ChemicalBook > CAS DataBase List > Tomatidine hydrochloride

Tomatidine hydrochloride

Product Name
Tomatidine hydrochloride
CAS No.
6192-62-7
Chemical Name
Tomatidine hydrochloride
Synonyms
TOMATIDINE HCL;TOMATIDINE HCL(RG);TOMATIDINE HYDROCHLORIDE;Tomatidine hydrochloride-RM;ToMatidin Hydrochloride, >85%;Tomatidine Hydrochloride, >5alpha-Tomatidan-3beta-ol HCl;Tomatidine, Hydrochloride, >85%;5α-Tomatidan-3β-ol hydrochloride;SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL
CBNumber
CB6774105
Molecular Formula
C27H46ClNO2
Formula Weight
452.11
MOL File
6192-62-7.mol
More
Less

Tomatidine hydrochloride Property

Melting point:
281-284°C (dec.)
storage temp. 
2-8°C
solubility 
Methanol (Slightly)
form 
Off-white solid
color 
White to Off-White
BRN 
3920740
More
Less

Safety

Safety Statements 
22-24/25
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T2909
Product name
Tomatidine hydrochloride
Purity
≥85%
Packaging
25mg
Price
$75.2
Updated
2024/03/01
Sigma-Aldrich
Product number
PHL80003
Product name
Tomatidine hydrochloride
Purity
phyproof? Reference Substance
Packaging
20MG
Price
$328
Updated
2023/01/07
Sigma-Aldrich
Product number
614350
Product name
Tomatidine, HCl
Packaging
25mg
Price
$96.4
Updated
2023/01/07
Cayman Chemical
Product number
16938
Product name
Tomatidine (hydrochloride)
Purity
≥90%
Packaging
10mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
16938
Product name
Tomatidine (hydrochloride)
Purity
≥90%
Packaging
25mg
Price
$66
Updated
2024/03/01
More
Less

Tomatidine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Tomatidine hydrochloride is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine.Tomatidine protects against muscle atrophy and boosting muscle growth (see also Ursolic Acid).

Biological Activity

Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes. It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM. It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 μg/ml, respectively). It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice. Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway.

Mode of action

Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans.

Tomatidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Tomatidine hydrochloride Suppliers

Canada 1 China 88 Germany 1 India 1 Switzerland 1 United Kingdom 3 United States 15 Global 110
Nanning Saifir Biotechnology Co., Ltd.
Tel
18877121284
Email
1309367106@qq.com
Country
China
ProdList
261
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Chengdu Herbpurify Co.Ltd.
Tel
18302802153 18981717076
Fax
086-28-85377358
Email
2355253619@qq.com
Country
China
ProdList
1104
Advantage
58
DONGSHENG CHIRAL PHARMA
Tel
18051538752
Email
3755454181@qq.com
Country
China
ProdList
434
Advantage
55
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7887
Advantage
56
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
7057
Advantage
55
Hangzhou Dingyan Chem Co., LTD
Tel
0571-87157530-8007 13868066926
Fax
0571-87156470
Email
sales@dingyanchem.com
Country
China
ProdList
2190
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
Shanghai ChengShao Biological Technology Co., Ltd.
Tel
021-61847300 13341622919
Fax
021-61847300
Email
shcss01@163.com
Country
China
ProdList
4808
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8012
Advantage
62
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Shanghai Uteam Biotechnology Co., Ltd.
Tel
021-36031160 13311776681
Email
3338195766@QQ.com
Country
China
ProdList
5175
Advantage
55
Shanghai Biological Technology Development Co., Ltd.
Tel
021-69955236-807 13918189704
Fax
021-65211385
Email
chinaruji@chinaruji.com
Country
China
ProdList
5176
Advantage
55
Chengdu Push Bio-Technology Co., Ltd.
Tel
028-85370565-229 18080489829
Email
3004654993@qq.com
Country
China
ProdList
8861
Advantage
60
Chengdu Alfa Biotechnology Co.,Ltd.
Tel
028-85142057, 18030712385
Fax
028-85142057 QQ:3591697873
Email
sales@alfabiotech.com
Country
China
ProdList
1925
Advantage
58
Chengdu Greenpure Biopharma CO.,Ltd
Tel
028-88203606; 18283602253
Email
jancyzheng@gcgreenpure.com
Country
China
ProdList
1589
Advantage
58
Shanghai Standard Technology Co.,Ltd.
Tel
021-021-57127007-6622-6622 17621252073
Fax
+86 (21) 5132-0077
Email
luzh@nature-standard.com
Country
China
ProdList
3021
Advantage
58
Shanghai Innovative Reseach Center Of Traditional
Tel
86-21-50801717-301
Fax
86-21-50800509
Email
wangjh@sirc-tcm.sh.cn
Country
China
ProdList
2070
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52693
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Nanjing Digger Medical Technology Co. Ltd.
Tel
025-025-51191215 18013836722
Fax
025-51191215
Email
2399235533@qq.com
Country
China
ProdList
4933
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
Aktin Chemicals, Inc.
Tel
028-85159085
Fax
86-28-85159085 Ex:604
Email
info@aktinchem.com
Country
CHINA
ProdList
1025
Advantage
58
Wuhan ChemNorm Biotech Co.,Ltd.
Tel
+86-27-8439 4403 18971486879
Fax
+86-27-8439 4403
Email
sales@chemnorm.com
Country
CHINA
ProdList
2935
Advantage
58
Zhejiang Lianshuo Biotechnology Co., Ltd.
Tel
18616526224
Email
lianshuo@vip.126.com
Country
China
ProdList
9607
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Shanghai Standard Technology Co., Ltd.
Tel
18502101150
Fax
+86-21-57127007-6606
Email
ft-sales@nature-standard.com
Country
CHINA
ProdList
1923
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai jingkang bioengineering co., ltd.
Tel
021-54721350 13524668266
Fax
021-5
Email
2881505714@qq.com
Country
China
ProdList
7872
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29811
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-87569262 +86-15319487004
Fax
029-88380327
Email
1015@dideu.com
Country
China
ProdList
3209
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
wulan@absin.cn
Country
China
ProdList
24731
Advantage
58
Shanghai Fusheng Industrial Co., LTD
Tel
021-52961053 13524666654
Email
3004902811@qq.com
Country
China
ProdList
9724
Advantage
58
Wuxi Helen Biotechnology Co., Ltd.,
Tel
0510-85629785 18013409632
Fax
0510-85625359
Email
sales@reading-chemicals.com
Country
China
ProdList
14081
Advantage
58
Wuhan ChemNorm co., LTD.
Tel
18971486879
Email
279414929@qq.com
Country
CHINA
ProdList
2925
Advantage
58
ChengDu YiRui Bio-Technology CO., LTD
Tel
182-24028459 18224018291
Fax
QQ137193152
Email
3004072879@qq.com
Country
China
ProdList
1195
Advantage
58
Shanghai Hewu Biotechnology Co., LTD
Tel
021-57886085 17317861055
Email
shhebio@126.com
Country
CHINA
ProdList
7974
Advantage
58
Aktin Chemicals, Inc.
Tel
028-85159085
Email
info@aktinchem.com
Country
China
ProdList
1769
Advantage
58
Guizhou Dida Technology Co., Ltd
Tel
0851-8475-2296 18096062265
Fax
0851-84752205
Email
646585516@qq.com
Country
China
ProdList
2778
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44458
Advantage
58
Foshan Treasure Biotechnology Co., Ltd
Tel
0757-85921206 18520245316
Email
2329783215@qq.com
Country
China
ProdList
12661
Advantage
58
More
Less

View Lastest Price from Tomatidine hydrochloride manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Tomatidine hydrochloride 6192-62-7
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-03-26
Shanghai Standard Technology Co., Ltd.
Product
Tomatidine hydrochloride 6192-62-7
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-03-26
Career Henan Chemical Co
Product
TOMATIDINE HYDROCHLORIDE 6192-62-7
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,50kg
Release date
2020-01-18

6192-62-7, Tomatidine hydrochlorideRelated Search:

Xanthiside Lycopene Apo-12'-lycopenal L-Hyoscyamine menisdaurin daurisoline TOMATINE TOMATIDINE OCTADECYLAMINE HYDROCHLORIDE 2-Propylpiperidine hydrochloride Cyclopentamine 2-PIPERIDINOL Dihydrocholesterol 2-AMINONONADECANE Tomatidine hydrochloride 3-PIPERIDIN-2-YL-PROPAN-1-OL cyclopentamine hydrochloride DIISOBUTYLAMINE HYDROCHLORIDE

  • 3BETA-HYDROXY-5ALPHA-TOMATIDANE HYDROCHLORIDE
  • 5ALPHA-TOMATIDAN-3BETA-OL HYDROCHLORIDE
  • TOMATIDINE HCL
  • TOMATIDINE HYDROCHLORIDE
  • SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL
  • (3beta,5alpha,22beta,25S)-Spirosolan-3-ol hydrochloride
  • TOMATIDINE HCL(RG)
  • Tomatidine, Hydrochloride, >85%
  • ToMatidin Hydrochloride, >85%
  • 3β-Hydroxy-5α-tomatidane hydrochloride, 5α-Tomatidan-3β-ol hydrochloride
  • (3β,5α,22β,25S)-Spirosolan-3-ol Hydrochloride
  • (3beta,5alpha,22beta,25S)-Spirosolan-3-ol hydrochloride (1:1)
  • 3β-Hydroxy-5α-tomatidane hydrochloride
  • 5α-Tomatidan-3β-ol hydrochloride
  • Tomatidine, HCl - CAS 6192-62-7 - Calbiochem
  • Tomatidine Hydrochloride, &gt
  • 5alpha-Tomatidan-3beta-ol HCl
  • Tomatidine hydrochloride-RM
  • 6192-62-7
  • C27H46ClNO2
  • C27H45NO2HCl
  • Lipid signaling
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids