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Cyclopentamine

Product Name
Cyclopentamine
CAS No.
102-45-4
Chemical Name
Cyclopentamine
Synonyms
Clopane;Cxyklosal;Cyclonarol;Cyclopentamin;Cyclopentadrin;Cyclopentamine;N,α-Dimethylcyclopentaneethanamine;1-cyclopentyl-N-methylpropan-2-amine;1-cyclopentyl-N-methyl-propan-2-amine;Cyclopentaneethanamine, N,α-dimethyl-
CBNumber
CB31117072
Molecular Formula
C9H19N
Formula Weight
141.25
MOL File
102-45-4.mol
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Cyclopentamine Property

Boiling point:
171.05°C
Density 
0.7566 (rough estimate)
refractive index 
1.4920 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
pKa 11.47 (Uncertain)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
CHM0146893
Product name
CYCLOPENTAMINE
Purity
95.00%
Packaging
5MG
Price
$502.46
Updated
2021/12/16
Crysdot
Product number
CD13027970
Product name
1-Cyclopentyl-N-methylpropan-2-amine
Purity
97%
Packaging
1g
Price
$505
Updated
2021/12/16
Ambeed
Product number
A112301
Product name
1-Cyclopentyl-N-methylpropan-2-amine
Purity
97%
Packaging
50mg
Price
$57
Updated
2021/12/16
Chemenu
Product number
CM202757
Product name
1-cyclopentyl-N-methylpropan-2-amine
Purity
97%
Packaging
1g
Price
$477
Updated
2021/12/16
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Cyclopentamine Chemical Properties,Usage,Production

Originator

Clopane,Lilly,US,1951

Definition

ChEBI: Cyclopentamine is a secondary amino compound.

Manufacturing Process

A mixture of 126 g (1.5 mols) of cyclopentanone, 128 g (1.5 mols) cyanoacetic acid, 31 g (0.5 mol) of ammonium acetate and 200 cc of dry benzene is heated under a refluxing condenser and a water trap. The mixture is refluxed for about 12 hours after which time no more water collects in the trap, and the formation of cyclopentylideneacetonitrile is complete. The reaction mixture comprising a mixture of cyclopentylideneacetonitrile and cyclopentylideneacetic acid is washed with about one liter of 2% hydrochloric acid and the benzene layer is separated and the mixture is distilled to cause decarboxylation of the cyclopentylideneacetic acid present. The distillate comprising cyclopentylideneacetonitrile which boils at 172° to 175°C is purified by distillation.
A mixture of 53.5 g (0.5 mol) of cyclopentylideneacetonitrile dissolved in 50 cc of absolute ethanol and 0.5 g of a palladium-carbon catalyst is hydrogenated with hydrogen at a pressure of about 40 lb for about 3 hours. An additional amount of 0.8 g of palladium-carbon catalyst is then added and the hydrogenation continued for about 4 hours during which time the reduction is substantially completed and the cyclopentylideneacetonitrile is converted to cyclopentylacetonitrile. The reaction mixture is filtered to remove the catalyst and the alcohol is evaporated in vacuo.
The residue comprising chiefly cyclopentylacetonitrile is washed with dilute hydrochloric acid to remove any amine which may have been formed during the hydrogenation process, and the organic residue comprising cyclopentylacetonitrile is dissolved in ether, the ether solution dried over anhydrous magnesium sulfate and distilled. The cyclopentylacetonitrile boils at 185° to 187°C and has a refractive index of nD25 = 1.4456.
To an ethereal solution of methyl magnesium iodide prepared from 26.7 g (1.1 mols) of magnesium and 160 g (1.13 mols) of methyl iodide in 200 cc of dry ether, is added a solution of 79 g (0.72 mol) of cyclopentylacetonitrile in 100 cc of dry ether. The reaction mixture is refluxed for 4 hours. The reaction mixture is then decomposed with ice in the usual way, and the ether layer containing the cyclopentylacetone is separated, is dried over anhydrous magnesium sulfate and the ether removed by evaporation. The residue comprising cyclopentylacetone is purified by distillation in vacuo. The cyclopentylacetone boils at 82° to 84°C at about 32 mm pressure.
A mixture of 75 g (0.6 mol) of cyclopentylacetone, 75 g (2.4 mols) of methylamine, and 10 g of Raney nickel catalyst is placed in a high pressure bomb previously cooled to a temperature below -6°C, and hydrogen is admitted under an initial pressure of about 2,000 psi. The bomb is then heated to about 135° to 150°C for about 2 hours, during which time reductive amination takes place and 1-cyclopentyl-2-methylaminopropane is produced. During the period of heating the reaction mixture is agitated by rocking the bomb. The bomb is then cooled and opened thus permitting the escape of hydrogen and most of the excess methylamine. The reaction mixture is filtered to remove the nickel catalyst and the filtrate comprising 1-cyclopentyl- 2-methylaminopropane is purified by distillation under reduced pressure. 1- Cyclopentyl-2-methylaminopropane boils at 83° to 86°C at about 30 mm pressure.
1-Cyclopentyl-2-methylaminopropane thus produced is a colorless liquid of slightly ammoniacal odor. It has a refractive of nD25 = 1.4500. Analysis showed the presence of 9.79% N as compared with a calculated value of 9.99% N.
141 g (1 mol) of 1-cyclopentyl-2-methylaminopropane are dissolved in 500 cc of dry ether, and dry hydrogen chloride is passed into the solution until the weight of the mixture and container has increased by 36 g. During the addition of the hydrogen chloride, the hydrochloric acid addition salt of 1- cyclopentyl-2-methylaminopropane precipitates as a white powder. The salt is filtered off and washed with dry ether. 1-Cyclopentyl-2-methylaminopropane hydrochloride thus prepared melts at about 113° to 115°C. The yield is practically quantitative.

brand name

Clopane Hydrochloride (Lilly).

Therapeutic Function

Vasoconstrictor

Cyclopentamine Preparation Products And Raw materials

Raw materials

Preparation Products

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Cyclopentamine Suppliers

Chembon Pharmaceutical Co., Ltd.
Tel
028-84252981
Fax
+86-28-84252965
Email
sales@chembon.com.cn
Country
China
ProdList
776
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64
Aikon International Limited
Tel
025-66113011 18112977050
Fax
(5)02557626880
Email
cb6@aikonchem.com
Country
China
ProdList
15495
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
0551-65418671
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34572
Advantage
58
Shanxi Xuanran Import and Export Trade Co., Ltd.
Tel
+8617735180244
Email
mike_yan@xuanranglobal.com
Country
CHINA
ProdList
4022
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 15093356674;
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30256
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-61398051 +8613650506873
Email
sales@chemdad.com
Country
China
ProdList
39916
Advantage
58
Shanghai Haohong Scientific Co., Ltd.
Tel
400-400-8210725
Email
malulu@leyan.com
Country
China
ProdList
40041
Advantage
58
Shaanxi Xihua Chemical Industry Co., Ltd
Tel
17691182729 15529505138
Email
1021@dideu.com
Country
China
ProdList
10011
Advantage
58
Chembon Pharmaceutical Co., Ltd.
Tel
+86-28-8425-2981
Fax
+86-28-8425-2965
Country
CHINA
ProdList
724
Advantage
55
Shanghai Acmec Biochemical Technology Co., Ltd.
Tel
+undefined18621343501
Email
product@acmec-e.com
Country
China
ProdList
33349
Advantage
58

102-45-4, CyclopentamineRelated Search:


  • Cyclopentamin
  • N,α-Dimethylcyclopentaneethanamine
  • (2-cyclopentyl-1-methyl-ethyl)-methyl-amine
  • 1-cyclopentyl-N-methyl-propan-2-amine
  • 1-cyclopentyl-N-methylpropan-2-amine
  • (1-Cyclopentylpropan-2-yl)(methyl)amine
  • Cyclopentamine
  • Cxyklosal
  • Clopane
  • Cyclonarol
  • Cyclopentadrin
  • Cyclopentaneethanamine, N,α-dimethyl-
  • 102-45-4