TNFSF4
- Product Name
- TNFSF4
- Chemical Name
- TNFSF4
- Synonyms
- Gp34;CD252;OX40L;OX4OL;TNLG2B;TNFSF4;Txgp1l;CD134L;OX40 Ligand human;Recombinant Human OX40L/TNFSF4 Protein, His Tag
- CBNumber
- CB12973176
- Formula Weight
- 0
- MOL File
- Mol file
TNFSF4 Property
- storage temp.
- -20°C
- form
- lyophilized
- color
- white to off-white
- biological source
- human
N-Bromosuccinimide Price
- Product number
- SRP3133
- Product name
- OX40 Ligand human
- Purity
- recombinant, expressed in Hi-5 Insect cells, ≥97% (SDS-PAGE), ≥97% (HPLC), suitable for cell culture
- Packaging
- 10μG
- Price
- $369
- Updated
- 2025/07/31
TNFSF4 Chemical Properties,Usage,Production
Uses
OX40L or tumor necrosis factor superfamily member 4 (TNFSF4), which is a member of the TNF superfamily of structurally related proteins, exists primarily as a type II membrane bound, non-covalently linked homotrimeric protein. This cytokine is expressed on antigen presenting cells (APCs), such as dendritic cells and activated B-cells, and also on various other cells such as vascular endothelial cells, mast cells, and natural killer cells. It has a 23 amino acid cytoplasmic tail and a 133 amino acid extracellular domain. The gene encoding this protein is localized on human chromosome 1q25 and has three exons. Recombinant OX40L is a glycosylated 133 amino acid protein corresponding to the extracellular TNF homologous domain of the full length transmembrane protein. It migrates with an apparent molecular mass of 15.5-25kDa on SDS-PAGE.
Biological Activity
OX40L signals specifically through the OX40 receptor, which is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. OX40/OX40L functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of regulated on activation, normal T cell expressed and secreted (RANTES) or chemokine ligand 5 (CCL5), interleukins-2 and -3, and interferon-γ (IFNγ). OX40/OX40L signaling plays an important role in immuno-regulatory communication and immune-tolerance. Polymorphisms in the TNFSF4 gene have been associated with autoimmune thyroid diseases (AITDs), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc).
TNFSF4 Preparation Products And Raw materials
Raw materials
Preparation Products
TNFSF4 Suppliers
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- 027-65317797 15926423062
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- QQ：422450190
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- China
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- 13121935750
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- 400-9019800
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