GPR39-C3
- Product Name
- GPR39-C3
- CAS No.
- 1621175-65-2
- Chemical Name
- GPR39-C3
- Synonyms
- CS-2374;GPR39-C3;TC-G-1008;GPR39C3;GPR39 C3;TC-G-1008 (GPR39-C3);TC-G-1008, 10 mM in DMSO;inhibit,GHSR,Inhibitor,Growth hormone secretagogue receptor,TC G 1008,TCG1008;N-[3-Chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide;N-(3-Chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide;Methanesulfonamide, N-[3-chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]-
- CBNumber
- CB13126726
- Molecular Formula
- C18H19ClN6O2S
- Formula Weight
- 418.9
- MOL File
- 1621175-65-2.mol
GPR39-C3 Property
- Boiling point:
- 662.1±65.0 °C(Predicted)
- Density
- 1.462±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:63.97(Max Conc. mg/mL);152.72(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:5):0.16(Max Conc. mg/mL);0.38(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);4.77(Max Conc. mM) - form
- A crystalline solid
- pka
- 7.43±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 25445
- Product name
- GPR39-C3
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 25445
- Product name
- GPR39-C3
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $137
- Updated
- 2024/03/01
- Product number
- 25445
- Product name
- GPR39-C3
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $238
- Updated
- 2024/03/01
- Product number
- 25445
- Product name
- GPR39-C3
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $515
- Updated
- 2024/03/01
- Product number
- 5355
- Product name
- TC-G1008
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $227
- Updated
- 2021/12/16
GPR39-C3 Chemical Properties,Usage,Production
Description
GPR39-C3 is a potent agonist of the orphan G protein-coupled receptor GPR39 with EC50 values of 0.8 and 0.4 nM for cAMP production in HEK293 cells expressing human and rat receptors, respectively. It is selective for GPR39 over a panel of kinases (IC50s = >10 μM), ghrelin and neurotensin-1 receptors (IC50s = >30 μM), and a variety of enzymes, transporters, or G protein-coupled receptors. GPR39-C3 increases secretion of glucagon-like peptide 1 (GLP-1; ) in STC-1 mouse enteroendocrine cells (EC50 = 0.06 μM) and is protective against cytokine-induced cell death in INS-1E rat insulinoma cells (EC50 = 0.02 μM). In vivo, GPR39-C3 (30 mg/kg) increases the amount of active GLP-1 in sera by 6-fold in glucose-challenged mice when administered concurrently with a dipeptidyl peptidase 4 (DPP-4) inhibitor.
Uses
TC-G 1008 is the first potent, selective, and orally bioavailable GPR39 agonist.
storage
Store at +4°C