IOX4

Product Name: IOX4
CAS No.: 1154097-71-8
Chemical Name: IOX4
Synonyms: IOX4;IOX4 NEW;IOX4; IOX-4; IOX 4;PHD2 inhibitor IOX4;IOX4, 10 mM in DMSO;IOX4 (PHD2 inhibitor IOX4);t-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate;tert-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate;IOX 4,HIF-PH,HIFs,Hypoxia-inducible factors,IOX4,IOX-4,inhibit,HIF/HIF Prolyl-Hydroxylase,Inhibitor;3-Pyridinecarboxylic acid, 6-[2,5-dihydro-5-oxo-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl]-, 1,1-dimethylethyl ester
CBNumber: CB13152631
Molecular Formula: C15H16N6O3
Formula Weight: 328.33
MOL File: 1154097-71-8.mol

More

Less

IOX4 Property

Melting point:: >190° (dec.)
Boiling point:: 502.2±60.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: Refrigerator, Under inert atmosphere
solubility: DMSO (Sparingly, Sonicated), Methanol (Slightly, Sonicated)
form: Solid
pka: 1.36±0.29(Predicted)
color: Light Beige to Beige

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 18181
Product name: IOX4
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 18181
Product name: IOX4
Purity: ≥98%
Packaging: 10mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 18181
Product name: IOX4
Purity: ≥98%
Packaging: 25mg
Price: $324
Updated: 2024/03/01

Cayman Chemical

Product number: 18181
Product name: IOX4
Purity: ≥98%
Packaging: 50mg
Price: $575
Updated: 2024/03/01

TRC

Product number: I737010
Product name: IOX4
Packaging: 250mg
Price: $1440
Updated: 2021/12/16

More

Less

IOX4 Chemical Properties,Usage,Production

Description

IOX4 is a potent inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; IC₅₀ = 1.6 nM). It displays >1,000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases, including JMJD isoforms, FBXL11, JARID1C, BBOX1, FIH, and FTO. IOX4 is active in vivo, inhibiting prolyl hydroxylation and increasing HIF-1α levels in cells (IC₅₀ values range from 5.6 to 11.7 μM) and inducing HIF-1α and HIF-2α expression in mice. The induction of HIF expression in mice occurs in the brain as well as in the liver, kidney, and heart, indicating that IOX4 penetrates the blood-brain barrier.

Uses

IOX4 is a triazole based potent and selective inhibitor of hypoxia-inducible factor (HIF) prolyl-hydroxylase. It induces HIFα in cells of mouse brain. It is useful for studies that aim to validate the upregulation of HIF for treatment of cerebral diseases such as stroke.

References

[1] MUN CHIANG CHAN. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.[J]. ACS Applied Bio Materials, 2015: e0132004. DOI: 10.1371/journal.pone.0132004

IOX4 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

IOX4 Suppliers

China 60 United States 8 Global 68

HangZhou YuHao Chemical Technology Co., Ltd.

Tel: 0571-82693216
Fax: 0571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 2028
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Guangzhou Zhiya Chemdrugs Co.,Ltd

Tel: 18122150900
Fax: QQ:2869377561
Email: sculk28@163.com
Country: China
ProdList: 646
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2989
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1944
Advantage: 55

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
Advantage: 58

Aishilun biotechnology (Shanghai) co., LTD

Tel: 021-50676523 18019098996
Email: info@acelybio.com
Country: China
ProdList: 3960
Advantage: 58

More

Less

View Lastest Price from IOX4 manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: IOX4 1154097-71-8
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-13

1154097-71-8, IOX4Related Search:

IOX4

tert-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate

3-Pyridinecarboxylic acid, 6-[2,5-dihydro-5-oxo-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl]-, 1,1-dimethylethyl ester

t-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate

IOX4; IOX-4; IOX 4

PHD2 inhibitor IOX4

IOX4 NEW

IOX 4,HIF-PH,HIFs,Hypoxia-inducible factors,IOX4,IOX-4,inhibit,HIF/HIF Prolyl-Hydroxylase,Inhibitor

IOX4, 10 mM in DMSO

IOX4 (PHD2 inhibitor IOX4)

1154097-71-8