Kurarinol
- Product Name
- Kurarinol
- CAS No.
- 855746-98-4
- Chemical Name
- Kurarinol
- Synonyms
- 4'',5''-Dihydro-5''-hydroxysophoraflavanone G 5-methyl ether;KurarinolQ: What is Kurarinol Q: What is the CAS Number of Kurarinol;2-(2,4-dihydroxy-phenyl)-7-hydroxy-8-[2-(3-hydroxy-3-methyl-butyl)-3-methyl-but-3-enyl]-5-methoxy-chroman-4-one;(2S)-2-(2,4-Dihydroxyphenyl)-2,3-dihydro-7-hydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-, (2S)-
- CBNumber
- CB13037363
- Molecular Formula
- C26H32O7
- Formula Weight
- 456.53
- MOL File
- 855746-98-4.mol
Kurarinol Property
- Melting point:
- 166-169 °C
- Boiling point:
- 683.8±55.0 °C(Predicted)
- Density
- 1.250±0.06 g/cm3(Predicted)
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 7.54±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- CFN92533
- Product name
- Kurarinol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $468
- Updated
- 2021/12/16
Kurarinol Chemical Properties,Usage,Production
Uses
Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase[1].
Definition
ChEBI: A trihydroxyflavanone that is (2S)-flavanone substituted by hydroxy groups at positions 7, 2' and 4' , a methoxy group at position 5 and a (2S)-5-hydroxy-5-methyl-2-(prop-1-en-2-yl)hexyl group at position 8 respectively.
in vivo
Kurarinol (20 mg/kg; p.o.; daily; for 3 days) reduces serum lipid levels in high-Cholesterol diet induced hyperlipidemic rats[3].
| Animal Model: | Male Sprague-Dawley rats (120-130g), hypercholesterolemic models[3] |
| Dosage: | 20 mg/kg |
| Administration: | Oral administration, daily, for 3 days |
| Result: | Decreased serum TC, TG, and LDL-C levels. |
target
STAT | HBV | Tyrosinase
References
[1] Y B Ryu, et al. Kurarinol, tyrosinase inhibitor isolated from the root of Sophora flavescens. Phytomedicine. 2008 Aug;15(8):612-8. DOI:10.1016/j.phymed.2007.09.022
[2] Guangwen Shu, et al. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicol Appl Pharmacol. 2014 Dec 1;281(2):157-65. DOI:10.1016/j.taap.2014.06.021
[3] Hyun Young Kim, et al. Hypolipidemic effects of Sophora flavescens and its constituents in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. Biol Pharm Bull. 2008 Jan;31(1):73-8. DOI:10.1248/bpb.31.73