VR23

Product Name: VR23
CAS No.: 1624602-30-7
Chemical Name: VR23
Synonyms: VR23;CS-1579;VR23(VR-23);VR23 >=98% (HPLC);7-chloro-4-(4-((2,4-dinitrophenyl)sulfonyl)piperazin-1-yl)quinoline;7-Chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]quinoline;Quinoline, 7-chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]-
CBNumber: CB13049249
Molecular Formula: C19H16ClN5O6S
Formula Weight: 477.88
MOL File: 1624602-30-7.mol

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VR23 Property

storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥45.55 mg/mL in DMSO
form: Powder
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19133
Product name: VR23
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 19133
Product name: VR23
Purity: ≥98%
Packaging: 5mg
Price: $155
Updated: 2024/03/01

Cayman Chemical

Product number: 19133
Product name: VR23
Purity: ≥98%
Packaging: 10mg
Price: $274
Updated: 2024/03/01

Cayman Chemical

Product number: 19133
Product name: VR23
Purity: ≥98%
Packaging: 25mg
Price: $553
Updated: 2024/03/01

TRC

Product number: V767023
Product name: VR23
Packaging: 100mg
Price: $440
Updated: 2021/12/16

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VR23 Chemical Properties,Usage,Production

Description

VR23 is a chloroquine derivative that functions as a proteasome inhibitor (IC₅₀s = 1 nM, 50-100 nM, and 3 μM for trypsin-like, chymotrypsin-like, and caspase-like proteasomes, respectively). It also deregulates the activity of cyclin E and other centrosomal proteins, resulting in the induction of multiple centrosome amplification, abnormal spindle formation, uneven cytokinesis, irreversible mitotic arrest, and eventually apoptosis that is specific to cancer cells. In combination with the chymotrypsin-like proteasome inhibitor bortezomib , VR23 can produce a synergistic effect in killing multiple myeloma cells, including those that are resistant to bortezomib.

Uses

VR23 is a quinoline-sulfonyl hybrid proteasome inhibitor which is used in cancer therapeutics. Targets cancer via cycline E-mediated centrosome.

in vivo

vr23 was effective in controlling metastatic breast cancer cells and multiple myelomas [1]. in engrafted animals, the treatment with vr23 at 30 mg/kg twice per week for three weeks inhibited tumor growth effectively. following 24 hours pre-treatment with paclitaxel at 20mg/kg/week, the administration of vr23 enhanced the anti-tumor activity of paclitaxel by 70%. histological data showed that vr23 substantially decreased mitotic index, inhibited tumor infiltration into surrounding tissues and remarkably reduced tumor cell proliferation and angiogenesis [4].

References

[1]. pundir s, vu hy, solomon vr, et al. vr23: a quinoline-sulfonyl hybrid proteasome inhibitor that selectively kills cancer via cyclin e-mediated centrosome amplification. cancer research, 2015, 75(19): 4164-4175.
[2]. almond jb, cohen gm. the proteasome: a novel target for cancer chemotherapy. leukemia, 2002, 16(4): 433-443.
[3]. adams j, palombella vj, sausville ea, et al. proteasome inhibitors: a novel class of potent and effective antitumor agents. cancer research, 1999, 59(11): 2615-2622.
[4]. vu hyt, pundir s, solomon rv, et al. anticancer effects and mechanism of vr23, a novel chloroquine derivative. cancer research, 2014, 74(19 supplement): 4545-4545.

VR23 Preparation Products And Raw materials

Raw materials

Preparation Products

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VR23 Suppliers

China 75 India 1 United States 11 Global 87

MedChemexpress LLC

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Musechem

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InvivoChem

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Aladdin Scientific

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TargetMol Chemicals Inc.

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Cayman Chemical Company

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MedChemExpress

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1624602-30-7, VR23Related Search:

Vps VS-5584 VRT752271

VR23

7-Chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]quinoline

VR23(VR-23)

7-chloro-4-(4-((2,4-dinitrophenyl)sulfonyl)piperazin-1-yl)quinoline

CS-1579

Quinoline, 7-chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]-

VR23 >=98% (HPLC)

1624602-30-7

C19H16ClN5O6S