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3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide

Product Name
3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide
CAS No.
863604-64-2
Chemical Name
3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide
Synonyms
3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide;Benzamide, 3-fluoro-N-methoxy-N-methyl-4-nitro-
CBNumber
CB13146919
Molecular Formula
C9H9FN2O4
Formula Weight
228.18
MOL File
863604-64-2.mol
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3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide Property

Boiling point:
411.0±35.0 °C(Predicted)
Density 
1.365±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
7308DN
Product name
3-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide
Packaging
250mg
Price
$114
Updated
2021/12/16
Crysdot
Product number
CD12022691
Product name
3-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide
Purity
97%
Packaging
1g
Price
$297
Updated
2021/12/16
Alichem
Product number
863604642
Product name
3-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide
Packaging
1g
Price
$356.38
Updated
2021/12/16
Crysdot
Product number
CD12022691
Product name
3-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide
Purity
97%
Packaging
5g
Price
$891
Updated
2021/12/16
Alichem
Product number
863604642
Product name
3-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide
Packaging
5g
Price
$1058.76
Updated
2021/12/16
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3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide Chemical Properties,Usage,Production

Synthesis

403-21-4

6638-79-5

863604-64-2

General procedure for the synthesis of 3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide from 3-fluoro-4-nitrobenzoic acid and N-methoxymethylamine hydrochloride: 3-fluoro-4-nitrobenzoic acid (100 g, 540 mmol), EDCI (155.3 g, 810 mmol), NMM (178 mL. 1.62 mol) and N-methoxymethylamine hydrochloride (79.0 g, 810 mmol). The reaction mixture was stirred at room temperature for 17 h under nitrogen protection. Upon completion of the reaction, the reaction mixture was diluted with 1N hydrochloric acid (1 L) and transferred to a separatory funnel to separate the organic phase. The organic phase was washed sequentially with 1N sodium hydroxide solution (2 x 500mL) and water (250mL). All aqueous layers were back-extracted with ethyl acetate (2 × 500 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 102.3 g (448 mmol, 83% yield) of a yellow solid product. The product was confirmed by NMR hydrogen spectroscopy (DMSO-d6): δ 8.22-8.18 (t, J=8.0 Hz, 1H), 7.79-7.76 (d, J=11.5 Hz, 1H), 7.60-7.58 (d, J=8.3 Hz, 1H), 3.56 (s, 3H), 3.28 (s, 3H); the mass spectrometry analysis showed that [M+H]+= 229.1; liquid chromatography-mass spectrometry analysis showed a retention time of 2.27 min.

References

[1] Patent: WO2005/121147, 2005, A1. Location in patent: Page/Page column 105; 106
[2] Patent: WO2005/80380, 2005, A1. Location in patent: Page/Page column 21;26
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 15, p. 4050 - 4054

3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide Suppliers

China 26 India 1 United States 2 Global 29
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
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China
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Finetech Industry Limited
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027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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71826
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Aikon International Limited
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025-66061636 18013972705
Fax
(3)02557626880
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qqyang@aikonchem.com
Country
China
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Jinan Yaoyan Pharmaceutical Co., Ltd.
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Fax
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jnyaoyan@163.com
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China
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Angel Pharmatech, Ltd.
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QQ3358272972
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3358272972@qq.com
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China
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Nanjing Meihao Pharmaceutical Technology Co., Ltd.
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meitaochem@126.com
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meitaochem@126.com
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China
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19103
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Finetech Industry Limited
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+86-27-8746-5837 +8619945049750
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86 27 87772287
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info@finetechnology-ind.com
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China
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Career Henan Chemica Co
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+86-0371-86658258 +8613203830695
Fax
0371-86658258
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laboratory@coreychem.com
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China
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30229
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Zhengzhou Convergence Chemical Co. LTD
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0371-0371-53736046 13393710386
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QQ:2853979814
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2853979814@qq.com
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863604-64-2, 3-fluoro-N-methoxy-N-methyl-4-nitrobenzamideRelated Search:


  • 3-fluoro-N-methoxy-N-methyl-4-nitrobenzamide
  • Benzamide, 3-fluoro-N-methoxy-N-methyl-4-nitro-
  • 863604-64-2