Amiselimod(MT-1303) hydrochloride

Product Name: Amiselimod(MT-1303) hydrochloride
CAS No.: 942398-84-7
Chemical Name: Amiselimod(MT-1303) hydrochloride
Synonyms: Amiselimod HCl;Amiselimod.HCl,MT1303;MT-1303 HYDROCHLORIDE;Amiselimod, MT-1303(HCl);Amiselimod, MT-1303(HCI);Amiselimod hydrochloride;Amiselimod(MT-1303) hydrochloride;Amiselimod hydrochloride, 10 mM in DMSO;Amiselimod hydrochloride (MT-1303 hydrochloride);MT-1303 HYDROCHLORIDE;MT 1303 HYDROCHLORIDE;MT1303 HYDROCHLORIDE
CBNumber: CB13146676
Molecular Formula: C19H31ClF3NO3
Formula Weight: 413.91
MOL File: 942398-84-7.mol

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Amiselimod(MT-1303) hydrochloride Property

storage temp.: Store at -20°C
solubility: DMF: 25 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 20 mg/nl; Ethanol: 15 mg/ml
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20970
Product name: Amiselimod (hydrochloride)
Purity: ≥95%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 20970
Product name: Amiselimod (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 20970
Product name: Amiselimod (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $198
Updated: 2024/03/01

Cayman Chemical

Product number: 20970
Product name: Amiselimod (hydrochloride)
Purity: ≥95%
Packaging: 25mg
Price: $330
Updated: 2024/03/01

ChemScene

Product number: CS-5972
Product name: Amiselimodhydrochloride
Purity: 99.02%
Packaging: 5mg
Price: $336
Updated: 2021/12/16

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Amiselimod(MT-1303) hydrochloride Chemical Properties,Usage,Production

Uses

Amiselimod (MT-1303) hydrochloride is converted to its active metabolite Amiselimod phosphate by sphingosine kinases in vivo. Amiselimod hydrochloride is an orally active and high selectivity sphingosine 1-phosphate receptor-1 (S1P1) agonist, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators. Amiselimod hydrochloride inhibits chronic colitis via inhibiting infiltration of colitogenic Th1 and Th17 cells into the colon. Amiselimod hydrochloride inhibits lupus nephritis by reducing the infiltration of autoreactive T cells into the kidneys. Amiselimod hydrochloride is promising for research of autoimmune diseases[1][2][3][4].

References

[1] Sugahara K et al. Amiselimod, a novel sphingosine 1-phosphate receptor-1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk. Br J Pharmacol. 2016 Oct 7. DOI:10.1111/bph.13641
[2] Kappos L et al. Safety and efficacy of amiselimod in relapsing multiple sclerosis (MOMENTUM): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Neurol. 2016 Oct;15(11):1148-59. DOI:10.1016/S1474-4422(16)30192-2
[3] Shimano K, et al. Amiselimod (MT-1303), a novel sphingosine 1-phosphate receptor-1 functional antagonist, inhibits progress of chronic colitis induced by transfer of CD4+CD45RBhigh T cells. PLoS One. 2019 Dec 5;14(12):e0226154. DOI:10.1371/journal.pone.0226154
[4] Sugahara K, et al. Amiselimod (MT-1303), a Novel Sphingosine 1-Phosphate Receptor-1 Modulator, Potently Inhibits the Progression of Lupus Nephritis in Two Murine SLE Models. J Immunol Res. 2019 Dec 23;2019:5821589. DOI:10.1155/2019/5821589

Amiselimod(MT-1303) hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Amiselimod(MT-1303) hydrochloride Suppliers

China 63 United States 8 USA 1 Global 72

MedChemexpress LLC

Tel: 021-58955995
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Email: sales@medchemexpress.cn
Country: United States
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Musechem

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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Aladdin Scientific

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Cayman Chemical Company

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Country: United States
ProdList: 6213
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View Lastest Price from Amiselimod(MT-1303) hydrochloride manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Amiselimod hydrochloride 942398-84-7
Price: US $4.90/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10KG
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Amiselimod hydrochloride 942398-84-7
Price: US $4.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-24

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