CCG-203971

Product Name: CCG-203971
CAS No.: 1443437-74-8
Chemical Name: CCG-203971
Synonyms: 3-Piperidinecarboxamide, N-(4-chlorophenyl)-1-[3-(2-furanyl)benzoyl]-;203971;CCG-203971;CCG 203971;CCG203971;CCG-203971;N-(4-Chlorophenyl)-1-[3-(2-furanyl)benzoyl]-3-piperidinecarboxamide;N-(4-chlorophenyl)-1-[3-(furan-2-yl)benzoyl]piperidine-3-carboxamide;Rho,Ras,Inhibitor,SRF,CCG 203971,CCG-203971,MKL1,inhibit,MRTF,anti-metastasis,PC-3,migration
CBNumber: CB13067539
Molecular Formula: C23H21ClN2O3
Formula Weight: 408.88
MOL File: 1443437-74-8.mol

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CCG-203971 Property

Boiling point:: 656.0±55.0 °C(Predicted)
Density: 1.305±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO:81.0(Max Conc. mg/mL);198.1(Max Conc. mM)
form: powder
pka: 13.69±0.70(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1422
Product name: CCG-203971
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $70.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1422
Product name: CCG-203971
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $289
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.30985
Product name: MICAL-2 Inhibitor II, CCG-203971 - CAS 1443437-74-8 - Calbiochem
Packaging: 10mg
Price: $185
Updated: 2023/01/07

Cayman Chemical

Product number: 15075
Product name: CCG-203971
Purity: ≥90%
Packaging: 5mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 15075
Product name: CCG-203971
Purity: ≥90%
Packaging: 10mg
Price: $89
Updated: 2024/03/01

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CCG-203971 Chemical Properties,Usage,Production

Uses

CCG 203971 acts as an antifibrotic agent, inhibiting fibrosis through targeting the MRTF/SRF gene transcription pathway. Inhibits the invasion of prostate cancer cells and acts as a potent anti-proliferative agent.

Biochem/physiol Actions

CCG-203971 is an inhibitor of the Rho/MKL1/SRF transcriptional pathway, which has been shown to play a role in metastasis of melanoma and breast cancer and clinically associated with castration-resistant prostate cancer. CCG-203971 is a second-generation analog of CCG-1423 (SML0987) with an IC50 of 4.2 μM vs 1 μM for CCG-1423, but less cytotoxicity. In mouse studies, CCG-203971 inhibited invasion of PC-3 prostate cancer cells and was well tolerated up to doses of 100 mg/kg IP over 5 days. The Rho/MRTF/SRF pathway has also been shown to be involved in multiple types of solid organ fibrosis. CCG-203971 repressed both matrix-stiffness and TGF-β-mediated fibrogenesis in human colonic myofibroblasts and showed antifibrotic activity in a murine model of skin injury and in pulmonary fibrosis lung fibroblasts.

CCG-203971 Preparation Products And Raw materials

Raw materials

Preparation Products

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CCG-203971 Suppliers

China 63 India 2 United Kingdom 2 United States 9 USA 1 Global 77

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55013243 15324716602
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ShangHai Caerulum Pharma Discovery Co., Ltd.

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Shanghai CanSpecsci Instrument Co., Ltd.

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Sigma-Aldrich

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Country: China
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Shanghai Lollane Biological Technology Co.,Ltd.

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Zhengzhou Guancheng Laboratory equipment Sales

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Pharmacodia (Beijing) Co.,Ltd

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Shanghai EFE Biological Technology Co., Ltd.

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Tianjin Kailiqi Biotechnology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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1443437-74-8, CCG-203971Related Search:

CCG-203971

CCG 203971;CCG203971;CCG-203971

N-(4-Chlorophenyl)-1-[3-(2-furanyl)benzoyl]-3-piperidinecarboxamide

N-(4-chlorophenyl)-1-[3-(furan-2-yl)benzoyl]piperidine-3-carboxamide

203971

3-Piperidinecarboxamide, N-(4-chlorophenyl)-1-[3-(2-furanyl)benzoyl]-

Rho,Ras,Inhibitor,SRF,CCG 203971,CCG-203971,MKL1,inhibit,MRTF,anti-metastasis,PC-3,migration

1443437-74-8