FIIN-3
- Product Name
- FIIN-3
- CAS No.
- 1637735-84-2
- Chemical Name
- FIIN-3
- Synonyms
- FIN-3;FIIN-3;CS-2331;FIIN3; FIIN 3;FIIN3; FIIN 3; FIIN-3;Inhibitor,FIIN 3,FIIN-3,HER1,FIIN3,ErbB-1,Epidermal growth factor receptor,inhibit,Fibroblast growth factor receptor,EGFR,FGFR;2-Propenamide, N-[4-[[[[(2,6-dichloro-3,5-dimethoxyphenyl)amino]carbonyl][6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]methyl]phenyl]-
- CBNumber
- CB13133445
- Molecular Formula
- C34H36Cl2N8O4
- Formula Weight
- 691.61
- MOL File
- 1637735-84-2.mol
FIIN-3 Property
- Boiling point:
- 909.4±65.0 °C(Predicted)
- Density
- 1.379±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Acetonitrile: sparingly soluble; Methanol: sparingly soluble
- form
- A crystalline solid
- pka
- 10.78±0.70(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 20709
- Product name
- FIIN-3
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 20709
- Product name
- FIIN-3
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 20709
- Product name
- FIIN-3
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $283
- Updated
- 2024/03/01
- Product number
- 20709
- Product name
- FIIN-3
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $618
- Updated
- 2024/03/01
- Product number
- F336510
- Product name
- FIIN-3
- Packaging
- 1mg
- Price
- $145
- Updated
- 2021/12/16
FIIN-3 Chemical Properties,Usage,Production
Description
FIIN-3 is an inhibitor of FGF receptors (FGFRs; IC50s = 13, 21, 31, and 35 nM for recombinant FGFR1-4, respectively). It is selective for FGFRs over a panel of 456 kinases at a concentration of 1 μM, however, it does inhibit EGFR (IC50 = 204 nM). FIIN-3 inhibits growth of Ba/F3 cells that are dependent on the kinase activity of wild-type FGFR1-4 as well as gatekeeper mutant FGFR2 and FGFR3 (EC50s = <1-69 nM) and inhibits FGFR-dependent signaling in a concentration-dependent manner in FGFR2TEL/V564M-dependent Ba/F3 cells. FIIN-3 also inhibits growth in a panel of cancer cell lines (EC50s = 1.4-499 nM).
Uses
FIIN-?3 is FGFR inhibitor. It can be used in synthetic preparation and complex with EGFR kinase of crystal structure; development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.
Definition
ChEBI: N-[4-[[[(2,6-dichloro-3,5-dimethoxyanilino)-oxomethyl]-[6-[4-(4-methyl-1-piperazinyl)anilino]-4-pyrimidinyl]amino]methyl]phenyl]-2-propenamide is a member of piperazines.
FIIN-3 Preparation Products And Raw materials
Raw materials
Preparation Products
FIIN-3 Suppliers
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
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- +1-800-259-7612
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- +1-800-259-7612
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- United States
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- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6393
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- 58
- Tel
- +1 (732)236-3202
- sales@cckinase.com
- Country
- United States
- ProdList
- 2738
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- Tel
- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 52927
- Advantage
- 58
- Tel
- +1-781-999-5354
- support@targetmol.com
- Country
- United States
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