ChemicalBook > CAS DataBase List > OTX 008
OTX 008
- Product Name
- OTX 008
- CAS No.
- 286936-40-1
- Chemical Name
- OTX 008
- Synonyms
- PTX 008;Calixarene 0118;OTX008, 10 mM in DMSO;OTX008 (Calixarene 0118;Calix[4]arene compound 0118;OTX008 (Synonyms: Calixarene 0118;PTX 008,OTX 008,Galectin,Calixarene0118,PTX-008,inhibit,OTX008,Calixarene-0118,OTX-008,Inhibitor;2,2',2'',2'''-(1,3,5,7(1,3)-Tetrabenzenacyclooctaphane-12,32,52,72-tetrayltetrakis(oxy))tetrakis(N-(2-(dimethylamino)ethyl)acetamide);2,2',2'',2'''-(1,3,5,7(1,3)-Tetrabenzenacyclooctaphane-12,32,52,72-tetrayltetrakis(oxy))tetrakis(N-(2-(dimethylamino)ethyl)acetamide);Acetamide, 2,2',2'',2'''-[pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecaene-25,26,27,28-tetrayltetrakis(oxy)]tetrakis[N-[2-(dimethylamino)ethyl]-
- CBNumber
- CB13146348
- Molecular Formula
- C52H72N8O8
- Formula Weight
- 937.18
- MOL File
- 286936-40-1.mol
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OTX 008 Property
- Boiling point:
- 1143.4±65.0 °C(Predicted)
- Density
- 1.155±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 1 mg/ml; DMSO: 2 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 0.5 mg/ml
- form
- A crystalline solid
- pka
- 13.84±0.46(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 23130
- Product name
- OTX008
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $68
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 23130
- Product name
- OTX008
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $121
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 23130
- Product name
- OTX008
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $535
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 23130
- Product name
- OTX008
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $936
- Updated
- 2024/03/01
ChemScene
- Product number
- CS-0016572
- Product name
- OTX008
- Purity
- 99.36%
- Packaging
- 25mg
- Price
- $590
- Updated
- 2021/12/16
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OTX 008 Chemical Properties,Usage,Production
Biological Activity
OTX008 (Calixarene 0118, PTX008), a calixarene derivative, is a selective inhibitor of galectin-1 (Gal1) with antitumor activity.
in vivo
OTX008 inhibits growth of A2780-1A9 xenografts. OTX008 treatment is associated with down-regulation of Gal1 and Ki67 in treated tumours, as well as decreased microvessel density and VEGFR2 expression. Finally, combination studies show OTX008 synergy with several cytotoxic and targeted therapies, principally when OTX008 is administered first.
target
| Target | Value |
| galectin-1 () |
OTX 008 Preparation Products And Raw materials
Raw materials
Preparation Products
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OTX 008 Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- --
- Fax
- --
- cayman@caymanchem.com
- Country
- United States
- ProdList
- 6213
- Advantage
- 81
- Tel
- --
- Fax
- --
- sales@medchemexpress.com
- Country
- United States
- ProdList
- 6398
- Advantage
- 58