GPR39-C3

ChemicalBook > CAS DataBase List > GPR39-C3

Product Name: GPR39-C3
CAS No.: 1621175-65-2
Chemical Name: GPR39-C3
Synonyms: CS-2374;GPR39-C3;TC-G-1008;GPR39C3;GPR39 C3;TC-G-1008 (GPR39-C3);TC-G-1008, 10 mM in DMSO;inhibit,GHSR,Inhibitor,Growth hormone secretagogue receptor,TC G 1008,TCG1008;N-[3-Chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide;N-(3-Chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide;Methanesulfonamide, N-[3-chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]-
CBNumber: CB13126726
Molecular Formula: C18H19ClN6O2S
Formula Weight: 418.9
MOL File: 1621175-65-2.mol

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GPR39-C3 Property

Boiling point:: 662.1±65.0 °C(Predicted)
Density: 1.462±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO:63.97(Max Conc. mg/mL);152.72(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:5):0.16(Max Conc. mg/mL);0.38(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);4.77(Max Conc. mM)
form: A crystalline solid
pka: 7.43±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25445
Product name: GPR39-C3
Purity: ≥95%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 25445
Product name: GPR39-C3
Purity: ≥95%
Packaging: 5mg
Price: $137
Updated: 2024/03/01

Cayman Chemical

Product number: 25445
Product name: GPR39-C3
Purity: ≥95%
Packaging: 10mg
Price: $238
Updated: 2024/03/01

Cayman Chemical

Product number: 25445
Product name: GPR39-C3
Purity: ≥95%
Packaging: 25mg
Price: $515
Updated: 2024/03/01

Tocris

Product number: 5355
Product name: TC-G1008
Purity: ≥98%(HPLC)
Packaging: 10
Price: $227
Updated: 2021/12/16

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GPR39-C3 Chemical Properties,Usage,Production

Description

GPR39-C3 is a potent agonist of the orphan G protein-coupled receptor GPR39 with EC₅₀ values of 0.8 and 0.4 nM for cAMP production in HEK293 cells expressing human and rat receptors, respectively. It is selective for GPR39 over a panel of kinases (IC₅₀s = >10 μM), ghrelin and neurotensin-1 receptors (IC₅₀s = >30 μM), and a variety of enzymes, transporters, or G protein-coupled receptors. GPR39-C3 increases secretion of glucagon-like peptide 1 (GLP-1; ) in STC-1 mouse enteroendocrine cells (EC₅₀ = 0.06 μM) and is protective against cytokine-induced cell death in INS-1E rat insulinoma cells (EC₅₀ = 0.02 μM). In vivo, GPR39-C3 (30 mg/kg) increases the amount of active GLP-1 in sera by 6-fold in glucose-challenged mice when administered concurrently with a dipeptidyl peptidase 4 (DPP-4) inhibitor.

Uses

TC-G 1008 is the first potent, selective, and orally bioavailable GPR39 agonist.

storage

Store at +4°C

GPR39-C3 Preparation Products And Raw materials

Raw materials

Preparation Products

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1621175-65-2, GPR39-C3Related Search:

GPR39-C3

TC-G-1008

N-[3-Chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide

GPR39C3;GPR39 C3

CS-2374

TC-G-1008 (GPR39-C3)

Methanesulfonamide, N-[3-chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]-

N-(3-Chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide

inhibit,GHSR,Inhibitor,Growth hormone secretagogue receptor,TC G 1008,TCG1008

TC-G-1008, 10 mM in DMSO

1621175-65-2

16211175-65-2