METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE

METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE Property

Melting point:

243 °C (dec.)(lit.)

storage temp. 

Inert atmosphere,Room Temperature

form 

Crystalline Powder

color 

White

InChI

InChI=1S/C9H11NO2.ClH/c1-12-9(11)8-4-2-7(6-10)3-5-8;/h2-5H,6,10H2,1H3;1H

InChIKey

GIZCKBSSWNIUMZ-UHFFFAOYSA-N

SMILES

C(OC)(=O)C1=CC=C(CN)C=C1.[H]Cl

CAS DataBase Reference

6232-11-7

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29224999

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

Methyl 4-(aminomethyl)benzoate hydrochloride may be used in the preparation of methyl 4-((3-butyl-3-phenylureido)methyl)benzoate.

General Description

Methyl 4-(aminomethyl)benzoate hydrochloride is an amino acid ester hydrochloride. Its synthesis by esterification reaction has been reported. It plays a role during the preparation of a novel hepatitis C virus (HCV) helicase inhibitor.

Synthesis

4-(Aminomethyl)benzoic acid (302 mg, 2.00 mmol) was dissolved in methanol (30 mL) and thionyl chloride (1.16 mL, 16.0 mmol) was added slowly and dropwise at room temperature. The reaction mixture was stirred at room temperature overnight. Subsequently, the solvent was removed by distillation under reduced pressure to afford the target product, methyl 4-aminomethylbenzoate hydrochloride (15d), as a colorless solid in 390 mg (97%) yield with a melting point of 234 °C. The molecular formula was C9H12ClNO2 (molecular weight 201.7). Thin layer chromatography (TLC) analysis showed an Rf value of 0.22 (Expanding agent: ethyl acetate/1% diethylmethylamine, detection wavelength 254 nm). Nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 400 MHz, DMSO-D6) showed chemical shifts δ [ppm]: 3.86 (single peak, 3H, CO2CH3), 4.10 (single peak, 2H, H3NCH2), 7.63-7.67 (multiple peaks, 2H, 3-HB, 5-HB), 7.96-8.01 (multiple peaks, 2H, 2-HB, 6 -HB), 8.61 (broad peaks, 3H, NH3). Nuclear magnetic resonance carbon spectra (13C NMR, 101 MHz, DMSO-D6) showed chemical shifts δ [ppm]: 41.7 (1C, H3NCH2), 52.2 (1C, CO2CH3), 129.2 (2C, C-3B, C-5B), 129.3 (2C, C-2B, C-6B), 129.5 (1C, C-1B). 139.4 (1C, C-4B), 165.9 (1C, CO2CH3). Fourier transform infrared spectroscopy (FT-IR) showed absorption peaks ν [cm-1]: 2963 (NH3+), 2878 (C-H aliphatic), 2573 (NH3+), 1678 (C=O), 1597, 1578, 1477 (C=C aromatic), and 864 (aromatic ring out-of-plane bending vibration). High resolution mass spectrometry (HRMS, APCI) showed m/z = 166.0865 (calculated value C9H12NO2 [M+H]+: 166.0863). High performance liquid chromatography (HPLC) analysis showed retention time tR = 6.4 min and purity 99.9%.

References

[1] Angewandte Chemie - International Edition, 2011, vol. 50, # 21, p. 4872 - 4875
[2] European Journal of Medicinal Chemistry, 2017, vol. 129, p. 124 - 134
[3] Patent: US5585381, 1996, A