UK-371804

Product Name: UK-371804
CAS No.: 256477-09-5
Chemical Name: UK-371804
Synonyms: UK-371804;UK-371804 (UK371804;Urokinase inhitibor 1;Urokinase inhibitor 1;UK-371804, 10 mM in DMSO;UK-371804 (Urokinase inhitibor 1);2-((4-Chloro-1-guanidinoisoquinoline)-7-sulfonamido)-2-methylpropanoic acid;UK 371804,UK-371804,Inhibitor,PAI-1,inhibit,Plasminogen activator inhibitor-1;2-(1-carbamimidamido-4-chloroisoquinoline-7-sulfonamido)-2-methylpropanoic acid;N-[[1-[(Aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methylalanine
CBNumber: CB13160423
Molecular Formula: C14H16ClN5O4S
Formula Weight: 385.83
MOL File: 256477-09-5.mol

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UK-371804 Property

storage temp.: Store at -20°C
solubility: DMSO:5.0(Max Conc. mg/mL);2.59(Max Conc. mM)
form: A crystalline solid
color: White to off-white
CAS DataBase Reference: 256477-09-5

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27225
Product name: UK 371804
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 27225
Product name: UK 371804
Packaging: 25mg
Price: $410
Updated: 2024/03/01

Cayman Chemical

Product number: 27225
Product name: UK 371804
Packaging: 10mg
Price: $184
Updated: 2024/03/01

ChemScene

Product number: CS-6457
Product name: UK-371804
Purity: >98.0%
Packaging: 5mg
Price: $144
Updated: 2021/12/16

ChemScene

Product number: CS-6457
Product name: UK-371804
Purity: >98.0%
Packaging: 10mg
Price: $252
Updated: 2021/12/16

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UK-371804 Chemical Properties,Usage,Production

Description

UK-371804 is a potent and selectiveurokinase-type plasmogen activator (uPA)inhibitor. It has excellent selectivityover tPA, plasmin, Factor IXa and Xa.In vitro, it is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 microM). In vivo, in a porcine acute excisional wound modelfollowing topical delivery, it is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. It has the potential for the treatment of chronic dermal ulcers.

Uses

UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM.

in vivo

In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM^[1].

References

http://www.dcchemicals.com/product_show-UK_371804.html
http://adisinsight.springer.com/drugs/800026963
Fish, P. V., et al. "Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. "Journal of Medicinal Chemistry 50.10(2007):2341.

UK-371804 Preparation Products And Raw materials

Raw materials

Preparation Products

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UK-371804 Suppliers

China 66 United States 7 Global 73

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 984
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2990
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9126
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Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12476
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
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Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
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View Lastest Price from UK-371804 manufacturers

Career Henan Chemical Co

Product: UK-371804 256477-09-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-20

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2-(1-carbamimidamido-4-chloroisoquinoline-7-sulfonamido)-2-methylpropanoic acid

UK-371804, 10 mM in DMSO

2-((4-Chloro-1-guanidinoisoquinoline)-7-sulfonamido)-2-methylpropanoic acid

UK-371804 (UK371804

256477-09-5

C14H16ClN5O4S