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alpha-Solanine

Product Name
alpha-Solanine
CAS No.
20562-02-1
Chemical Name
alpha-Solanine
Synonyms
solanine;SOLATUNIN;α-Solanin;SOLATUNINE;a-Solanine;α-Solanine;ALPHA-SOLANIN;ALPHA-SOLANINE;α-Solanine ,99%;SOLANINE, ALPHA
CBNumber
CB9696314
Molecular Formula
C45H73NO15
Formula Weight
868.07
MOL File
20562-02-1.mol
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alpha-Solanine Property

Melting point:
285℃ (dec.)
Boiling point:
780.78°C (rough estimate)
Density 
1.40±0.1 g/cm3 (20 ºC 760 Torr)
refractive index 
1.5280 (estimate)
storage temp. 
−20°C
solubility 
Methanol (Slightly, Heated), Pyridine (Slightly, Sonicated), Water (Slightly, Heated)
form 
Solid
pka
6.66(at 15℃)
color 
White to Off-White
Water Solubility 
26.04mg/L(15 ºC)
Merck 
13,8779
BRN 
77607
InChIKey
ZGVSETXHNHBTRK-MUEWWJAYNA-N
LogP
5.670 (est)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
1-25-45-24/25
RIDADR 
1544
WGK Germany 
3
RTECS 
WF0250000
10
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29399990
Hazardous Substances Data
20562-02-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S3757
Product name
α-Solanine
Purity
from potato sprouts, ≥95%
Packaging
5mg
Price
$152
Updated
2024/03/01
Sigma-Aldrich
Product number
S3757
Product name
α-Solanine
Purity
from potato sprouts, ≥95%
Packaging
10mg
Price
$227
Updated
2024/03/01
Sigma-Aldrich
Product number
S3757
Product name
α-Solanine
Purity
from potato sprouts, ≥95%
Packaging
50mg
Price
$766
Updated
2024/03/01
Sigma-Aldrich
Product number
PHL80074
Product name
α-Solanine
Purity
phyproof Reference Substance
Packaging
10mg
Price
$356
Updated
2024/03/01
TRC
Product number
S676503
Product name
α-Solanine
Packaging
2.5mg
Price
$200
Updated
2021/12/16
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alpha-Solanine Chemical Properties,Usage,Production

Description

This steroidal alkaloid is present in several Solanum species including S. nigrum, S. Iycopersicum (tomato) and S. tuberosum (potato). The base crystallizes in slender needles and shrinks markedly at 235°C. It has [α]20D - 59.45° (pyridine) or - 42.16° (dilute HCl) and is readily soluble in hot EtOH, sparingly so in H20 and virtually insoluble in CHCl 3 or Et2 0. The salts are mostly amorphous although a crystalline hydrochloride has been prepared with m.p. 212°C (dec.). It is not affected by alkalies but mineral acids hydrolyze it to solanidine (q.v.) and one mole each of dextrose, galactose and rhamnose.
Pharmacologically, the alkaloid is a protoplasmic poison and a powerful haemolytic. Poisoning by potatoes sometimes occurs although the results are not usually fatal. The symptoms are nausea, headache, emesis and gastritis. With large doses parenchymatous nephritis and haemoglobinuria occurs with, at times, paralysis of the central nervous system and cardiac arrest. The alkaloid also possesses local irritant properties.

Chemical Properties

White solid

Uses

α-Solanine is produced as a by product in the synthesis of α-Chaconine. α-Chaconine is a glycoalkaloid displaying nerve toxin activity. Potential antifungal activity.

Definition

ChEBI: A glycoalkaloid poison found in species of the nightshade family (Solanaceae), such as the potato (Solanum tuberosum). It is a trisccharide derivative of solanidine [(22beta)-solanid-5-en-3beta-ol].

benefits

It has been revealed that α-solanine possesses potential chemotherapeutic action against cancers in several organs, including lung, breast, esophagus, prostate, and liver, as well as acute lymphocytic leukemia. α-solanine also has potential anti-inflammatory properties[1].

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Hazard

A poison.

Side effects

A small amount of α-solanine can cause common symptoms such as dizziness, nausea, abdominal pain, vomiting, and diarrhea. Excessive consumption of α-solanine can lead to convulsions, coma, and even death. Animal studies have shown that α-solanine can damage the reproductive system[1].

Purification Methods

Recrystallise -solanine from EtOH, 85% aqueous EtOH, MeOH or aqueous MeOH as dihydrate m 276-278o. It solubility in H2O is 25mg/L and 5% in pyridine, but it is very soluble in Et2O and CHCl3. The hydrochloride is gummy or amorphous but has been crystallised (m ~212o dec). It has insecticidal properties. [Kuhn et al. Chem Ber 88 1492 1955, Beilstein 21 III/IV 1402.]

References

Desfosses.,lahresb., 2, 114 (1820)
Firbas., Monatsh., 10, 541 (1889)
Cazeneuve, Breteau., Compt. rend., 128,887 (1899)
Davis., Pharm. I., 15, 160 (1902)
Wittman., Monatsh., 26,445 (1905)
Colombano., Gazzetta, 38, 19 (1908)
Zemplen, Gerecs., Ber., 61,2294 (1928)
Schopf, Herrmann., ibid, 66, 298 (1933)
Oddo, Caronna., ibid, 67,446 (1934)

References

[1] Zhilong Chen. “α-Solanine Causes Cellular Dysfunction of Human Trophoblast Cells via Apoptosis and Autophagy.” Toxins (2021).

alpha-Solanine Preparation Products And Raw materials

Raw materials

Preparation Products

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alpha-Solanine Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
ProdList
96815
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Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
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Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7893
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Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15185
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Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9590
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58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
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Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
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China
ProdList
51471
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ALB Technology Limited
Tel
702-983-3769
Fax
702-983-3769
Email
sales@albtechnology.com
Country
United States
ProdList
2993
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Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
7059
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55
Biyu Biotechnology (Shanghai) Co., ltd
Tel
021-26018599
Country
China
ProdList
270
Advantage
56
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View Lastest Price from alpha-Solanine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
α-Solanine 20562-02-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-09
Dideu Industries Group Limited
Product
ALPHA-SOLANINE 20562-02-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-23

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