ChemicalBook > CAS DataBase List > 4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacid
4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacid
- Product Name
- 4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacid
- CAS No.
- 1370448-25-1
- Chemical Name
- 4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacid
- Synonyms
- Clesacostat;PF-05221304;EOS-62091;PF-07055341;CAS:1370448-25-1;PF-05221304 ，S6145;STAT5 Inhibitor III;PF 05221304,PF05221304;PF-05221304(Clesacostat);PF-05221304 + PF-06865571
- CBNumber
- CB13142744
- Molecular Formula
- C28H30N4O5
- Formula Weight
- 502.56
- MOL File
- 1370448-25-1.mol
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4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacid Property
- Boiling point:
- 745.3±60.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 100 mg/mL (198.98 mM);Ethanol: 5 mg/mL (9.95 mM)
- pka
- 3.93±0.10(Predicted)
- Water Solubility
- Water: Insoluble
- InChIKey
- LXZMHBHEXAELHH-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(C2=NC(OC)=CC(C(N3CCC4(CC3)CC(=O)C3=C(C4)C=NN3C(C)C)=O)=C2)C=C1
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4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacid Chemical Properties,Usage,Production
Description
PF-05221304 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 12.4 and 8.7 nM, respectively).1 It inhibits de novo lipid synthesis (IC50 = 61 nM) and increases fatty acid oxidation in primary human hepatocytes. PF-05221304 reduces the accumulation of triglycerides composed of de novo-derived fatty acids but not dietary essential fatty acids in primary human hepatocytes. In vivo, PF-05221304 (10 and 100 mg/kg) reduces hepatic malonyl-CoA production and de novo lipogenesis in rats. It reduces hepatic fibrosis, alanine transaminase (ALT) and aspartate aminotransferase (AST) levels, and triglyceride accumulation in a rat model of non-alcoholic steatohepatitis (NASH) induced by a choline-deficient and high-fat diet (CDAHFD).WARNING This product is not for human or veterinary use.
4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacid Preparation Products And Raw materials
Raw materials
Preparation Products
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