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SYP-5

Product Name
SYP-5
CAS No.
1384268-04-5
Chemical Name
SYP-5
Synonyms
SYP-5;SYP5; SYP 5;SYP-5 >=98% (HPLC);(E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(thiophen-2-yl)prop-2-en-1-one;2-Propen-1-one, 1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(2-thienyl)-, (2E)-;SYP-5,Inhibitor,HIFs,Hypoxia-inducible factors,SYP5,inhibit,HIF-PH,SYP 5,HIF/HIF Prolyl-Hydroxylase
CBNumber
CB13145907
Molecular Formula
C18H16O3S
Formula Weight
312.38
MOL File
1384268-04-5.mol
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SYP-5 Property

Boiling point:
502.0±50.0 °C(Predicted)
Density 
1.263±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF:30.0(Max Conc. mg/mL);96.04(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.96(Max Conc. mM)
DMSO:25.0(Max Conc. mg/mL);80.03(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);3.2(Max Conc. mM)
form 
A solid
pka
7.12±0.40(Predicted)
color 
Yellow to orange
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-6108
Product name
SYP-5
Purity
99.68%
Packaging
5mg
Price
$70
Updated
2021/12/16
ChemScene
Product number
CS-6108
Product name
SYP-5
Purity
99.68%
Packaging
10mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-6108
Product name
SYP-5
Purity
99.68%
Packaging
50mg
Price
$490
Updated
2021/12/16
ChemScene
Product number
CS-6108
Product name
SYP-5
Purity
99.68%
Packaging
100mg
Price
$900
Updated
2021/12/16
DC Chemicals
Product number
DC10436
Product name
SYP-5
Purity
>98%
Packaging
250mg
Price
$1250
Updated
2021/12/16
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SYP-5 Chemical Properties,Usage,Production

Biological Activity

SYP-5, an inhibitor of Hypoxia-inducible factor-1 (HIF-1), inhibits tumor cell migration and invasion and tumor angiogenesis.

in vitro

SYP-5 inhibits hypoxia-induced upregulation of HIF-1. It inhibits HIF-1 and downstream gene expression in Hep3B and Bcap37 cells. It inhibits tumor cell migration and invasion, as well as tumor angiogenesis, which are mediated by suppressing PI3K/AKT- and MAPK/ERK-dependent HIF-1 pathway. The proteins of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 that are targets of HIF-1, are down -regulated by SYP-5.

target

TargetValue
HIF-1
()

SYP-5 Preparation Products And Raw materials

Raw materials

Preparation Products

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SYP-5 Suppliers

China 37 United States 6 Global 43
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

1384268-04-5, SYP-5Related Search:


  • SYP-5
  • SYP5; SYP 5
  • 2-Propen-1-one, 1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(2-thienyl)-, (2E)-
  • SYP-5 >=98% (HPLC)
  • SYP-5,Inhibitor,HIFs,Hypoxia-inducible factors,SYP5,inhibit,HIF-PH,SYP 5,HIF/HIF Prolyl-Hydroxylase
  • (E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(thiophen-2-yl)prop-2-en-1-one
  • 1384268-04-5