UK-371804
- Product Name
- UK-371804
- CAS No.
- 256477-09-5
- Chemical Name
- UK-371804
- Synonyms
- UK-371804;UK-371804 (UK371804;Urokinase inhitibor 1;Urokinase inhibitor 1;UK-371804, 10 mM in DMSO;UK-371804 (Urokinase inhitibor 1);2-((4-Chloro-1-guanidinoisoquinoline)-7-sulfonamido)-2-methylpropanoic acid;UK 371804,UK-371804,Inhibitor,PAI-1,inhibit,Plasminogen activator inhibitor-1;2-(1-carbamimidamido-4-chloroisoquinoline-7-sulfonamido)-2-methylpropanoic acid;N-[[1-[(Aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methylalanine
- CBNumber
- CB13160423
- Molecular Formula
- C14H16ClN5O4S
- Formula Weight
- 385.83
- MOL File
- 256477-09-5.mol
UK-371804 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:5.0(Max Conc. mg/mL);2.59(Max Conc. mM)
- form
- A crystalline solid
- color
- White to off-white
- CAS DataBase Reference
- 256477-09-5
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 27225
- Product name
- UK 371804
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $107
- Updated
- 2026/04/30
- Product number
- 27225
- Product name
- UK 371804
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $203
- Updated
- 2026/04/30
- Product number
- 27225
- Product name
- UK 371804
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $451
- Updated
- 2026/04/30
- Product number
- 27225
- Product name
- UK 371804
- Packaging
- 5mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 27225
- Product name
- UK 371804
- Packaging
- 25mg
- Price
- $410
- Updated
- 2024/03/01
UK-371804 Chemical Properties,Usage,Production
Description
UK-371804 is a potent and selectiveurokinase-type plasmogen activator (uPA)inhibitor. It has excellent selectivityover tPA, plasmin, Factor IXa and Xa.In vitro, it is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 microM). In vivo, in a porcine acute excisional wound modelfollowing topical delivery, it is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. It has the potential for the treatment of chronic dermal ulcers.
Uses
UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM.
in vivo
In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM[1].
References
http://www.dcchemicals.com/product_show-UK_371804.html
http://adisinsight.springer.com/drugs/800026963
Fish, P. V., et al. "Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. "Journal of Medicinal Chemistry 50.10(2007):2341.
UK-371804 Preparation Products And Raw materials
Raw materials
Preparation Products
UK-371804 Suppliers
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
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- 021-61350663 13052117465
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- 021-61350662
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- China
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- 021-61312847; 18021002903
- Fax
- QQ:3008007432
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- China
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- 89689
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- 60
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- 15076683720
- Fax
- 022-23754520
- klq@cw-bio.com
- Country
- China
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- 9697
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- 55
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 7999
- Advantage
- 62
- Tel
- 021-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2987
- Advantage
- 58
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
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- 9550
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- 58
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- 0-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
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- China
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- 9955
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- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 0519-83246372 13585352506
- Fax
- 0519-83246372
- Country
- China
- ProdList
- 1844
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- 58
View Lastest Price from UK-371804 manufacturers
- Product
- UK-371804 256477-09-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-20