SYP-5

Product Name: SYP-5
CAS No.: 1384268-04-5
Chemical Name: SYP-5
Synonyms: SYP-5;SYP5; SYP 5;SYP-5 >=98% (HPLC);(E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(thiophen-2-yl)prop-2-en-1-one;2-Propen-1-one, 1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(2-thienyl)-, (2E)-;SYP-5,Inhibitor,HIFs,Hypoxia-inducible factors,SYP5,inhibit,HIF-PH,SYP 5,HIF/HIF Prolyl-Hydroxylase
CBNumber: CB13145907
Molecular Formula: C18H16O3S
Formula Weight: 312.38
MOL File: 1384268-04-5.mol

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SYP-5 Property

Boiling point:: 502.0±50.0 °C(Predicted)
Density: 1.263±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF:30.0(Max Conc. mg/mL);96.04(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.96(Max Conc. mM)
DMSO:25.0(Max Conc. mg/mL);80.03(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);3.2(Max Conc. mM)
form: A solid
pka: 7.12±0.40(Predicted)
color: Yellow to orange

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6108
Product name: SYP-5
Purity: 99.68%
Packaging: 5mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-6108
Product name: SYP-5
Purity: 99.68%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-6108
Product name: SYP-5
Purity: 99.68%
Packaging: 50mg
Price: $490
Updated: 2021/12/16

ChemScene

Product number: CS-6108
Product name: SYP-5
Purity: 99.68%
Packaging: 100mg
Price: $900
Updated: 2021/12/16

DC Chemicals

Product number: DC10436
Product name: SYP-5
Purity: >98%
Packaging: 250mg
Price: $1250
Updated: 2021/12/16

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SYP-5 Chemical Properties,Usage,Production

Biological Activity

SYP-5, an inhibitor of Hypoxia-inducible factor-1 (HIF-1), inhibits tumor cell migration and invasion and tumor angiogenesis.

in vitro

SYP-5 inhibits hypoxia-induced upregulation of HIF-1. It inhibits HIF-1 and downstream gene expression in Hep3B and Bcap37 cells. It inhibits tumor cell migration and invasion, as well as tumor angiogenesis, which are mediated by suppressing PI3K/AKT- and MAPK/ERK-dependent HIF-1 pathway. The proteins of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 that are targets of HIF-1, are down -regulated by SYP-5.

target

Target	Value
HIF-1 ()

SYP-5 Preparation Products And Raw materials

Raw materials

Preparation Products

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SYP-5 Suppliers

China 37 United States 6 Global 43

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4512
Advantage: 55

Shanghai Beckham Medical Technology Co., Ltd

Tel: 021-13816613772 13816613772
Fax: QQ: 12922499
Email: huahero21@sina.com
Country: China
ProdList: 442
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7267
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 918
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11217
Advantage: 58

1384268-04-5, SYP-5Related Search:

SYP-5

SYP5; SYP 5

2-Propen-1-one, 1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(2-thienyl)-, (2E)-

SYP-5 >=98% (HPLC)

SYP-5,Inhibitor,HIFs,Hypoxia-inducible factors,SYP5,inhibit,HIF-PH,SYP 5,HIF/HIF Prolyl-Hydroxylase

(E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(thiophen-2-yl)prop-2-en-1-one

1384268-04-5