Azido-PEG6-CH2CO2t-butyl ester
- Product Name
- Azido-PEG6-CH2CO2t-butyl ester
- CAS No.
- 297162-49-3
- Chemical Name
- Azido-PEG6-CH2CO2t-butyl ester
- Synonyms
- N3-PEG6-COOtBu;Azido-PEG6-C1-Boc;N3-PEG6-CH2COOtBu;AZIDO-PEG6-CH2CO2TBU;Azido-PEG6-CH2COOtBu;Azido-PEG6-CH2COOH t-Bu Ester;Azido-PEG6-CH2CO2t-butyl ester;tert-Butyl 20-azido-3,6,9,12,15,18-hexaoxaic osanoate;N3-PEG6-CH2COOtBu/3,6,9,12,15,18-Hexaoxaeicosanoic acid, 20-azido-, 1,1-dimethylethyl ester
- CBNumber
- CB13062367
- Molecular Formula
- C18H35N3O8
- Formula Weight
- 421.49
- MOL File
- 297162-49-3.mol
N-Bromosuccinimide Price
- Product number
- BIPG1151
- Product name
- Azido-PEG6-CH2CO2t-butyl ester
- Packaging
- 250mg
- Price
- $662
- Updated
- 2021/12/16
- Product number
- AS104044
- Product name
- N3-PEG6-CH2COOtBu
- Purity
- 95+%
- Packaging
- 1g
- Price
- $730
- Updated
- 2021/12/16
- Product number
- BP-22132
- Product name
- Azido-PEG6-CH2CO2-t-Bu
- Purity
- 98%
- Packaging
- 1g
- Price
- $1200
- Updated
- 2021/12/16
- Product number
- B-0923
- Product name
- N3-PEG6-CH2COOtBu
- Purity
- 97%
- Packaging
- 0.5g
- Price
- $385
- Updated
- 2021/12/16
Azido-PEG6-CH2CO2t-butyl ester Chemical Properties,Usage,Production
Description
Azido-PEG6-CH2CO2-t-Bu contain an azide group and a t-butyl ester. PEG spacer increases reagent's solubility in aqueous media. The azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic condition.
Uses
Azido-PEG6-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-C1-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG6-CH2CO2t-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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