Mal-amido-PEG8-TFP ester
- Product Name
- Mal-amido-PEG8-TFP ester
- CAS No.
- 1924596-31-5
- Chemical Name
- Mal-amido-PEG8-TFP ester
- Synonyms
- Mal-NH-PEG8-TFP;Mal-dPEG8-PFP ester;Mal-amido-PEG8-TFP ester;2,3,5,6-Tetrafluorophenyl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oate;4,7,10,13,16,19,22,25-Octaoxa-28-azahentriacontanoic acid, 31-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-29-oxo-, 2,3,5,6-tetrafluorophenyl ester
- CBNumber
- CB13162982
- Molecular Formula
- C32H44F4N2O13
- Formula Weight
- 740.69
- MOL File
- 1924596-31-5.mol
Mal-amido-PEG8-TFP ester Property
- Boiling point:
- 780.6±60.0 °C(Predicted)
- Density
- 1.292±0.06 g/cm3(Predicted)
- pka
- 15.01±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 10552
- Product name
- MAL-dPEG®₈-TFPester
- Packaging
- 100mg
- Price
- $225
- Updated
- 2021/12/16
- Product number
- BP-22741
- Product name
- Mal-amido-PEG8-TFPester
- Purity
- 95%
- Packaging
- 500mg
- Price
- $480
- Updated
- 2021/12/16
Mal-amido-PEG8-TFP ester Chemical Properties,Usage,Production
Description
Mal-amido-PEG8-TFP ester is PEG linker containing a maleimide and TFP ester end group. Maleimide groups are reactive with thiols between pH 6.5 and 7.5. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. The hydrophilic PEG chains increase the water solubility of a compound in aqueous media. Longer PEG chains have improved water solubility relative to shorter PEG chains.
Uses
Mal-amido-PEG8-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Mal-amido-PEG8-TFP ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Mal-amido-PEG8-TFP ester manufacturers
- Product
- Mal-amido-PEG8-TFP ester 1924596-31-5
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-27