3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile
- Product Name
- 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile
- CAS No.
- 913830-15-6
- Chemical Name
- 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile
- Synonyms
- NS 9283;NS-9283;NS9283;NS 9283;NS-9283;NS9283;3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile;3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile;Benzonitrile, 3-[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]-;NS9283,Inhibitor,Nicotinic acetylcholine receptors,nAChR,inhibit
- CBNumber
- CB13049683
- Molecular Formula
- C14H8N4O
- Formula Weight
- 248.24
- MOL File
- 913830-15-6.mol
3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Property
- Boiling point:
- 469.9±55.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 3 mg/ml; Ethanol: Partially soluble
- form
- A crystalline solid
- pka
- 1.40±0.12(Predicted)
N-Bromosuccinimide Price
- Product number
- 29189
- Product name
- NS 9283
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 29189
- Product name
- NS 9283
- Packaging
- 25mg
- Price
- $420
- Updated
- 2024/03/01
- Product number
- 29189
- Product name
- NS 9283
- Packaging
- 5mg
- Price
- $122
- Updated
- 2024/03/01
- Product number
- 29189
- Product name
- NS 9283
- Packaging
- 10mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- 5112
- Product name
- NS9283
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $201
- Updated
- 2021/12/16
3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Chemical Properties,Usage,Production
Description
NS 9283 is a positive allosteric modulator of α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs) that potentiates ACh-induced currents in HEK293 cells expressing human α4β2 subunit-containing nAChRs (EC50 = 4 μM). In vivo, NS 9283 potentiates ABT-594 analgesic efficacy in rat models of carrageenan-induced thermal hyperalgesia, paw skin incision post-operative pain, and monoiodoacetate-induced osteoarthritis. It reduces nicotine, but not sucrose, self-administration and reinstatement in rats when administered at a dose of 3.5 mg/kg.
Uses
NS 9283 is a positive allosteric modulator of α4β2 receptor affecting the potency of acetylcholine (Ach) related events. This has been linked to affect on everyday brain function including cognitive function and pain alleviation.
storage
Store at +4°C