ChemicalBook > CAS DataBase List > ROR gamma-t-IN-1

ROR gamma-t-IN-1

Product Name
ROR gamma-t-IN-1
CAS No.
1426802-50-7
Chemical Name
ROR gamma-t-IN-1
Synonyms
GSK805;ROR gamma-t-IN-1;GSK805 (GSK-805);GSK805,N-(2,6-Dichloro-2'-(trifluoromethoxy)biphenyl-4-yl)-;4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one;N-(2,6-dichloro-2'-(trifluoromethoxy)biphenyl-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;N-[3,5-dichloro-4-[2-(trifluoromethoxy)phenyl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide;N-[2,6-Dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)benzeneacetamide;Benzeneacetamide, N-[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)-;N-(2,6-dichloro-2'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide
CBNumber
CB13048666
Molecular Formula
C23H18Cl2F3NO4S
Formula Weight
532.36
MOL File
1426802-50-7.mol
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ROR gamma-t-IN-1 Property

Boiling point:
617.1±55.0 °C(Predicted)
Density 
1.434±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF:3.0(Max Conc. mg/mL);5.64(Max Conc. mM)
DMSO:68.33(Max Conc. mg/mL);128.36(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.56(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);93.92(Max Conc. mM)
form 
A crystalline solid
pka
12.33±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
9002444
Product name
GSK805
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
9002444
Product name
GSK805
Purity
≥98%
Packaging
5mg
Price
$151
Updated
2024/03/01
Cayman Chemical
Product number
9002444
Product name
GSK805
Purity
≥98%
Packaging
10mg
Price
$235
Updated
2024/03/01
ChemScene
Product number
CS-5079
Product name
GSK805
Purity
97.14%
Packaging
10mg
Price
$280
Updated
2021/12/16
AK Scientific
Product number
2948DU
Product name
RORgamma-t-IN-1
Packaging
10mg
Price
$360
Updated
2021/12/16
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ROR gamma-t-IN-1 Chemical Properties,Usage,Production

Description

GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor''s putative ligand binding domain without exerting significant effects on DNA binding. It inhibits the expression of IL-17 (at 0.5 μM) in naïve CD4+ T cells activated under Th17-cell-polarizing conditions and affects the broader RORγt-dependent gene network, inhibiting the development and pathogenic function of Th17 cells. GSK805 significantly reduces the severity of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, when given orally to the hosts at 10 mg/kg daily beginning at the time of disease induction.

ROR gamma-t-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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1426802-50-7, ROR gamma-t-IN-1Related Search:

GSK8612 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol 1-(1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl)ethanone GSK8612 GSK6853 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid GSK620 GSK591 GSK5959 GSK872

  • ROR gamma-t-IN-1
  • GSK805
  • GSK805 (GSK-805)
  • N-(2,6-dichloro-2'-(trifluoromethoxy)biphenyl-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide
  • 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one
  • Benzeneacetamide, N-[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)-
  • N-[2,6-Dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)benzeneacetamide
  • N-[3,5-dichloro-4-[2-(trifluoromethoxy)phenyl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide
  • GSK805,N-(2,6-Dichloro-2'-(trifluoromethoxy)biphenyl-4-yl)-
  • N-(2,6-dichloro-2'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide
  • GSK 805,immunity,RAR-related orphan receptor,Inhibitor,GSK805,inhibit,ROR,oral,CNS penetrant,GSK-805,Th17 cell
  • N-(2,6-dichloro-2'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide
  • 1426802-50-7
  • C23H18Cl2F3NO4S