4-Bromo-6-chloro-indan-1-one

Product Name: 4-Bromo-6-chloro-indan-1-one
CAS No.: 1260017-94-4
Chemical Name: 4-Bromo-6-chloro-indan-1-one
Synonyms: 4-Bromo-6-chloro-1-indanone;4-Bromo-6-chloro-indan-1-one;4-Bromo-6-chloro-2,3-dihydro-1H-inden-1-one;1H-Inden-1-one, 4-bromo-6-chloro-2,3-dihydro-;(S)-2-amino-3-(6-methoxynaphthalen-2-yl)propanoic acid
CBNumber: CB13139250
Molecular Formula: C9H6BrClO
Formula Weight: 245.5
MOL File: 1260017-94-4.mol

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4-Bromo-6-chloro-indan-1-one Property

storage temp.: Sealed in dry,Room Temperature
Appearance: Off-white to light brown Solid
InChI: InChI=1S/C9H6BrClO/c10-8-4-5(11)3-7-6(8)1-2-9(7)12/h3-4H,1-2H2
InChIKey: WCCKBUGGMIUBNX-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C(Br)=CC(Cl)=C2)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B592955
Product name: 4-bromo-6-chloro-2,3-dihydro-1H-inden-1-one
Packaging: 10mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: 7789DV
Product name: 4-Bromo-6-chloro-2,3-dihydro-1H-inden-1-one
Packaging: 2.5g
Price: $1232
Updated: 2021/12/16

Crysdot

Product number: CD12168083
Product name: 4-Bromo-6-chloro-2,3-dihydro-1H-inden-1-one
Purity: 97%
Packaging: 100mg
Price: $78
Updated: 2021/12/16

Crysdot

Product number: CD12168083
Product name: 4-Bromo-6-chloro-2,3-dihydro-1H-inden-1-one
Purity: 97%
Packaging: 250mg
Price: $126
Updated: 2021/12/16

Crysdot

Product number: CD12168083
Product name: 4-Bromo-6-chloro-2,3-dihydro-1H-inden-1-one
Purity: 97%
Packaging: 1g
Price: $314
Updated: 2021/12/16

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4-Bromo-6-chloro-indan-1-one Chemical Properties,Usage,Production

Synthesis

66192-04-9

1260017-94-4

The general procedure for the synthesis of 4-bromo-6-chloro-2,3-dihydro-1H-inden-1-one using 3-(2-bromo-4-chlorophenyl)propionic acid as starting material was as follows: oxalyl chloride (3.6 mL) was added slowly and dropwise under stirring to a solution of 3-(2-bromo-4-chlorophenyl)propionic acid (4.4 g) in dichloromethane (40 mL). The reaction mixture was stirred continuously at 40 °C for 2 hours. Subsequently, aluminum trichloride (AlCl3, 2.7 g) was added to the reaction system and the mixture was heated to reflux and maintained for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and partitioned between ethyl acetate and saturated aqueous sodium bicarbonate (NaHCO3). The aqueous phase was extracted twice with ethyl acetate, all organic phases were combined and washed with brine. The organic layer was dried over anhydrous sodium sulfate (Na2SO4) and evaporated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent cyclohexane/ethyl acetate (95:5→90:10) to afford the target compound 4-bromo-6-chloro-2,3-dihydro-1H-inden-1-one. Yield: 3.7 g; liquid chromatography (Method 1): retention time (tR) = 1.20 min; mass spectrometry (ESI+): m/z = 245 [M + H]+.

References

[1] Patent: WO2013/144098, 2013, A1. Location in patent: Page/Page column 123
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 16, p. 3368 - 3372

4-Bromo-6-chloro-indan-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-6-chloro-indan-1-one Suppliers

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