NORTRIPTYLINE
- Product Name
- NORTRIPTYLINE
- CAS No.
- 72-69-5
- Chemical Name
- NORTRIPTYLINE
- Synonyms
- Aventyl;nortryptyline;Ateben;C07274;Avantyl;lambeck;Lumbeck;Sesaval;allegron;Noritren
- CBNumber
- CB1317147
- Molecular Formula
- C19H21N
- Formula Weight
- 263.38
- MOL File
- 72-69-5.mol
NORTRIPTYLINE Property
- Melting point:
- 58 °C
- Boiling point:
- 396.62°C (rough estimate)
- Density
- 0.9790 (rough estimate)
- refractive index
- 1.4900 (estimate)
- storage temp.
- 4°C, protect from light
- pka
- pKa 9.7 (Uncertain)
- BCS Class
- 1
- EPA Substance Registry System
- Nortriptyline (72-69-5)
Safety
- Hazardous Substances Data
- 72-69-5(Hazardous Substances Data)
- Toxicity
- LD50 orl-rat: 502 mg/kg HEPHD2 55,527,80
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- N4005-02
- Product name
- Nortriptyline
- Packaging
- 500ul
- Price
- $393
- Updated
- 2021/12/16
- Product number
- API0003635
- Product name
- NORTRIPTYLINE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $742
- Updated
- 2021/12/16
- Product number
- API0003635
- Product name
- NORTRIPTYLINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $756
- Updated
- 2021/12/16
NORTRIPTYLINE Chemical Properties,Usage,Production
Originator
Aventyl,Lilly,UK,1963
Uses
Nortriptyline is a drug with a relatively short latent period of action. It is practically devoid of sedative effects. It is used in manic-depressive psychoses, in all forms of endogenous depression, and also in major depressive conditions.
Uses
Antidepressant.
Definition
ChEBI: An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Manufacturing Process
A mixture of 114.5 g of 5-(3-chloropropylidene)dibenzo[a,d]cyclohepta[1,4] diene, 75 ml of benzene, and about 400 ml of methylamine is heated in an autoclave at 120°C for six hours. The excess methylamine is distilled from the reaction mixture under vacuum and the residue is stirred with 300 ml of water. Acidification of the mixture with hydrochloric acid causes the separation of the hydrochloride of 5-(3-methylaminopropylidene)dibenzo[a,d] cyclohepta[1,4]diene. The product is collected by filtration and is purified by recrystallization from a mixture of absolute ethanol and ethyl acetate. MP 210°C to 212°C.
brand name
Aventyl Hydrochloride (Lilly); Aventyl Hydrochloride (Ranbaxy); Pamelor (Tyco).
Therapeutic Function
Antidepressant
Clinical Use
Tricyclic antidepressant
Safety Profile
Poison by ingestion,intraperitoneal, and intravenous routes. When heated todecomposition it emits toxic fumes of NOx.
Synthesis
Nortriptyline is 5-(3-methylaminopropyliden)-10,11-dihydrodibenzcycloheptene (7.1.17). Nortriptyline differs from desipramine in the same manner in which amitriptyline differs from imipramine. In nortriptyline, the nitrogen atom in the central part of the tricyclic system of desipramine is replaced by a carbon atom, which is bound to a side chain by a double bond.
Two suggested methods of nortriptyline synthesis are based on the N-demethylation of amitriptyline. The third way utilizes the reaction of methylamine with 5-(3-bromopropyliden)-10,11-dihydro-5H-dibenz[a,d]cycloheptene (7.1.18).
According to the first scheme, demethylation takes place by the reaction of amitriptyline (7.1.4) with methyliodide, which leads to the formation of a quaternary ammonium salt (7.1.16), the reaction of which with methylamine at a relatively high temperature gives the desired nortriptyline (7.1.17) [25].
According to the third scheme, nortriptyline is synthesized by reacting methylamine with 5-(3-bromopropyliden)-10,11-dihydro-5H-dibenz[a,d]cycloheptene (7.1.6) [8].
Drug interactions
Potentially hazardous interactions with other drugs
Alcohol: increased sedative effect.
Analgesics: increased risk of CNS toxicity with
tramadol; possibly increased risk of side effects with
nefopam; possibly increased sedative effects with opioids.
Anti-arrhythmics: increased risk of ventricular
arrhythmias with amiodarone - avoid; increased
risk of ventricular arrhythmias with disopyramide,
flecainide or propafenone; avoid with dronedarone.
Antibacterials: increased risk of ventricular
arrhythmias with delamanid, moxifloxacin and
possibly telithromycin - avoid with moxifloxacin.
Anticoagulants: may alter anticoagulant effect of
coumarins.
Antidepressants: enhanced CNS excitation and
hypertension with MAOIs and moclobemide -
avoid; concentration possibly increased with SSRIs;
risk of ventricular arrhythmias with citalopram and
escitalopram - avoid; increased risk of convulsions
with vortioxetine.
Antiepileptics: convulsive threshold lowered;
concentration reduced by carbamazepine,
fosphenytoin, phenobarbital and possibly phenytoin.
Antimalarials: avoid with artemether/lumefantrine
and piperaquine with artenimol.
Antipsychotics: increased risk of ventricular
arrhythmias especially with droperidol, haloperidol,
pimozide, risperidone and sulpiride - avoid;
increased antimuscarinic effects with clozapine
and phenothiazines; concentration increased by
antipsychotics.
Antivirals: increased risk of ventricular arrhythmias
with saquinavir - avoid; concentration possibly
increased with ritonavir.
Atomoxetine: increased risk of ventricular
arrhythmias and possibly convulsions.
Beta-blockers: increased risk of ventricular
arrhythmias with sotalol.
Clonidine: tricyclics antagonise hypotensive effect;
increased risk of hypertension on clonidine withdrawal.
Dapoxetine: possible increased risk of serotonergic
effects - avoid.
Dopaminergics: avoid use with entacapone; CNS
toxicity reported with selegiline and rasagiline.
Pentamidine: increased risk of ventricular
arrhythmias.
Sympathomimetics: increased risk of hypertension
and arrhythmias with adrenaline and noradrenaline;
metabolism possibly inhibited by methylphenidate.
Metabolism
Nortriptyline is a secondary amine dibenzocycloheptene TCA as well as the major metabolite of amitriptyline. Similar to desipramine, nortriptyline appears in mother's milk and is metabolized by CYP2D6 to the primary amine and by ring hydroxylation to its E-10-hydroxy metabolite. Approximately one-third of a dose of nortriptyline is excreted in urine as metabolites within 24 hours, and small amounts are excreted in feces via biliary elimination.
NORTRIPTYLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from NORTRIPTYLINE manufacturers
- Product
- nortriptyline 72-69-5
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-09-05
- Product
- NORTRIPTYLINE 72-69-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-26