ChemicalBook > CAS DataBase List > R-IMPP

R-IMPP

Product Name: R-IMPP
CAS No.: 2133832-83-2
Chemical Name: R-IMPP
Synonyms: R-IMPP;PF-00932239 (R-IMPP);R-IMPP, 10 mM in DMSO;Benzenepropanamide, N-1-isoquinolinyl-4-methoxy-N-(3R)-3-piperidinyl-;(R)-N-(Isoquinolin-1-yl)-3-(4-methoxyphenyl)-N-(piperidin-3-yl)propanamide;Serine endopeptidases,PF-00932239,PF 00932239,inhibit,Ser/Thr Protease,RIMPP,R-IMPP,Inhibitor,Threonine proteases,R IMPP,PF00932239,Serine proteases
CBNumber: CB13155117
Molecular Formula: C24H27N3O2
Formula Weight: 389.49
MOL File: 2133832-83-2.mol

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R-IMPP Property

Boiling point:: 594.4±50.0 °C(Predicted)
Density: 1.186±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 1 mg/ml; DMSO: 10 mg/ml
form: A crystalline solid
pka: 9.14±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20861
Product name: (R)-IMPP
Packaging: 1mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 20861
Product name: (R)-IMPP
Packaging: 25mg
Price: $1075
Updated: 2024/03/01

Cayman Chemical

Product number: 20861
Product name: (R)-IMPP
Packaging: 5mg
Price: $288
Updated: 2024/03/01

Cayman Chemical

Product number: 20861
Product name: (R)-IMPP
Packaging: 10mg
Price: $539
Updated: 2024/03/01

ChemScene

Product number: CS-7579
Product name: R-IMPP
Purity: 99.36%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

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R-IMPP Chemical Properties,Usage,Production

Description

(R)-IMPP is a cell-permeable inhibitor of the secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9; IC₅₀ = 4.8 μM). It promotes the uptake of LDL cholesterol in hepatoma cells by increasing LDL receptor levels. (R)-IMPP apparently impairs PCSK9 secretion by causing transcript-dependent inhibition of PCSK9 translation.

Uses

R-IMPP (PF-00932239) is an anti-secretagogue of PCSK9 (IC50=4.8 μM), which targets the 80S ribosome to inhibit PCSK9 protein translation[1].

References

[1] Petersen DN, et al. A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation. Cell Chem Biol. 2016 Nov 17;23(11):1362-1371 DOI:10.1016/j.chembiol.2016.08.016

R-IMPP Preparation Products And Raw materials

Raw materials

Preparation Products

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R-IMPP Suppliers

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2133832-83-2, R-IMPPRelated Search:

R-IMPP

Benzenepropanamide, N-1-isoquinolinyl-4-methoxy-N-(3R)-3-piperidinyl-

PF-00932239 (R-IMPP)

(R)-N-(Isoquinolin-1-yl)-3-(4-methoxyphenyl)-N-(piperidin-3-yl)propanamide

Serine endopeptidases,PF-00932239,PF 00932239,inhibit,Ser/Thr Protease,RIMPP,R-IMPP,Inhibitor,Threonine proteases,R IMPP,PF00932239,Serine proteases

R-IMPP, 10 mM in DMSO

2133832-83-2