AJMALINE
- Product Name
- AJMALINE
- CAS No.
- 4360-12-7
- Chemical Name
- AJMALINE
- Synonyms
- Ritmos;Ajmalin;Ignazin;Takycor;Aritmina;AJMALINE;Rytmalin;Siddiqui;Tajmalin;Cartagine
- CBNumber
- CB6235145
- Molecular Formula
- C20H26N2O2
- Formula Weight
- 326.43
- MOL File
- 4360-12-7.mol
AJMALINE Property
- Melting point:
- 189°C
- alpha
- D18 +131° (c = 0.4 in chloroform); D20 +144° (c = 0.8 in chloroform)
- Boiling point:
- 464.47°C (rough estimate)
- Density
- 1.1117 (rough estimate)
- refractive index
- 1.6800 (estimate)
- storage temp.
- 2-8°C
- pka
- pKa 8.2 (Uncertain)
- Water Solubility
- 489.7mg/L(30 ºC)
- Merck
- 13,194
Safety
- Hazard Codes
- Xn
- Risk Statements
- 25-20/21/22
- Safety Statements
- 13-45-36
- RIDADR
- 1544
- RTECS
- AX8050000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Toxicity
- LD50 oral in rat: 360mg/kg
AJMALINE Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
Ajmaline ,Solvay Pharma
Uses
An antiarrhythmic agent isolated from Rauwolfia serpentina.
Uses
For use as an antiarrhythmic agent.
Definition
ChEBI: A monoterpenoid indole alkaloid that consists of ajmalan substituted at positions 17 and 21 by hydroxy groups.
Manufacturing Process
Ajmaline isolated from Rauwolfia sp. roots: Rauwolfia serpentine Benth.,
Rauwolfia vomitoria Afr., Rauwolfia canescens L.
Threshed roots of Rauwolfia canescens L. extracted with 5% solution of acetic
acid at room temperature for 24 h. Then extract was decanted to flask. This
extract was alkalified with ammonia (alkaloid salts were converted to alkaloid
bases). The obtained thus method solution was extracted with chloroform 3 or
more times. Then chloroform extract was chromatographed on column
through Al2O3 sorbent. After chromatography ajmalin was obtained, which had
melting point at 205°C (recyrstallization from methanol).
Therapeutic Function
Antiarrhythmic
Purification Methods
Ajmaline crystallises from MeOH or EtOAc containing a little H2O to give the trihydrate m 158-160o. This loses 1H2O at 110o and all H2O at 150o. [Beilstein 23 III/IV 3212.]
AJMALINE Preparation Products And Raw materials
Raw materials
Preparation Products
AJMALINE Suppliers
- Tel
- 010-82848833- ;010-82848833-
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com;market6@jkchemical.com
- Country
- China
- ProdList
- 96504
- Advantage
- 76
- Tel
- 21-61259100-
- Fax
- 86-21-61259102
- sh@meryer.com
- Country
- China
- ProdList
- 40268
- Advantage
- 62
- Tel
- 025-83697070-
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 19994
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32358
- Advantage
- 50
- Tel
- 86-21-58998985
- Fax
- (86) 21-58955996
- apisales@chemexpress.com.cn
- Country
- China
- ProdList
- 7557
- Advantage
- 61
- Tel
- 609-228-6898
- Fax
- 609-228-5909
- sales@medchemexpress.com
- Country
- United States
- ProdList
- 4787
- Advantage
- 58
- Tel
- 020-39119399-
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4485
- Advantage
- 55
- Tel
- 025-58378339;025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com;sales@sunlidabio.com
- Country
- China
- ProdList
- 3815
- Advantage
- 55
- Tel
- 0755-66853366-
- sales@chem-strong.com
- Country
- China
- ProdList
- 19252
- Advantage
- 56
- Tel
- 027-87465837-
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com;
- Country
- China
- ProdList
- 9363
- Advantage
- 58