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4-Bromo-6-chloro-indan-1-one

Product Name
4-Bromo-6-chloro-indan-1-one
CAS No.
1260017-94-4
Chemical Name
4-Bromo-6-chloro-indan-1-one
Synonyms
4-Bromo-6-chloro-1-indanone;4-Bromo-6-chloro-indan-1-one;4-Bromo-6-chloro-2,3-dihydro-1H-inden-1-one;1H-Inden-1-one, 4-bromo-6-chloro-2,3-dihydro-;(S)-2-amino-3-(6-methoxynaphthalen-2-yl)propanoic acid
CBNumber
CB13139250
Molecular Formula
C9H6BrClO
Formula Weight
245.5
MOL File
1260017-94-4.mol
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4-Bromo-6-chloro-indan-1-one Property

storage temp. 
Sealed in dry,Room Temperature
Appearance
Off-white to light brown Solid
InChI
InChI=1S/C9H6BrClO/c10-8-4-5(11)3-7-6(8)1-2-9(7)12/h3-4H,1-2H2
InChIKey
WCCKBUGGMIUBNX-UHFFFAOYSA-N
SMILES
C1(=O)C2=C(C(Br)=CC(Cl)=C2)CC1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B592955
Product name
4-bromo-6-chloro-2,3-dihydro-1H-inden-1-one
Packaging
10mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
7789DV
Product name
4-Bromo-6-chloro-2,3-dihydro-1H-inden-1-one
Packaging
2.5g
Price
$1232
Updated
2021/12/16
Crysdot
Product number
CD12168083
Product name
4-Bromo-6-chloro-2,3-dihydro-1H-inden-1-one
Purity
97%
Packaging
100mg
Price
$78
Updated
2021/12/16
Crysdot
Product number
CD12168083
Product name
4-Bromo-6-chloro-2,3-dihydro-1H-inden-1-one
Purity
97%
Packaging
250mg
Price
$126
Updated
2021/12/16
Crysdot
Product number
CD12168083
Product name
4-Bromo-6-chloro-2,3-dihydro-1H-inden-1-one
Purity
97%
Packaging
1g
Price
$314
Updated
2021/12/16
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4-Bromo-6-chloro-indan-1-one Chemical Properties,Usage,Production

Synthesis

66192-04-9

1260017-94-4

The general procedure for the synthesis of 4-bromo-6-chloro-2,3-dihydro-1H-inden-1-one using 3-(2-bromo-4-chlorophenyl)propionic acid as starting material was as follows: oxalyl chloride (3.6 mL) was added slowly and dropwise under stirring to a solution of 3-(2-bromo-4-chlorophenyl)propionic acid (4.4 g) in dichloromethane (40 mL). The reaction mixture was stirred continuously at 40 °C for 2 hours. Subsequently, aluminum trichloride (AlCl3, 2.7 g) was added to the reaction system and the mixture was heated to reflux and maintained for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and partitioned between ethyl acetate and saturated aqueous sodium bicarbonate (NaHCO3). The aqueous phase was extracted twice with ethyl acetate, all organic phases were combined and washed with brine. The organic layer was dried over anhydrous sodium sulfate (Na2SO4) and evaporated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent cyclohexane/ethyl acetate (95:5→90:10) to afford the target compound 4-bromo-6-chloro-2,3-dihydro-1H-inden-1-one. Yield: 3.7 g; liquid chromatography (Method 1): retention time (tR) = 1.20 min; mass spectrometry (ESI+): m/z = 245 [M + H]+.

References

[1] Patent: WO2013/144098, 2013, A1. Location in patent: Page/Page column 123
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 16, p. 3368 - 3372

4-Bromo-6-chloro-indan-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-6-chloro-indan-1-one Suppliers

China 23 India 1 United States 1 Global 25
Shijiazhuang Dushi Biopharmaceutical Technology Co., Ltd
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13102890206 18032066297
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China
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LABTER PHARMATECH(BEIJING) CO.,LTD
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010-56330744 18310155299
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010-56330744
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sales@labter.com.cn
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China
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Nanjing XiZe Biotechnology CO., Ltd.
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025-58362220 0086-15250997978
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025-58362220
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sale@njxizebio.com
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China
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Changzhou Hopschain Chemical Co.,Ltd.
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0519-85528066 13775048983
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0519-85528066
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sales@hopschem.com
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China
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Aikon International Limited
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025-66061636 18013972705
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(3)02557626880
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Suzhou Liyuan Biomedical Technology Co., Ltd.
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Chengdu Feibai Pharmaceutical Co., Ltd.
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028-84641798 18782128315
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3302391190@qq.com
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China
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Shijiazhuang Dongzhi Chemical Co., Ltd.
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18032763683 13102890206; 18032763683
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QQ：442112647
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442112647@qq.com
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China
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Amel Pharmatech Corporation
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027-888-4366503
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888-502-1736
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China
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Suzhou Xinghuo Biotechnology Co., Ltd.
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1260017-94-4, 4-Bromo-6-chloro-indan-1-oneRelated Search:

4-CHLORO-5-METHOXY-1-INDANONE 4-Bromo-6-fluoroisoquinolin-1(2H)-one 4-BROMO-5-FLUORO-2,3-DIHYDRO-1H-INDEN-1-ONE 4-Bromo-5-chloro-2,3-dihydro-1H-inden-1-one

  • 4-Bromo-6-chloro-indan-1-one
  • 4-Bromo-6-chloro-2,3-dihydro-1H-inden-1-one
  • 1H-Inden-1-one, 4-bromo-6-chloro-2,3-dihydro-
  • 4-Bromo-6-chloro-1-indanone
  • (S)-2-amino-3-(6-methoxynaphthalen-2-yl)propanoic acid
  • 1260017-94-4