3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- Product Name
- 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- CAS No.
- 4687-37-0
- Chemical Name
- 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- Synonyms
- Ethyl veratroylacetate;ETHYL 3,4-DIMETHOXYBENZOYLACETATE;Ethyl 3,4-diMethoxybenzoylacetate 97%;Ethyl 3,4-dimethoxy-β-oxobenzenepropanoate;Ethyl 3-oxo-3-(3,4-dimethoxyphenyl)propanoate;ETHYL 3-(3,4-DIMETHOXYPHENYL)-3-OXOPROPANOATE;Benzenepropanoicacid, 3,4-dimethoxy-b-oxo-, ethyl ester;Benzenepropanoic acid, 3,4-dimethoxy-β-oxo-, ethyl ester;3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- CBNumber
- CB1294000
- Molecular Formula
- C13H16O5
- Formula Weight
- 252.26
- MOL File
- 4687-37-0.mol
3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Property
- Melting point:
- 37-41 °C (lit.)
- Boiling point:
- 150-160 °C(Press: 0.01 Torr)
- Density
- 1.136±0.06 g/cm3(Predicted)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 10.77±0.48(Predicted)
- Appearance
- Colorless to light yellow <37°C Solid,>41°C Liquid
- CAS DataBase Reference
- 4687-37-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 593168
- Product name
- Ethyl 3,4-dimethoxybenzoylacetate
- Purity
- 97%
- Packaging
- 5g
- Price
- $176
- Updated
- 2025/07/31
- Product number
- 593168
- Product name
- Ethyl 3,4-dimethoxybenzoylacetate
- Purity
- 97%
- Packaging
- 1g
- Price
- $73.8
- Updated
- 2023/06/20
- Product number
- FD146095
- Product name
- Ethyl 3-(3,4-Dimethoxyphenyl)-3-oxopropanoate
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 6402AB
- Product name
- Ethyl3-(3,4-dimethoxyphenyl)-3-oxopropanoate
- Packaging
- 1g
- Price
- $114
- Updated
- 2021/12/16
- Product number
- FD146095
- Product name
- Ethyl 3-(3,4-Dimethoxyphenyl)-3-oxopropanoate
- Packaging
- 2g
- Price
- $128
- Updated
- 2021/12/16
3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
1131-62-0
105-58-8
4687-37-0
GENERAL STEPS: The synthesis of ethyl 3,4-dimethoxybenzoylacetate from 3,4-dimethoxyacetophenone and diethyl carbonate was carried out as follows: first, 3,4-dimethoxyacetophenone (0.05 mol) was dissolved in toluene (50 mL) and then added slowly and dropwise to a solution containing diethyl carbonate (0.10 mol) and sodium hydride (0.15 mol, 60% mineral oil dispersion) (0.15 mol, 60% mineral oil dispersion). The reaction mixture was stirred at room temperature and heated to reflux for 30 minutes. Upon completion of the reaction, the mixture was poured into ice water, acidified with glacial acetic acid and subsequently extracted with ethyl acetate (3 x 100 mL). The organic phases were combined and dried with anhydrous magnesium sulfate. After removal of solvent by distillation under reduced pressure, the crude product was purified by silica gel column chromatography using dichloromethane as eluent to afford the target product ethyl 3,4-dimethoxybenzoylacetate. All the synthesized compounds were subjected to structural confirmation by 1H NMR, 13C NMR, IR and mass spectrometry.
References
[1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 17, p. 5064 - 5075
[2] Heterocycles, 1979, vol. 13, p. 239 - 246
[3] Journal of Medicinal Chemistry, 1997, vol. 40, # 20, p. 3217 - 3227
[4] Patent: JP2005/82549, 2005, A. Location in patent: Page/Page column 19-20
[5] Angewandte Chemie - International Edition, 2011, vol. 50, # 32, p. 7304 - 7307
3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Suppliers
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View Lastest Price from 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER manufacturers
- Product
- 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 4687-37-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-04
- Product
- Ethyl 3,4-diMethoxybenzoylacetate 4687-37-0
- Price
- US $1.00-22.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000KG
- Release date
- 2024-08-06
- Product
- 3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 4687-37-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11