Price
- $328
- Updated
- 2023/01/07
- Product number
- 614350
- Product name
- Tomatidine, HCl
- Packaging
- 25mg
- Price
- $96.4
- Updated
- 2023/01/07
- Product number
- 16938
- Product name
- Tomatidine (hydrochloride)
- Purity
- ≥90%
- Packaging
- 10mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 16938
- Product name
- Tomatidine (hydrochloride)
- Purity
- ≥90%
- Packaging
- 25mg
- Price
- $66
- Updated
- 2024/03/01
Tomatidine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
Tomatidine hydrochloride is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine.Tomatidine protects against muscle atrophy and boosting muscle growth (see also Ursolic Acid).
Biological Activity
Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes. It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM. It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 μg/ml, respectively). It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice. Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway.
Mode of action
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans.
Tomatidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Tomatidine hydrochloride Suppliers
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View Lastest Price from Tomatidine hydrochloride manufacturers
- Product
- Tomatidine hydrochloride 6192-62-7
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-03-26
- Product
- Tomatidine hydrochloride 6192-62-7
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-03-26
- Product
- TOMATIDINE HYDROCHLORIDE 6192-62-7
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,50kg
- Release date
- 2020-01-18