IOX4
- Product Name
- IOX4
- CAS No.
- 1154097-71-8
- Chemical Name
- IOX4
- Synonyms
- IOX4;IOX4 NEW;IOX4; IOX-4; IOX 4;PHD2 inhibitor IOX4;t-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate;tert-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate;IOX 4,HIF-PH,HIFs,Hypoxia-inducible factors,IOX4,IOX-4,inhibit,HIF/HIF Prolyl-Hydroxylase,Inhibitor;3-Pyridinecarboxylic acid, 6-[2,5-dihydro-5-oxo-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl]-, 1,1-dimethylethyl ester
- CBNumber
- CB13152631
- Molecular Formula
- C15H16N6O3
- Formula Weight
- 328.33
- MOL File
- 1154097-71-8.mol
IOX4 Property
- Melting point:
- >190° (dec.)
- Boiling point:
- 502.2±60.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator, Under inert atmosphere
- solubility
- DMSO (Sparingly, Sonicated), Methanol (Slightly, Sonicated)
- form
- Solid
- pka
- 1.36±0.29(Predicted)
- color
- Light Beige to Beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 18181
- Product name
- IOX4
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 18181
- Product name
- IOX4
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $138
- Updated
- 2024/03/01
- Product number
- 18181
- Product name
- IOX4
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $324
- Updated
- 2024/03/01
- Product number
- 18181
- Product name
- IOX4
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $575
- Updated
- 2024/03/01
- Product number
- I737010
- Product name
- IOX4
- Packaging
- 250mg
- Price
- $1440
- Updated
- 2021/12/16
IOX4 Chemical Properties,Usage,Production
Description
IOX4 is a potent inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; IC50 = 1.6 nM). It displays >1,000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases, including JMJD isoforms, FBXL11, JARID1C, BBOX1, FIH, and FTO. IOX4 is active in vivo, inhibiting prolyl hydroxylation and increasing HIF-1α levels in cells (IC50 values range from 5.6 to 11.7 μM) and inducing HIF-1α and HIF-2α expression in mice. The induction of HIF expression in mice occurs in the brain as well as in the liver, kidney, and heart, indicating that IOX4 penetrates the blood-brain barrier.
Uses
IOX4 is a triazole based potent and selective inhibitor of hypoxia-inducible factor (HIF) prolyl-hydroxylase. It induces HIFα in cells of mouse brain. It is useful for studies that aim to validate the upregulation of HIF for treatment of cerebral diseases such as stroke.
IOX4 Preparation Products And Raw materials
Raw materials
Preparation Products
IOX4 Suppliers
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6393
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57511
- Advantage
- 58
- Tel
- +1-781-999-5354
- support@targetmol.com
- Country
- United States
- ProdList
- 19973
- Advantage
- 58