TOMATIDINE
Definition Pharmaceutical Properties- Product Name
- TOMATIDINE
- CAS No.
- 77-59-8
- Chemical Name
- TOMATIDINE
- Synonyms
- Tomatidin;omatidine;TOMATADINE;TOMATIDINE;NSC 226903;TOMATIDINE(RG);Spirosolan-3-ol;Tomatidine, >98%;5alpha-Tomatidan-3beta-ol;Spirosolan-3-ol,(3β,5α,22β,25S)-
- CBNumber
- CB3774922
- Molecular Formula
- C27H45NO2
- Formula Weight
- 415.65
- MOL File
- 77-59-8.mol
TOMATIDINE Property
- Melting point:
- 210.5℃
- alpha
- D25 +8° (chloroform)
- Boiling point:
- 534.2°C (rough estimate)
- Density
- 1.0048 (rough estimate)
- refractive index
- 1.6840 (estimate)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 2.86 mg/mL (6.88 mM);Water : < 0.1 mg/mL (insoluble)
- pka
- 15.14±0.70(Predicted)
- LogP
- 6.150 (est)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 301066
- Product name
- Tomatidine
- Packaging
- 10mg
- Price
- $490
- Updated
- 2021/12/16
- Product number
- orb594522
- Product name
- Tomatidine
- Packaging
- 100mg
- Price
- $778.6
- Updated
- 2021/12/16
- Product number
- PXT0015864
- Product name
- TOMATIDINE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $782.23
- Updated
- 2021/12/16
- Product number
- CS-5821
- Product name
- Tomatidine
- Purity
- >98.0%
- Packaging
- 25mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-5821
- Product name
- Tomatidine
- Purity
- >98.0%
- Packaging
- 50mg
- Price
- $96
- Updated
- 2021/12/16
TOMATIDINE Chemical Properties,Usage,Production
Definition
Tomatidine is the aglycone derivative of tomatine. Tomatidine belongs to the chemical family known as Spirosolanes and Derivatives. These are steroidal alkaloids whose structure contains a spirosolane skeleton. Tomatine (the glycosylated form of tomatidine) is a mildly toxic glycoalkaloid or glycospirosolane found in the stems and leaves of tomato plants as well as in the fruit of unripened (green) tomatoes (up to 500 mg/kg).
Pharmaceutical Properties
Red, ripe tomatoes have somewhat reduced amounts of tomatine and tomatidine. Both tomatine and tomatidine possess antimicrobial, antifungal and antiviral properties. Tomatidine has been shown to exhibit anti-virulence activity against normal strains of Staphylococcus aureus as well as the ability to potentiate the effect of aminoglycoside antibiotics. Recent studies have shown that tomatidine stimulates mTORC1 signaling and anabolism, leading to accumulation of protein and mitochondria, and ultimately, cell growth. Furthermore, in mice, tomatidine has been shown to increase skeletal muscle mTORC1 signaling, reduce skeletal muscle atrophy, enhance recovery from skeletal muscle atrophy, stimulate skeletal muscle hypertrophy, and increase strength and exercise capacity. Tomatidine has also been shown to significantly inhibit cholesterol ester accumulation induced by acetylated LDL in human monocyte-derived macrophages in a dose-dependent manner. Tomatidine also inhibits cholesterol ester formation in Chinese hamster ovary cells overexpressing acyl-CoA:cholesterol acyl-transferase (ACAT)-1 or ACAT-2, suggesting that tomatidine suppresses both ACAT-1 and ACAT-2 activities. The oral administration of tomatidine to apoE-deficient mice significantly reduces levels of serum cholesterol, LDL-cholesterol, and the size of atherosclerotic lesions.
Chemical Properties
Crystals. Decomposes at 275–280C.
Definition
ChEBI: A 3beta-hydroxy steroid resulting from the substitution of the 3beta-hydrogen of tomatidane by a hydroxy group.
Purification Methods
Tomatidine forms plates from EtOAc. It is also purified by dissolving 80mg in *C6H6 and applying to an Al2O3 column (3.0g) and eluting with *C6H6, evaporating and recrystallising the residue three times from EtOAc. The hydrochloride has m 265-270o from EtOH and [] D 25 -5o (MeOH). [IR: Uhle J Am Chem Soc 83 1460 1961, Kessar et al. Tetrahedron 27 2869 1971, Schreiber & Adams Experientia 17 13 1961, Beilstein 27 III/IV 1950.]
TOMATIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
TOMATIDINE Suppliers
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View Lastest Price from TOMATIDINE manufacturers
- Product
- Tomatidine 77-59-8
- Price
- US $10.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2021-07-08
- Product
- Tomatidine 77-59-8
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-03-23
- Product
- tomatidine 77-59-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26