Fmoc-Lys(Pal-Glu-OtBu)-OH

ChemicalBook > CAS DataBase List > Fmoc-Lys(Pal-Glu-OtBu)-OH

Fmoc-Lys(Pal-Glu-OtBu)-OH

Product Name: Fmoc-Lys(Pal-Glu-OtBu)-OH
CAS No.: 1491158-62-3
Chemical Name: Fmoc-Lys(Pal-Glu-OtBu)-OH
Synonyms: Liraglutide Lys;Fmoc-Lys(Pal-Glu-OtBu);Fmoc-Lys(Pal-Glu-OtBu)-OH;Palm-Glu(Ot-Bu)-Fmoc-Lys-OH;Fmoc-L-Lys(Palm-L-Glu-OtBu)-OH;PLU-3(Fmoc-L-Lys(Palm-L-Glu-Otbu)-OH);Fmoc-L-Lys(Palm-L-Glu-OtBu)-OH main building block;(9H-Fluoren-9-yl)MethOxy]Carbonyl Lys(Pal-Glu-OtBu)-OH;N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-((S)-5-(tert-butoxy)-5-oxo-4-palmitamidopentanoyl)-L-lysine;N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-(N-alpha'-palmitoyl-L-glutamic-acid alpha'-t-butyl ester)-L-lysine
CBNumber: CB13054762
Molecular Formula: C46H69N3O8
Formula Weight: 792.06
MOL File: 1491158-62-3.mol

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Fmoc-Lys(Pal-Glu-OtBu)-OH Property

Boiling point:: 944.2±65.0 °C(Predicted)
Density: 1.099±0.06 g/cm3(Predicted)
pka: 3.88±0.21(Predicted)
InChIKey: SUFBOZUGILQOQW-FMQAFZDONA-N
SMILES: C(O)(=O)[C@@H](N(C1C2=C(C=CC=C2)C2=C1C=CC=C2)C(OC)=O)CCCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC)C(OC(C)(C)C)=O |&1:3,31,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: H950213
Product name: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[[(4S)-4-(hexadecanoylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoyl]amino]hexanoicacid
Packaging: 50mg
Price: $155
Updated: 2021/12/16

ChemScene

Product number: CS-0038825
Product name: Fmoc-Lys(Pal-Glu-OtBu)-OH
Packaging: 1g
Price: $230
Updated: 2021/12/16

ChemPep

Product number: 181247
Product name: Fmoc-Lys(Pal-Glu-OtBu)-OH
Packaging: 1g
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0038825
Product name: Fmoc-Lys(Pal-Glu-OtBu)-OH
Packaging: 100mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-0038825
Product name: Fmoc-Lys(Pal-Glu-OtBu)-OH
Packaging: 250mg
Price: $115
Updated: 2021/12/16

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Fmoc-Lys(Pal-Glu-OtBu)-OH Chemical Properties,Usage,Production

Uses

Fmoc-Lys(Pal-Glu-OtBu)-OH can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Uses

Fmoc-Lys (Pal-Glu-OtBu)-OH is a non-cleavable antibody-drug conjugates linker capable of synthesizing antibody-drug conjugates. It can also be used as an alkyl chain-based PROTAC linker for the synthesis of PROTACs.

Application

Fmoc-Lys(Pal-Glu-OtBu)-OH is a racemic, solid-phase, industrial building block for the synthesis of peptides and polypeptides. This product is used in the synthesis of liraglutide (a peptide), which is used to treat type 2 diabetes mellitus. It is synthesized by a solid phase process using coupling reactions with an acid labile linker. This product has been shown to be an efficient building block for the synthesis of peptides and polypeptides that have a sequence that can be varied by changing the protecting group on the amino acid.

Biological Activity

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

Synthesis

In a flask aqueous sodium carbonate (1.8 g) was prepared followed by addition of THF (800 mL) and then this mixture was cooled to 0-10 0C. To this mixture, (S)-2-((((9Hfluoren-9-yl)methoxy)carbonyl)amino)-6-aminohexanoic acid (4.59 g) was added. Then, a solution of 1 -(tert-butyl) 5-(2,5-dioxopyrrolidin-1-yl) palmitoyl-L-glutamate (corresponding to 5 g of 5-(tert-butoxy)-5-oxo-4-palmitamidopentanoic acid) prepared according to example 2, was slowly added to above mixture at about 5 0C. The reaction mixture was stirred for about 2 hours at 25 0C followed by addition of water (600 mL). The solvents were subjected to distillation and then the pH of the obtained compound is adjusted to 3.0 using 5N hydrochloric acid. The mixture was stirred for 1-2 hours and resulting solid was isolated filtration, washing with water (30 mL). The obtained solid was dried under vacuum for 8 hours at about 45°C to afford title compound in -85% yield.

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Fmoc-Lys(Pal-Glu-OtBu)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fmoc-Lys(Pal-Glu-OtBu)-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-Lys(Pal-Glu-OtBu)-OH 1491158-62-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-02-28

Hebei Mingeng Biotechnology Co., Ltd

Product: Fmoc-Lys(Pal-Glu-Otbu)-OH 1491158-62-3
Price: US $150.00/ASSAYS
Min. Order: 10g
Purity: more than 99.6%
Supply Ability: 500kg/month
Release date: 2021-11-24

Career Henan Chemical Co

Product: Fmoc-Lys(Pal-Glu-OtBu)-OH 1491158-62-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-07-04

1491158-62-3, Fmoc-Lys(Pal-Glu-OtBu)-OHRelated Search:

FMOC-D-4-Chlorophe FMOC-LYS(BOC)(ISOPROPYL)-OH Fmoc-Lys(nicotinoyl)-OH (R)-N-Acetyl-2-naphthylalanine Fmoc-D-Asn(Trt)-OH 4-[(AMinocarbonyl)aMino]-N-[(9H-fluoren-9-ylMethoxy)carbonyl]-D-phenylalanine Fmoc-D-homoArg(Et)2-OH·HCl (R)-N-Fmoc-(3-Pyridyl)alanine N-[(9H-Fluoren-9-ylMethoxy)carbonyl]-4-[[[(4S)-hexahydro-2,6-dioxo-4-pyriMidinyl]carbonyl]aMino]-L-phenylalanine Fmoc-L-beta-Homoarginine(Pmc) (s)-3-(fmoc-amino)-n-trityl-adipic acid 6-amide FMoc-D-4-Aph(tBu-CbM)-OH Fmoc-3-(2-Naphthyl)-D-alanine Fmoc-N-Me-Tyr(tBu)-OH FMOC-D-CIT-OH FMOC-D-alanine Fmoc-N'-Acetyl-L-lysine FMOC-LYS(ME)2-OH HCL

Fmoc-Lys(Pal-Glu-OtBu)-OH

N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N6-[N-(1-oxohexadecyl)-L-gamma-glutamyl]-L-lysine 1'-(1,1-dimethylethyl) ester

(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-6-((S)-5-(Tert-Butoxy)-5-Oxo-4-Palmitamidopentanamido)Hexanoic Acid

(9H-Fluoren-9-yl)MethOxy]Carbonyl Lys(Pal-Glu-OtBu)-OH

N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-(N-alpha'-palmitoyl-L-glutamic-acid alpha'-t-butyl ester)-L-lysine

Fmoc-L-Lys(Palm-L-Glu-OtBu)-OH

(2S)-6-[(4S)-5-(tert-butoxy)-4-hexadecanamido-5-oxopentanamido]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoic acid

L-Lysine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N6-[N-(1-oxohexadecyl)-L-γ-glutamyl]-, 1'-(1,1-dimethylethyl) ester

(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[[(4S)-4-(hexadecanoylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoyl]amino]hexanoic acid

Liraglutide Lys

PLU-3(Fmoc-L-Lys(Palm-L-Glu-Otbu)-OH)

Fmoc-Lys(Pal-Glu-OtBu)

N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-((S)-5-(tert-butoxy)-5-oxo-4-palmitamidopentanoyl)-L-lysine

Fmoc-L-Lys(Palm-L-Glu-OtBu)-OH main building block

Palm-Glu(Ot-Bu)-Fmoc-Lys-OH

(2S)-6-{[(4S)-5-tert-butoxy-4-(hexadecanoylamino)-5-oxopentanoyl]amino}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoic acid

1491158-62-3

C46H69N3O8