UK-371804

ChemicalBook > CAS DataBase List > UK-371804

Product Name: UK-371804
CAS No.: 256477-09-5
Chemical Name: UK-371804
Synonyms: UK-371804;Urokinase inhitibor 1;Urokinase inhibitor 1;UK-371804 (Urokinase inhitibor 1);UK 371804,UK-371804,Inhibitor,PAI-1,inhibit,Plasminogen activator inhibitor-1;2-(1-carbamimidamido-4-chloroisoquinoline-7-sulfonamido)-2-methylpropanoic acid;N-[[1-[(Aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methylalanine;Alanine, N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-
CBNumber: CB13160423
Molecular Formula: C14H16ClN5O4S
Formula Weight: 385.83
MOL File: 256477-09-5.mol

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UK-371804 Property

storage temp.: Store at -20°C
solubility: DMSO:5.0(Max Conc. mg/mL);2.59(Max Conc. mM)
form: A crystalline solid
color: White to off-white
CAS DataBase Reference: 256477-09-5

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27225
Product name: UK 371804
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 27225
Product name: UK 371804
Packaging: 25mg
Price: $410
Updated: 2024/03/01

Cayman Chemical

Product number: 27225
Product name: UK 371804
Packaging: 10mg
Price: $184
Updated: 2024/03/01

ChemScene

Product number: CS-6457
Product name: UK-371804
Purity: >98.0%
Packaging: 5mg
Price: $144
Updated: 2021/12/16

ChemScene

Product number: CS-6457
Product name: UK-371804
Purity: >98.0%
Packaging: 50mg
Price: $780
Updated: 2021/12/16

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UK-371804 Chemical Properties,Usage,Production

Description

UK-371804 is a potent and selectiveurokinase-type plasmogen activator (uPA)inhibitor. It has excellent selectivityover tPA, plasmin, Factor IXa and Xa.In vitro, it is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 microM). In vivo, in a porcine acute excisional wound modelfollowing topical delivery, it is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. It has the potential for the treatment of chronic dermal ulcers.

References

http://www.dcchemicals.com/product_show-UK_371804.html
http://adisinsight.springer.com/drugs/800026963
Fish, P. V., et al. "Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. "Journal of Medicinal Chemistry 50.10(2007):2341.

UK-371804 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from UK-371804 manufacturers

Career Henan Chemical Co

Product: UK-371804 256477-09-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-20

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C14H16ClN5O4S